Protein
MIA_01757_1
Length
643 amino acids
Browser: contig02:1595953-1597885-
Protein function
| EGGNOG: | 0PGFF | FG10188.1 | Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro) (By similarity) |
|---|---|---|---|
| SGD closest match: | S000004990 | LAP2 | Leukotriene A-4 hydrolase homolog |
| CGD closest match: | CAL0000197502 | LKH1 | Leukotriene A-4 hydrolase homolog |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_02954_1 | 74.806% | 643 | 0.0 | MCA_02954_1 |
| A0A0J9XKH8_GEOCN | 64.760% | 647 | 0.0 | Leukotriene A(4) hydrolase OS=Geotrichum candidum GN=BN980_GECA27s00450g PE=3 SV=1 |
| A0A167FB00_9ASCO | 60.337% | 653 | 0.0 | Leukotriene A(4) hydrolase OS=Sugiyamaella lignohabitans GN=LAP2 PE=3 SV=1 |
| A0A060T0L8_BLAAD | 58.713% | 637 | 0.0 | Leukotriene A(4) hydrolase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C09240g PE=3 SV=1 |
| A0A1E3PRF2_9ASCO | 57.053% | 638 | 0.0 | Leukotriene A(4) hydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44684 PE=3 SV=1 |
| LKHA4_YARLI | 55.818% | 636 | 0.0 | Leukotriene A-4 hydrolase homolog OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F00396g PE=3 SV=1 |
| LKHA4_YEAST | 52.705% | 647 | 0.0 | Leukotriene A-4 hydrolase homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAP2 PE=1 SV=1 |
| UniRef50_Q6CLD3 | 51.464% | 649 | 0.0 | Leukotriene A-4 hydrolase homolog n=74 Tax=Saccharomycetales TaxID=4892 RepID=LKHA4_KLULA |
| LKHA4_CANAL | 47.005% | 651 | 0.0 | Leukotriene A-4 hydrolase homolog OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LKH1 PE=3 SV=2 |
| A0A1E4TL55_9ASCO | 23.690% | 477 | 5.94e-20 | Aminopeptidase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30620 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2888
Protein family membership
- Leukotriene A4 hydrolase-like (IPR034015)
- Leukotriene A4 hydrolase (IPR012777)
Domains and repeats
-
Domain
1
100
200
300
400
500
643
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
active site cd09599
-
Zn binding site cd...
Protein sequence
>MIA_01757_1 MSTTIFDIKRPAQSPERDPSTLSNYYAFKVNFTEIEYRVNWDKKVLAGKVTYNLVVKEPSQTSNIILDTSYLDVFKASID DDETPFVLAEKRIEPLGTKLTIPLNDWKTKTSGAKSQLKLSLEFSTTEKVTAVQWLEPEQTAGKTAPYLFSQCEAIHARS MYPCFDTPSVKSPMNISIYSIYPTVSSGNVVSKPSEPGSEDKPYVFKQDLPIPSYLFAIASGDIANAPIGPRSLIYSEPS FIKACQYEFKADTENFIEVAEKLVFPYEWKTYNVLILPPSFPYGGMENPNITFATPTLISGDRQNVDVIAHELAHSWSGN LVTNCSWEHFWLNEGWTMYLERRIVGSIHGEAYRHFSAIIGWKDLQDDIDSMSPATREKYSPLVVDLSNQADPDDAFSTV PYEKGFNLLFLIEQKLGGFKEFDPFIPFYFTKFRTQSLDTYQFKDTLYDFFKDKKEILDEIDWDTWFYSPGMPPVKPDFD TSLADACYSLSTKWVDAALSAPKDATVSYFKEKFSIKNLEGWNSQQYLVFLDSVTDSPKIKWSDPAPSNAVKALGEIYEF ESSSNPEVISRWFKIAVKACLGYESTYYPLADWLGTVGRMKFVRPGYRELAKVDKSLAISTFTKNELFYHPICRNMVARD LGL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0004463 leukotriene-A4 hydrolase activity
GO:0005488 binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Cellular Component
None predicted.