Protein
MIA_01697_1
Length
428 amino acids
Browser: contig02:1433513-1434916-
Protein function
| EGGNOG: | 0PIEM | FG00364.1 | NEDD8-activating enzyme E1 catalytic subunit |
|---|---|---|---|
| SGD closest match: | S000006270 | UBA3 | NEDD8-activating enzyme E1 catalytic subunit |
| CGD closest match: | CAL0000175918 | orf19.4209 | NEDD8-activating protein |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_01737_1 | 71.26% | 421 | 0.0 | MCA_01737_1 |
| A0A0J9XJ92_GEOCN | 68.43% | 415 | 0.0 | Similar to Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (Neddylation), which may play a role in protein degradation OS=Geotrichum candidum GN=BN980_GECA18s01891g PE=4 SV=1 |
| A0A060T383_BLAAD | 64.88% | 410 | 0.0 | ARAD1A07612p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A07612g PE=4 SV=1 |
| A0A1E3PR38_9ASCO | 62.71% | 413 | 0.0 | Putative NEDD8 activating enzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48543 PE=4 SV=1 |
| Q6C2Y1_YARLI | 62.22% | 405 | 0.0 | YALI0F04147p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04147g PE=4 SV=1 |
| UniRef50_Q6C2Y1 | 62.22% | 405 | 0.0 | YALI0F04147p n=20 Tax=Eukaryota TaxID=2759 RepID=Q6C2Y1_YARLI |
| A0A167DM27_9ASCO | 63.64% | 341 | 5e-172 | NEDD8-activating protein UBA3 OS=Sugiyamaella lignohabitans GN=UBA3 PE=4 SV=1 |
| A0A1E4TM17_9ASCO | 54.48% | 402 | 8e-161 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56359 PE=4 SV=1 |
| A0A1D8PPC6_CANAL | 60.49% | 329 | 3e-144 | NEDD8-activating protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4209 PE=4 SV=1 |
| UBA3_YEAST | 44.15% | 299 | 5e-82 | NEDD8-activating enzyme E1 catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBA3 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0336
Protein family membership
None predicted.
Domains and repeats
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Domain
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Domain
1
50
100
150
200
250
300
350
400
428
Detailed signature matches
no IPR
Unintegrated signatures
-
-
cd01488 (Uba3_RUB)
Residue annotation
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putative ATP bindi...
-
substrate interfac...
-
dimer interaction ...
-
zinc binding site ...
-
catalytic residue ...
Protein sequence
>MIA_01697_1 MTGNVKLEQQDVPDRNIKPLELLLSRRGPFTFEEFTPGIEVAQNLTKMKVLVIGAGGLGCEILKNLALSGFRDIHVIDLD TIDLSNLNRQFLFRKTDIGKSKAVVAAEFVNKRAKGVKVTPYFGKIQDKDIDYYMQFQLVICGLDNIEARRWINATLVSM VDENNPDTLKPLIDGGTEGLRGQSRVIIPTISSCFECSLDLLGPQVTFPICTIANTPRQPEHCVEYASVIEWDKVFPRQA IDGDNPEHISWLYETAKRRAAEFSITGVTYAMTQGIVKHIIPAVASTNAIIAASCCNEALKIATSANQYMNNYMMYAGDS SVYTFTYEYHRKPNCAVCGNNLKHIAVPGSKTLDEFIEMLGTHPDIKANKPSLRSESMSLYFQQPPQLEEMTRKNLTKRL DELIQNGEQVTVSDRDLPFPVIVKVQLT
GO term prediction
Biological Process
GO:0045116 protein neddylation
Molecular Function
GO:0005524 ATP binding
GO:0008641 small protein activating enzyme activity
GO:0016881 acid-amino acid ligase activity
Cellular Component
None predicted.