Protein

MIA_01689_1

Length
695 amino acids

Browser: contig02:1410797-1412931+

Protein function

EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000005908FRE3Ferric reductase transmembrane component 3
CGD closest match:CAL0000185898CFL4Ferric/cupric-chelate reductase

Protein alignments

%idAln lengthE-value
A0A0J9X3R7_GEOCN47.463%6700.0Similar to Saccharomyces cerevisiae YKL220C FRE2 Ferric reductase and cupric reductase OS=Geotrichum candidum GN=BN980_GECA01s05268g PE=4 SV=1
UniRef50_A0A0J9YHJ146.062%6730.0Similar to Saccharomyces cerevisiae YKL220C FRE2 Ferric reductase and cupric reductase n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHJ1_GEOCN
Q6CET4_YARLI41.748%6181.73e-155YALI0B13134p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13134g PE=4 SV=1
MCA_05581_134.126%7153.97e-126MCA_05581_1
A0A1E3PIN1_9ASCO32.851%6911.02e-123Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83263 PE=4 SV=1
A0A167BWN3_9ASCO35.921%5545.03e-123Fre3p OS=Sugiyamaella lignohabitans GN=FRE3 PE=4 SV=1
A0A060TAD4_BLAAD37.102%5661.77e-114ARAD1D26136p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26136g PE=4 SV=1
A0A1D8PN54_CANAL30.612%6861.57e-98Ferric/cupric-chelate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFL4 PE=4 SV=1
FRE3_YEAST31.725%6844.53e-97Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE3 PE=1 SV=1
A0A1E4TLJ4_9ASCO28.160%6255.97e-81Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30726 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5004

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 695

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  5. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
  6. SITE IPR018247
    EF-Hand 1, calcium-binding site
    1. PS00018 (EF_HAND_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SIGNAL_PEPTIDE (Sig...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. SIGNAL_PEPTID... (S...)
  11. SSF52343 (Ferredoxi...)
  12. SignalP-noTM
  13. TMhelix
  14. TRANSMEMBRANE (Tran...)
  15. cd06186 (NOX_Duox_l...)
  16. mobidb-lite (disord...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MIA_01689_1
MKKISVTSLTLLFSFLLSSSLVEAYKKHYVYMCQALIGEFDLGCGEEETFYACRCTSPVFMTSLINCLEDYNLTQKAVTR
EVSTIVYNCNEYGDINVTTDMVFEMYDENKDKIITVEEFGTNLTKPLTAPITFPAYNLTMAKKSITMFYWQLATGENYGG
IMLGYWCGVFLIATVLNFMGKMAPKVMLKMNSPALIKFRQMFVTPATFGFKHSTPIGCCKNIIAMATPTRAQSIIVGGYL
VMALILGMIKFQPFEPNVWFDDQHEQLIRYIADRCGLTALSQIPVIFLFAGRNNLLQYLTGFSFDTFNVFHRWIGRVMVF
FAFMHSVCYTWLERGYLAECFAETYWRWGVVATVTGCIMLGQSVYIFRSKIYEFFLAFHISLGVFFVIGMWYHLIELGWM
NWIYATIALWGFDRAARLGRLVWSGLGSAQTKLYPNDLFRMAIDYPRRWKTYPGAYVYVHVLSPWGFWESHPFTVYESAA
PGNEGKLMIGATVKGGMTKRVGKAVSKAGGDRAIRVLIDGPYGSSHEVARYDSVIFICGGIGVTAAFSYLKDIIDHKFHD
QHLVFVWVTRHASSLECFADELRFLARSDKCDVEIYVTSPDGAAASPASGRSSSDNEKKLADDGSDSSGSRYSVITGQRP
DVAALVPTYIGQSRGTTAVMVCGPPTLNDLTRRTVTDNLGRGKGRVDYFEEAFSW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.