Protein

MCA_02849_1

Length
611 amino acids

Gene name: HRD1

Description: ERAD-associated E3 ubiquitin-protein ligase HRD1

Browser: contigB:2507122-2508958+

RNA-seq: read pairs 2092, FPKM 42.2, percentile rank 61.6% (100% = highest expression)

Protein function

Annotation:HRD1ERAD-associated E3 ubiquitin-protein ligase HRD1
KEGG:K10601SYVN1 E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
EGGNOG:0PGY0HRD1Ring finger protein
SGD closest match:S000005373HRD1ERAD-associated E3 ubiquitin-protein ligase HRD1
CGD closest match:CAL0000177443CAALFM_CR06470WAE3 ubiquitin-protein ligase

Protein alignments

%idAln lengthE-value
MIA_01783_160.34%3582e-155MIA_01783_1
A0A0J9X2M5_GEOCN48.31%3543e-96Similar to Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins OS=Geotrichum candidum GN=BN980_GECA01s03970g PE=4 SV=1
UniRef50_A0A0J9X2M548.31%3546e-93Similar to Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2M5_GEOCN
A0A060T830_BLAAD43.63%3535e-94ARAD1C33088p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C33088g PE=4 SV=1
A0A1E3PD02_9ASCO38.20%3564e-74Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84469 PE=4 SV=1
A0A167DUK4_9ASCO47.62%2944e-73E3 ubiquitin-protein ligase HRD1 OS=Sugiyamaella lignohabitans GN=HRD1 PE=4 SV=1
A0A1E4TIG7_9ASCO34.13%3752e-55Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_42196 PE=4 SV=1
Q6C334_YARLI29.81%3593e-46YALI0F02981p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02981g PE=4 SV=1
A0A1D8PT95_CANAL34.57%1622e-19E3 ubiquitin-protein ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06470WA PE=4 SV=1
HRD1_YEAST31.30%1159e-14ERAD-associated E3 ubiquitin-protein ligase HRD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRD1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2762
Predicted cleavage: 12

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 611

Detailed signature matches

  1. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  2. Domain IPR001841
    Zinc finger, RING-type
    1. SM00184 (ring_2)
    2. PF13639 (zf-RING_2)
    3. PS50089 (ZF_RING_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SSF57850 (RING/U-box)
  9. SignalP-TM
  10. TMhelix
  11. TRANSMEMBRANE (Tran...)
  12. cd16479 (RING-H2_sy...)
  13. mobidb-lite (disord...)

Residue annotation

  1. Zn binding site cd...

Protein sequence

>MCA_02849_1
MRFLVYSAVSTVLTAFVIASPLVNSPNFYSAAIEVYNNSVFMIILGNMCLIMLFVIGKILQMMFFGHLHTLERDRLYESA
WYTLTESVLLVPLLRDDSKLQFLAFFGILLFIRIFHWICADRVDIIFQTVAPPSYINHARLATAIILLGLTDLYLIRYWV
MSFQYSSDSDTNSVMVPTFSFECLLLFNSIFNTAGKYLLNVIESIYLHNHEDEDIWDKKTLYTFYLELVTKLSRLLAYLA
LFFFILLPYKLIPLHIFRDCYVTFVSLASLVQTHIRAQNAKRQIETVVRNITREELQEIDDVCIICREEMTVEDDQPART
VPKRLICGHTIHFGCLTSWLERSLRCPTCRRSVMDGSFPNTPNATPPAPQQNRNPPAAPDHQAQNNEAANHTPTRAVNAD
DGTQSNLTSTAAASTSSNSNNSTNDIINSHIVEPNGTANSSSSSSAQSQSSSVIQNGNHIYSNISHSSQNAAPSSTASNY
RPFALKNHVELPAGFQIPRQWGTFEARKTIDGRLQVHISENIWVDIMVPSDEQKFSAVPNDKKSKESTKELTTESSGTTS
NITPVTRAGPFSAEPIVPKADEESSQNNIATEAHEEELNTSSTERVEDASE

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.