MCA_01290_1

Protein

Length

571 amino acids

RNA-seq: read pairs 35781, FPKM 772.9, percentile rank 95.9% (100% = highest expression)

Protein function

EGGNOG:	0QDYB		Major Facilitator Superfamily
SGD closest match:	S000005799	TPO4	Polyamine transporter 4
CGD closest match:	CAL0000176089	TPO4	Tpo4p

Protein alignments

	%id	Aln length	E-value
MIA_01873_1	66.15%	576	0.0	MIA_01873_1
A0A0J9XCJ3_GEOCN	64.03%	531	0.0	Similar to Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein, recognizes spermine,putrescine, and spermidine OS=Geotrichum candidum GN=BN980_GECA08s01110g PE=4 SV=1
A0A1E3PJD3_9ASCO	62.37%	465	0.0	Polyamine transport protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_24585 PE=4 SV=1
UniRef50_A3M0B3	56.07%	478	2e-171	Polyamine transport protein (TPO4) (Fragment) n=3 Tax=Debaryomycetaceae TaxID=766764 RepID=A3M0B3_PICST
TPO4_YEAST	50.54%	560	2e-163	Polyamine transporter 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO4 PE=1 SV=1
A0A1D8PSL9_CANAL	50.00%	510	4e-156	Tpo4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TPO4 PE=4 SV=1
A0A1E4TIJ4_9ASCO	48.36%	488	3e-136	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46606 PE=4 SV=1
A0A167FTU2_9ASCO	35.56%	464	5e-75	Tpo2p OS=Sugiyamaella lignohabitans GN=TPO2 PE=4 SV=1
A0A060T6E5_BLAAD	33.20%	518	1e-70	ARAD1B15224p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15224g PE=4 SV=1
Q6CDU4_YARLI	32.17%	544	2e-69	YALI0B21142p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21142g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0855

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
73 - 525
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 571

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  97 - 484
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  90 - 525
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  73 - 525
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  93 - 517
  
  CDD
  cd06174 (MFS)
IPR005829

Sugar transporter, conserved site
1. PS00216 (SUGAR_TRAN...)
  
  144 - 160
  
  PROSITE patterns
  PS00216 (SUGAR_TRANSPORT_1)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

207 - 217

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

457 - 462

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

518 - 571

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

268 - 287

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

144 - 154

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

341 - 351

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 87

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

534 - 554

COILS
Coil (Coil)
G3DSA:1.20.12...

69 - 288

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

303 - 568

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

487 - 497

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

110 - 120

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

241 - 245

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

174 - 184

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

307 - 317

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

373 - 428

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

458 - 480

TMHMM
TMhelix (TMhelix)

88 - 110

TMHMM
TMhelix (TMhelix)

123 - 145

TMHMM
TMhelix (TMhelix)

247 - 264

TMHMM
TMhelix (TMhelix)

404 - 421

TMHMM
TMhelix (TMhelix)

495 - 517

TMHMM
TMhelix (TMhelix)

431 - 453

TMHMM
TMhelix (TMhelix)

155 - 174

TMHMM
TMhelix (TMhelix)

289 - 311

TMHMM
TMhelix (TMhelix)

350 - 372

TMHMM
TMhelix (TMhelix)

318 - 340

TMHMM
TMhelix (TMhelix)

213 - 235

TMHMM
TMhelix (TMhelix)

181 - 203

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

218 - 240

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

88 - 109

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

429 - 456

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

352 - 372

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

463 - 486

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

318 - 340

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

121 - 143

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

498 - 517

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

155 - 173

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

246 - 267

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

185 - 206

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

288 - 306

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 76

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

105S

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

108F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

109V

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

110S

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

112T

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

113F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

130L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

133Y

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

134L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

137L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

141P

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

142I

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

144G

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

145A

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

191A

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

192S

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

195M

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

196A

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

199G

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

200G

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

203S

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

215M

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

216S

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

219C

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

220L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

226P

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

326F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

329L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

330F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

333F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

334E

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

337P

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

351Q

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

355F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

359G

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

362L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

366T

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

442G

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

445L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

446L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

449F

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

453L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

454L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

457S

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

468A

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

469L

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

472N

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

473N

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

476R

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

477Y

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

480A

putative substrate translocation pore
105S, 108F, 109V, 110S, 112T, 113F, 130L, 133Y, 134L, 137L, 141P, 142I, 144G, 145A, 191A, 192S, 195M, 196A, 199G, 200G, 203S, 215M, 216S, 219C, 220L, 226P, 326F, 329L, 330F, 333F, 334E, 337P, 351Q, 355F, 359G, 362L, 366T, 442G, 445L, 446L, 449F, 453L, 454L, 457S, 468A, 469L, 472N, 473N, 476R, 477Y, 480A
CDD
cd06174 (MFS)

Protein sequence

>MCA_01290_1
MTDTETSSPVSKNSGSYNPSTLGTDDNSSTHSNEIFVPEKLERDEEPAQEKRQRRKPGPDDEIPLEDMDWDGPDDMENPK
NWSNLKKWAITMVVAAMTLVVTLGSSLFVSGTFDIMAKMHASQTLVLSGLTFYLVGLSLGPILGAPLSELFGRRIVYITT
LPLSMLFIMGVGLSKNIGSILVLRFFAGFFASPVMAIAGGTVSDLWDIDMVGLAMSAFCLAPFAGPILGPIIGGFAVQAY
EWKWTMWVNLMFCGAVLPFVALTPETYKRALMRKRAKQRNIKIAKPKMSLGQFLKLIFVLTIARPLKMLVVEPITIVFSI
YTAFVFAILFGFFEAYPVIFTGVYHFTHAIQGLTFIGIGVGLLIGTVVYIWIDRRIYFPLQPDGTRMPKDENGNIIYPQA
ESRLLPAKIGAVLLPISLFWQAWCARSSVHWMAVVAAGAPFGMSLLLIFYTVLLYFSLAYPTIILASALAANNLLRYIVA
SVFPLFTVQMYEKLGIDWASSLFGFIAIALMPVPWIFERIGPKLRAKSHYNRLIAEEERRRKEHLATSDEEEEEDLELAI
ARTMSRTQSRV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features