Protein

MIA_01730_1

Length
256 amino acids

Browser: contig02:1522670-1523441-

Protein function

EGGNOG:0PN8SUTR4Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
SGD closest match:S000000764UTR4Enolase-phosphatase E1
CGD closest match:CAL0000179480UTR4Enolase-phosphatase E1

Protein alignments

%idAln lengthE-value
A0A0J9X9N7_GEOCN51.923%2602.24e-86Similar to Saccharomyces cerevisiae YEL038W UTR4 Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases OS=Geotrichum candidum GN=BN980_GECA06s05125g PE=4 SV=1
MCA_00683_152.381%2732.21e-78MCA_00683_1
A0A167EJ17_9ASCO49.407%2539.24e-76Putative acireductone synthase UTR4 OS=Sugiyamaella lignohabitans GN=UTR4 PE=4 SV=1
A0A060T2Y0_BLAAD45.418%2515.32e-67Enolase-phosphatase E1 OS=Blastobotrys adeninivorans GN=UTR4 PE=3 SV=1
UniRef50_A0A060T2Y045.418%2511.31e-63Enolase-phosphatase E1 n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T2Y0_BLAAD
ENOPH_YARLI47.791%2491.53e-65Enolase-phosphatase E1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=UTR4 PE=3 SV=1
A0A1E3PRQ9_9ASCO41.406%2566.31e-552,3-diketo-5-methylthio-1-phosphopentane phosphatase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44759 PE=4 SV=1
A0A1E4TK37_9ASCO42.000%2502.35e-49Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_82247 PE=4 SV=1
ENOPH_CANAL40.586%2393.17e-48Enolase-phosphatase E1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UTR4 PE=3 SV=1
ENOPH_YEAST39.700%2671.78e-48Enolase-phosphatase E1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UTR4 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1772

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 256

Detailed signature matches

  1. Family IPR023943
    Enolase-phosphatase E1
    1. TIGR01691
  2. Domain IPR023214
    HAD-like domain
    1. SSF56784 (HAD-like)
    2. G3DSA:3.40.50...

Protein sequence

>MIA_01730_1
MATKKINSLLLDIEGTVCPISYVKEILFPYAKNAAAEKIPPLTQYFPLPDNVKDLDLGESTSTTVSSEDTELLGYLCAFP
QAARQSPVSLLGHIDGLIDNDVKDPALKALQGYLWHSGYVTGQVTAPIYPDAVKAIKKYSKELPSGVSIYSSGSVKAQIL
LFKHTTEDGDLTPYLSDYFDTINAGPKTVKESYDTISDALGVPNDTILFLSDNPKEVEAALSAGLNAYIVVRPGNAPLSE
EDKTKYKLVTTLDDII

GO term prediction

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine

Molecular Function

GO:0000287 magnesium ion binding
GO:0043874 acireductone synthase activity

Cellular Component

None predicted.