Protein

MIA_01763_1

Length
597 amino acids

Browser: contig02:1612795-1614589+

Protein function

EGGNOG:0PGD0TRM2trna (uracil-5-)-methyltransferase
SGD closest match:S000001764TRM2tRNA (uracil(54)-C(5))-methyltransferase
CGD closest match:CAL0000192336TRM2Trm2p

Protein alignments

%idAln lengthE-value
MCA_04601_168.14%4990.0MCA_04601_1
A0A0J9X8C1_GEOCN61.52%4990.0Similar to Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase OS=Geotrichum candidum GN=BN980_GECA05s01748g PE=3 SV=1
A0A060TCV7_BLAAD59.76%4920.0ARAD1D38940p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38940g PE=3 SV=1
A0A161HLU2_9ASCO58.05%5030.0Trm2p OS=Sugiyamaella lignohabitans GN=TRM2 PE=3 SV=1
UniRef50_A0A161HLU258.05%5030.0Trm2p n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A161HLU2_9ASCO
TRM2_YEAST46.27%5234e-146tRNA (uracil(54)-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRM2 PE=1 SV=2
A0A1D8PCG3_CANAL46.82%5192e-144Trm2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TRM2 PE=3 SV=1
Q6C110_YARLI44.99%5097e-141YALI0F20196p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20196g PE=3 SV=1
A0A1E3PND4_9ASCO53.40%4129e-142S-adenosyl-L-methionine-dependent methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82207 PE=3 SV=1
A0A1E4TAD2_9ASCO42.29%5062e-120Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32229 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7283

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 597

Detailed signature matches

  1. Family IPR010280
    (Uracil-5)-methyltransferase family
    1. PF05958 (tRNA_U5-me...)
    2. PS51687 (SAM_MT_RNA...)
  2. Family IPR025795
    tRNA (uracil-5-)-methyltransferase
    1. PS51622 (SAM_MT_RNA...)
  3. Domain IPR002792
    TRAM domain
    1. PF01938 (TRAM)
    2. PS50926 (TRAM)
  4. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
  5. SITE IPR030390
    RNA methyltransferase TrmA, active site
    1. PS01230 (TRMA_1)
  6. SITE IPR030391
    RNA methyltransferase TrmA, conserved site
    1. PS01231 (TRMA_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.40.50...
  3. cd02440 (AdoMet_MTases)
  4. mobidb-lite (disord...)

Residue annotation

  1. S-adenosylmethioni...

Protein sequence

>MIA_01763_1
MKKISFRLTSSLIAHKLQINPSVYQPKRFGLSSSFNLIKVYSSLPTMAVDNSTINTITSVEQSSTNSSLTLDSSINKNKR
NRDQENTLKKGKPKGKKFKEPPLADPISHEGVLITDIKSFLKSKNVAVEDVANDLKEFFSRPKGTSHPEHRSVLVKIEAL
SSIGEGLGLVEIPIDDSTSQETTLKPKYQVVVVPFTVVGDEVEAKIYKTQKFYFNADLIKVTVSSPKRNESLVNCKYFGK
CSGCQYQMIEYKDQLEIKRNVIVNAYKHNSNLDPIHIPEIDETVGSPLKYNYRTKLTPHFDIPRKTPDTAPPVGFGQPGR
KAILDIEECSIGTSVINGGLKKQRSWFQENFRQYKRGATFLLRENTVPKTDTERDDDSKNDTQEKDMNIVEKEKICSTST
KDIITEYVGDYVFTYPASSFFQNNNSILTTVTNYVRENIKLPQTGQPPTFLVDTYCGCGLFAITCCGKAEKVIGVEISQD
SVQYARKNAKLNNVNAEFIVGQAEKIFNGVTTNPNETSIIIDPPRKGCDVQFLDQLLAFRPAKIVYVSCNVHSQARDIGY
ILNSEKGKVYQIESIRGFDFFPQTYHVESVAVLSLKY

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0008033 tRNA processing

Molecular Function

GO:0008173 RNA methyltransferase activity
GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity

Cellular Component

None predicted.