MIA_01873_1

Protein

Length

577 amino acids

Browser: contig02:1942961-1944695+

Protein function

EGGNOG:	0QDYB		Major Facilitator Superfamily
SGD closest match:	S000005799	TPO4	Polyamine transporter 4
CGD closest match:	CAL0000176089	TPO4	Tpo4p

Protein alignments

	%id	Aln length	E-value
MCA_01290_1	69.72%	535	0.0	MCA_01290_1
A0A0J9XCJ3_GEOCN	64.77%	491	0.0	Similar to Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein, recognizes spermine,putrescine, and spermidine OS=Geotrichum candidum GN=BN980_GECA08s01110g PE=4 SV=1
A0A1E3PJD3_9ASCO	60.73%	466	0.0	Polyamine transport protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_24585 PE=4 SV=1
UniRef50_A3M0B3	56.69%	478	2e-177	Polyamine transport protein (TPO4) (Fragment) n=3 Tax=Debaryomycetaceae TaxID=766764 RepID=A3M0B3_PICST
TPO4_YEAST	55.47%	503	1e-169	Polyamine transporter 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO4 PE=1 SV=1
A0A1D8PSL9_CANAL	51.67%	478	4e-159	Tpo4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TPO4 PE=4 SV=1
A0A1E4TIJ4_9ASCO	47.60%	479	9e-138	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46606 PE=4 SV=1
A0A060T6E5_BLAAD	34.39%	503	2e-82	ARAD1B15224p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15224g PE=4 SV=1
A0A167FTU2_9ASCO	36.80%	462	6e-82	Tpo2p OS=Sugiyamaella lignohabitans GN=TPO2 PE=4 SV=1
Q6CDU4_YARLI	35.81%	497	9e-76	YALI0B21142p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21142g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0166

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
77 - 532
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 577

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  102 - 489
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  94 - 529
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  77 - 532
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  98 - 522
  
  CDD
  cd06174 (MFS)
IPR005829

Sugar transporter, conserved site
1. PS00216 (SUGAR_TRAN...)
  
  148 - 164
  
  PROSITE patterns
  PS00216 (SUGAR_TRANSPORT_1)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

344 - 354

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

208 - 218

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 91

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

148 - 158

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

429 - 439

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

492 - 502

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

269 - 288

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

306 - 562

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

77 - 288

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

180 - 184

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

378 - 408

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

308 - 318

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

114 - 124

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

463 - 467

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

243 - 247

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

523 - 577

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

92 - 114

TMHMM
TMhelix (TMhelix)

441 - 463

TMHMM
TMhelix (TMhelix)

127 - 149

TMHMM
TMhelix (TMhelix)

468 - 490

TMHMM
TMhelix (TMhelix)

291 - 310

TMHMM
TMhelix (TMhelix)

503 - 525

TMHMM
TMhelix (TMhelix)

221 - 243

TMHMM
TMhelix (TMhelix)

184 - 206

TMHMM
TMhelix (TMhelix)

250 - 267

TMHMM
TMhelix (TMhelix)

323 - 345

TMHMM
TMhelix (TMhelix)

355 - 377

TMHMM
TMhelix (TMhelix)

159 - 177

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

355 - 377

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

503 - 522

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

219 - 242

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

159 - 179

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

440 - 462

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

319 - 343

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

125 - 147

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

468 - 491

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

409 - 428

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

248 - 268

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

289 - 307

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

92 - 113

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

185 - 207

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 82

MobiDB Lite
mobidb-lite (disorder_prediction)

544 - 577

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

109S

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

112F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

113V

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

114S

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

116T

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

117F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

134L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

137Y

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

138L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

141L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

145P

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

146V

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

148G

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

149A

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

195A

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

196S

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

199M

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

200A

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

203G

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

204G

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

207S

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

219M

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

220T

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

223C

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

224F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

230P

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

331F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

334L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

335F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

338F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

339E

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

342P

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

356T

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

360F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

364G

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

367L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

371V

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

447G

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

450L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

451L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

454F

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

458L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

459L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

462M

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

473A

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

474L

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

477N

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

478N

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

481R

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

482Y

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

485A

putative substrate translocation pore
109S, 112F, 113V, 114S, 116T, 117F, 134L, 137Y, 138L, 141L, 145P, 146V, 148G, 149A, 195A, 196S, 199M, 200A, 203G, 204G, 207S, 219M, 220T, 223C, 224F, 230P, 331F, 334L, 335F, 338F, 339E, 342P, 356T, 360F, 364G, 367L, 371V, 447G, 450L, 451L, 454F, 458L, 459L, 462M, 473A, 474L, 477N, 478N, 481R, 482Y, 485A
CDD
cd06174 (MFS)

Protein sequence

>MIA_01873_1
MSSSGALTPETYGEKPANEDKISDSSSDNSNDIYSPDNDEIPLPLTEKPNAHRPLHRTPQPDSDEPVPLESLDWDSPDDP
ENPQNWSDFKKWVITMTAAFMCLSVTCGSSLFVSGTFDMMAKFHASQTLVLSGLTFYLIGLSLGPVLGAPLSEIFGRKIV
YLTSMPISMLFVMGVGLSTNIWSVLILRFFSGFFASPVMAIAGGTISDLWSIEMLGVTMTAFCFAPFAGPVLGPIMGGFA
VAAKGWKWTMWISLMLSGVTIPFILWMPETYKRTIMRRRAKKRGITLQKPQMGLGGFLKLILVLTVLRPLQMLFAREPIV
IVLSIYSAFVFAILFGFFEAYPVIYTGVYGMSHSITGLTFIGIGVGLCFGVVVFLSIDRFVFYPRQPDGTRIPKDENGNP
VIPTAESRLLPAKIGAILLPVSLFWQAWTARTNVHWMAPLAAGVPFGMSLLLIFFSVLLYFMLSYPTIILASALAANNLA
RYIIASVFPLFTVQMYKRMHISWASSFFAFVALAMMPIPWLFEIYGPKLRARSYFNRLIAEEERKRKEREEAGEPEDEED
NISLALARTMSRSESMV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features