MCA_01460_1

Protein

Length

558 amino acids

RNA-seq: read pairs 126, FPKM 2.8, percentile rank 13.4% (100% = highest expression)

Protein function

EGGNOG:	0PFTW	FG09697.1	transporter
SGD closest match:	S000006360	TPO3	Polyamine transporter 3
CGD closest match:	CAL0000181510	NAG3	Nag3p

Protein alignments

	%id	Aln length	E-value
MIA_01712_1	76.52%	558	0.0	MIA_01712_1
A0A0J9XGW4_GEOCN	76.12%	536	0.0	Similar to Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein specific for spermine OS=Geotrichum candidum GN=BN980_GECA16s02617g PE=4 SV=1
A0A060T6E5_BLAAD	67.99%	528	0.0	ARAD1B15224p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15224g PE=4 SV=1
A0A161HL76_9ASCO	66.03%	527	0.0	Tpo3p OS=Sugiyamaella lignohabitans GN=TPO3 PE=4 SV=1
A0A1E3PF73_9ASCO	68.48%	495	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84082 PE=4 SV=1
UniRef50_A3LWM5	64.61%	503	0.0	Synaptic vesicle transporter SVOP n=102 Tax=Dikarya TaxID=451864 RepID=A3LWM5_PICST
A0A1D8PQG0_CANAL	65.81%	503	0.0	Nag3p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NAG3 PE=4 SV=1
A0A1E4TLT0_9ASCO	56.85%	533	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1322 PE=4 SV=1
Q6CDU4_YARLI	40.68%	526	2e-119	YALI0B21142p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21142g PE=4 SV=1
TPO3_YEAST	38.45%	528	9e-115	Polyamine transporter 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0146

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
91 - 550
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 558

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  114 - 507
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  108 - 550
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  91 - 542
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  112 - 536
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

544 - 558

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

219 - 229

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 105

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

477 - 496

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

167 - 172

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

292 - 340

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

406 - 425

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

96 - 308

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

331 - 554

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

448 - 452

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

126 - 144

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

252 - 270

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

516 - 520

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

194 - 198

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

366 - 384

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

198 - 220

TMHMM
TMhelix (TMhelix)

426 - 448

TMHMM
TMhelix (TMhelix)

341 - 363

TMHMM
TMhelix (TMhelix)

172 - 194

TMHMM
TMhelix (TMhelix)

143 - 165

TMHMM
TMhelix (TMhelix)

106 - 128

TMHMM
TMhelix (TMhelix)

383 - 405

TMHMM
TMhelix (TMhelix)

233 - 255

TMHMM
TMhelix (TMhelix)

454 - 476

TMHMM
TMhelix (TMhelix)

270 - 292

TMHMM
TMhelix (TMhelix)

489 - 511

TMHMM
TMhelix (TMhelix)

521 - 543

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

385 - 405

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

145 - 166

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

106 - 125

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

199 - 218

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

230 - 251

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

453 - 476

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

497 - 515

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

173 - 193

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

426 - 447

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

341 - 365

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

271 - 291

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

521 - 543

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 33

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

123S

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

126V

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

127T

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

128G

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

130M

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

131E

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

148V

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

151F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

152V

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

155F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

159P

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

160L

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

162F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

163A

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

209F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

210S

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

213M

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

214T

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

217G

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

218G

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

221S

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

233M

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

234A

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

237S

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

238A

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

244P

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

358Y

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

361L

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

362Y

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

365F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

366F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

369P

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

383T

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

387F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

391A

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

394V

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

398S

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

466G

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

469F

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

470L

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

473Y

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

477N

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

478N

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

481V

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

491A

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

492L

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

495K

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

496T

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

499R

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

500S

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

503G

putative substrate translocation pore
123S, 126V, 127T, 128G, 130M, 131E, 148V, 151F, 152V, 155F, 159P, 160L, 162F, 163A, 209F, 210S, 213M, 214T, 217G, 218G, 221S, 233M, 234A, 237S, 238A, 244P, 358Y, 361L, 362Y, 365F, 366F, 369P, 383T, 387F, 391A, 394V, 398S, 466G, 469F, 470L, 473Y, 477N, 478N, 481V, 491A, 492L, 495K, 496T, 499R, 500S, 503G
CDD
cd06174 (MFS)

Protein sequence

>MCA_01460_1
MNDPERNPQPFTKDDDTSSNSSNDIHPTKSLNEPRRITSAIDYAFEDPELAEAVSRIQTHLDPKHMETNEADPWKYHIDS
ETGARIVEFVEGDPENPMNWSKARKWFQTVNLGLICFMVAFASGVVTGDMEGPMVRFGVSMEVSILTVTLFVIGFGVGPL
VFAPFSEEFGRQIIYNTTLFIAIVFIVPCAVAKNIGTLLVARFISGVAFSAPMTLIGGSLSDIWRTEERGVAMAVFSAAP
FLGPVMGPLIGGYIGDYAGHYKHGNNTGWRWIYWVLLMFSGVVYIGALILIPETHHPTLLRRRAKKLIKDTGDDRYKVKE
DLVVKKFSSVMKIALFRPFQLFFELIVFLISIYMSVIYGLLYMFFFAYPVVFGEGKGWSSSKTGLTFIPIAVGVLLSSFL
APWINSDYNKRAKKYTDRGEVPPAELRLIPMMIGCWFVPVGLFIYAWTSYPRLIWVGPTLAGFPCGLGFLMLYNAANNYL
VDSYQHYAASALAAKTCVRSLWGAAVPLFTIQMYHRLGYEWASSLLAFISLACCAIPYAFYFYGARIRAKSKYAYDGF

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features