Protein
MCA_02954_1
Length
709 amino acids
Gene name: LAP2
Description: Leukotriene A-4 hydrolase homolog; Leucyl aminopeptidase
Browser: contigB:2890548-2892678+
RNA-seq: read pairs 7185, FPKM 125.0, percentile rank 82.4% (100% = highest expression)
Protein function
| Annotation: | LAP2 | Leukotriene A-4 hydrolase homolog; Leucyl aminopeptidase | |
|---|---|---|---|
| KEGG: | K01254 | LTA4H | leukotriene-A4 hydrolase [EC:3.3.2.6] |
| EGGNOG: | 0PGFF | FG10188.1 | Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro) (By similarity) |
| SGD closest match: | S000004990 | LAP2 | Leukotriene A-4 hydrolase homolog |
| CGD closest match: | CAL0000197502 | LKH1 | Leukotriene A-4 hydrolase homolog |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01757_1 | 74.81% | 643 | 0.0 | MIA_01757_1 |
| A0A0J9XKH8_GEOCN | 65.94% | 643 | 0.0 | Leukotriene A(4) hydrolase OS=Geotrichum candidum GN=BN980_GECA27s00450g PE=3 SV=1 |
| A0A167FB00_9ASCO | 60.77% | 650 | 0.0 | Leukotriene A(4) hydrolase OS=Sugiyamaella lignohabitans GN=LAP2 PE=3 SV=1 |
| A0A060T0L8_BLAAD | 59.78% | 639 | 0.0 | Leukotriene A(4) hydrolase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C09240g PE=3 SV=1 |
| A0A1E3PRF2_9ASCO | 57.59% | 639 | 0.0 | Leukotriene A(4) hydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44684 PE=3 SV=1 |
| LKHA4_YEAST | 55.54% | 650 | 0.0 | Leukotriene A-4 hydrolase homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAP2 PE=1 SV=1 |
| LKHA4_YARLI | 55.89% | 637 | 0.0 | Leukotriene A-4 hydrolase homolog OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F00396g PE=3 SV=1 |
| UniRef50_Q6CLD3 | 53.56% | 646 | 0.0 | Leukotriene A-4 hydrolase homolog n=74 Tax=Saccharomycetales TaxID=4892 RepID=LKHA4_KLULA |
| LKHA4_CANAL | 47.36% | 663 | 0.0 | Leukotriene A-4 hydrolase homolog OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LKH1 PE=3 SV=2 |
| A0A1E4TFN6_9ASCO | 25.58% | 477 | 4e-21 | Aminopeptidase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57016 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9929
Predicted cleavage: 77
Protein family membership
- Leukotriene A4 hydrolase-like (IPR034015)
- Leukotriene A4 hydrolase (IPR012777)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
709
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
active site cd09599
-
Zn binding site cd...
Protein sequence
>MCA_02954_1 MSVLSSATRHSLVAWTTSVRGLCISAVKQAKLPTLSPYHHFLSSPSLSLQTHKHHYSQQSSMHAFTRKFDESRPAQSPQL DPSTLSNYQAFELKHTDIEYTVDWDKKKLVGSVKYKLTVKDVVTTHKIALDTSYLDVKSASIDGKTAPFALAKERIEPLG TLLQIPISLQPSSTSDNSKTITLELEFSTTEKVTAIQWLEPEQTDGKKAPYLFSQCEAIHARSLFPCFDTPSVKSPMKIS IYSKYPSVSSGVLAKSPKKDDDWKTTPYVFEQEIPIPSYLFAIASGDIASAPIGPRSHIYSEPSMLKACQYEFEADTEKF IEAAEKIVFPYEWKTYDVLILPPSFPYGGMENPNITFGTPTLISGDRQNVDVIAHELAHSWSGNLVTNCSWEHFWLNEGW TMYLERRIVGAIHGEAYRHFSAIIGWKDLQDSIDSMDTHTRDKYSRLVVDLQQGQDPDDAFSTVPYEKGFNLLFHIEQVL GGVEAFEPFIPYYFNKFKKQSLDTYQFKDTLFEFFKDRTKLLNQIDWDTWFFSPGMPPVKPKFDTSLVDNVYELSDKWVD SILNAPSDASKKYFEDKFSLNDLKDWNSQQYLVLLDSLTDSTKIEKWSEPVPSQAVKALGEIYKFSSSANPEVISRWYKI AVKARLGHESTYKPLADWLGTVGRMKFVRPGFRELNKVDKDLAVATFKKNEMFYHPICRSLVAKDLGLK
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0004463 leukotriene-A4 hydrolase activity
GO:0005488 binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Cellular Component
None predicted.