Protein
MCA_01737_1
Length
422 amino acids
Browser: contigA:5333442-5334838+
RNA-seq: read pairs 1760, FPKM 51.4, percentile rank 66.0% (100% = highest expression)
Protein function
| KEGG: | K10686 | UBE1C | ubiquitin-activating enzyme E1 C [EC:6.2.1.45] |
|---|---|---|---|
| EGGNOG: | 0PIEM | FG00364.1 | NEDD8-activating enzyme E1 catalytic subunit |
| SGD closest match: | S000006270 | UBA3 | NEDD8-activating enzyme E1 catalytic subunit |
| CGD closest match: | CAL0000175918 | orf19.4209 | NEDD8-activating protein |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01697_1 | 71.26% | 421 | 0.0 | MIA_01697_1 |
| A0A0J9XJ92_GEOCN | 69.12% | 421 | 0.0 | Similar to Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (Neddylation), which may play a role in protein degradation OS=Geotrichum candidum GN=BN980_GECA18s01891g PE=4 SV=1 |
| A0A060T383_BLAAD | 66.10% | 410 | 0.0 | ARAD1A07612p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A07612g PE=4 SV=1 |
| A0A1E3PR38_9ASCO | 65.50% | 400 | 0.0 | Putative NEDD8 activating enzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48543 PE=4 SV=1 |
| UniRef50_A0A1X2GPS8 | 64.18% | 388 | 0.0 | Uncharacterized protein n=1 Tax=Hesseltinella vesiculosa TaxID=101127 RepID=A0A1X2GPS8_9FUNG |
| Q6C2Y1_YARLI | 61.10% | 419 | 0.0 | YALI0F04147p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04147g PE=4 SV=1 |
| A0A167DM27_9ASCO | 65.04% | 349 | 4e-175 | NEDD8-activating protein UBA3 OS=Sugiyamaella lignohabitans GN=UBA3 PE=4 SV=1 |
| A0A1E4TM17_9ASCO | 57.89% | 399 | 6e-170 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56359 PE=4 SV=1 |
| A0A1D8PPC6_CANAL | 60.49% | 329 | 2e-146 | NEDD8-activating protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4209 PE=4 SV=1 |
| UBA3_YEAST | 42.86% | 301 | 3e-82 | NEDD8-activating enzyme E1 catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBA3 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0801
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
50
100
150
200
250
300
350
422
Detailed signature matches
no IPR
Unintegrated signatures
-
-
cd01488 (Uba3_RUB)
Residue annotation
-
putative ATP bindi...
-
substrate interfac...
-
dimer interaction ...
-
zinc binding site ...
-
catalytic residue ...
Protein sequence
>MCA_01737_1 MTETAIKSRSLAPLELLATRRGPTSFEEFTPCKEVITNLNNMKVLVIGAGGLGCEILKNLALSGFRNIHVIDMDTIDLSN LNRQFLFRKKDIGRSKAQVAAEFINKRVQGVTVTPFFGKIQDKPLDYYMGFSIVICGLDNIEARRWINATLVQMVDDSNP DSLKPLIDGGTEGFKGQARVILPTLTSCFECTLDLLGPQVNYPICTIANTPRLPEHCIEWASVIEWDRVHPDKKLDGDNP DHIQWLYETALARAKEFGIFGVTYSLTQGIVKHIIPAIASTNAVIAASCCNEALKLATSAAPYLNNYMMYAGDAGVYTYT YESQRKPDCPVCGNNKVYLTVKGDTTLLEFMDSLKNNSEVKANKPTLRGEANALYFQQPPQLEALTRKNLDKKMKDLITN GEIVAISDPELPFTVQVVITLV
GO term prediction
Biological Process
GO:0045116 protein neddylation
Molecular Function
GO:0005524 ATP binding
GO:0008641 small protein activating enzyme activity
GO:0016881 acid-amino acid ligase activity
Cellular Component
None predicted.