MIA_01712_1

Protein

Length

548 amino acids

Protein function

EGGNOG:	0PFTW	FG09697.1	transporter
SGD closest match:	S000006360	TPO3	Polyamine transporter 3
CGD closest match:	CAL0000197244	NAG4	Nag4p

Protein alignments

	%id	Aln length	E-value
MCA_01460_1	76.523%	558	0.0	MCA_01460_1
A0A0J9XGW4_GEOCN	71.082%	536	0.0	Similar to Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein specific for spermine OS=Geotrichum candidum GN=BN980_GECA16s02617g PE=4 SV=1
A0A060T6E5_BLAAD	64.060%	537	0.0	ARAD1B15224p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15224g PE=4 SV=1
A0A161HL76_9ASCO	66.409%	518	0.0	Tpo3p OS=Sugiyamaella lignohabitans GN=TPO3 PE=4 SV=1
A0A1E3PF73_9ASCO	62.731%	542	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84082 PE=4 SV=1
Q59RG0_CANAL	57.914%	556	0.0	Nag4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NAG4 PE=4 SV=1
UniRef50_Q59RG0	57.914%	556	0.0	Nag4p n=272 Tax=Fungi TaxID=4751 RepID=Q59RG0_CANAL
A0A1E4TLT0_9ASCO	55.941%	547	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1322 PE=4 SV=1
Q6CDU4_YARLI	39.219%	538	8.10e-101	YALI0B21142p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21142g PE=4 SV=1
TPO3_YEAST	36.347%	531	5.72e-95	Polyamine transporter 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0618

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
91 - 540
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 500 548

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  114 - 495
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  108 - 540
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  91 - 532
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  109 - 533
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

225 - 230

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

162 - 172

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

534 - 548

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

284 - 331

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

467 - 486

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 105

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

397 - 416

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

322 - 543

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

99 - 299

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

128 - 138

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

192 - 202

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

357 - 375

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

506 - 510

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

251 - 261

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

439 - 443

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

198 - 220

TMHMM
TMhelix (TMhelix)

444 - 466

TMHMM
TMhelix (TMhelix)

233 - 255

TMHMM
TMhelix (TMhelix)

332 - 354

TMHMM
TMhelix (TMhelix)

487 - 509

TMHMM
TMhelix (TMhelix)

260 - 282

TMHMM
TMhelix (TMhelix)

417 - 439

TMHMM
TMhelix (TMhelix)

172 - 194

TMHMM
TMhelix (TMhelix)

374 - 396

TMHMM
TMhelix (TMhelix)

143 - 165

TMHMM
TMhelix (TMhelix)

513 - 535

TMHMM
TMhelix (TMhelix)

106 - 128

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

444 - 466

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

376 - 396

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

417 - 438

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

139 - 161

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

173 - 191

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

262 - 283

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

231 - 250

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

332 - 356

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

511 - 533

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

203 - 224

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

106 - 127

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

487 - 505

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 33

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

123S

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

126I

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

127T

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

128G

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

130M

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

131E

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

148V

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

151F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

152V

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

155F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

159P

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

160L

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

162F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

163A

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

209F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

210S

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

213M

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

214T

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

217G

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

218G

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

221S

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

233M

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

234A

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

237S

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

238A

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

244P

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

349Y

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

352L

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

353Y

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

356F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

357F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

360P

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

374T

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

378F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

382A

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

385V

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

389S

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

457G

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

460F

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

461L

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

464Y

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

468N

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

469N

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

472V

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

482A

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

483L

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

486K

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

487T

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

490R

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

491S

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

494G

putative substrate translocation pore
123S, 126I, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 349Y, 352L, 353Y, 356F, 357F, 360P, 374T, 378F, 382A, 385V, 389S, 457G, 460F, 461L, 464Y, 468N, 469N, 472V, 482A, 483L, 486K, 487T, 490R, 491S, 494G
CDD
cd06174 (MFS)

Protein sequence

>MIA_01712_1
MSDLENSPRPYIKDDDLSSDEIHKTSTGRSLNEPRRITSAIDYAFEDPELSEAISRIQSRPDPKHLEVNDADPWKYLIDS
ETGYRLVEWLDNDPENPMNWSNGRKWFLTIALGIVCFTVAFASGVITGDMEGPAKRFSVSQEVVILTVTLFVVGFGIGPL
VFAPFSEEWGRQVIYNSTLLIAVIFIIPSAVAQNIGTLLVSRLISGIAFSAPMTLIGGSLSDIWKTEERGVAMAVFSAAP
FLGPVMGPLIGGYIGDHAGWRWIYWVMLIYSGVIYVFAVIFVPETHHVTLLRRRAKKLIKLTGDTKYKTKYDLAPVKLTS
MMKVALFRPFQLFVELIVFLISLYMSVIYALLYMFFFAYPVVFMEGKGWSAGKTGLTFIPIAVGVILSSLLAPWINKDYN
RRAKAYTDRGEVPPAELRLYPMMVGCWFVPIGLFIFAWTSYPRLIWVGPTLAGFPCGFGFLLLYNAANNYLVDSYQHYAA
SALAAKTCARSLAGAGVVLFTVQLMHMSYQWGVSIMAFISLACCAIPYLFFFYGAKIRARSKYAYDGY

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features