Protein

MIA_01783_1

Length
581 amino acids

Browser: contig02:1674603-1676349-

Protein function

EGGNOG:0PGY0HRD1Ring finger protein
SGD closest match:S000005373HRD1ERAD-associated E3 ubiquitin-protein ligase HRD1
CGD closest match:CAL0000177443CAALFM_CR06470WAE3 ubiquitin-protein ligase

Protein alignments

%idAln lengthE-value
MCA_02849_161.516%3432.49e-148MCA_02849_1
A0A0J9X2M5_GEOCN48.949%3332.35e-88Similar to Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins OS=Geotrichum candidum GN=BN980_GECA01s03970g PE=4 SV=1
UniRef50_A0A0J9X2M548.949%3334.80e-85Similar to Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2M5_GEOCN
A0A060T830_BLAAD41.593%3398.70e-81ARAD1C33088p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C33088g PE=4 SV=1
A0A1E3PD02_9ASCO39.818%3291.50e-67Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84469 PE=4 SV=1
A0A167DUK4_9ASCO45.051%2932.22e-63E3 ubiquitin-protein ligase HRD1 OS=Sugiyamaella lignohabitans GN=HRD1 PE=4 SV=1
A0A1E4TIG7_9ASCO36.467%3511.29e-53Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_42196 PE=4 SV=1
Q6C334_YARLI31.563%3395.02e-47YALI0F02981p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02981g PE=4 SV=1
A0A1D8PT95_CANAL36.420%1624.97e-22E3 ubiquitin-protein ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06470WA PE=4 SV=1
HRD1_YEAST42.857%842.66e-16ERAD-associated E3 ubiquitin-protein ligase HRD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRD1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3533

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 581

Detailed signature matches

  1. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  2. Domain IPR001841
    Zinc finger, RING-type
    1. SM00184 (ring_2)
    2. PF13639 (zf-RING_2)
    3. PS50089 (ZF_RING_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SSF57850 (RING/U-box)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. cd16479 (RING-H2_sy...)
  7. mobidb-lite (disord...)

Residue annotation

  1. Zn binding site cd...

Protein sequence

>MIA_01783_1
MHFFLYIIASIVLAILVVGLPLLSRPNFFSASVMIYQNSLSMLILGNLGVVFALILGKALQLLFFGPLYTLETERIYESA
WYAVTESLLLVPLLKDDSKIEIGIFFATLLFLRVFHWISSGRIETIFQTQSSYFSHFRLCSAIAFLGLADIYLIRYWVMT
FQYSSNSDRNSVTVPTFAFECLLLLNSILTTTGKYILNLVEAYYLKNHEDEDIWESKTYWSFILEVISLFTRLSAYCVLF
FLILLPYRLLPLHIIRDTYVTAKSLISTIQKHIKGRRAKRQIENVVHTVTQEELSNADDVCIICREDMVLEEGQHPRTIP
KKLLCGHILHFGCLKGWLERSLRCPTCRRSVMDGTFPDQPGAANNNAANGNNAMNQNNGLNLNANLRGQNNQIPGLNNAP
NVQNINQMPPTPTIPLNQHNLPPNFPFLQNPENLSFLSTQVFNFPHQAEMPEGFQMPLGWNVLAARETPDGELQIQVTSD
YWATVMPSNLPQESKNNENASTHEPPVDLGEKSAPNTTEIGISSTGSVSENPSKKGKEKPSFGHETQNDSEDEKSTAVAV
DTTGSSSALKPEISSVETSES

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.