Protein

MIA_01657_1

Length
692 amino acids

Browser: contig02:1321563-1323695+

Protein function

EGGNOG:0PJ78TOP3DNA Topoisomerase
SGD closest match:S000004224TOP3DNA topoisomerase 3
CGD closest match:CAL0000178060orf19.5934DNA topoisomerase

Protein alignments

%idAln lengthE-value
MCA_03981_159.879%6630.0MCA_03981_1
A0A0J9XKM4_GEOCN49.383%7290.0DNA topoisomerase OS=Geotrichum candidum GN=BN980_GECA24s00087g PE=3 SV=1
UniRef50_A0A0J9XKM449.383%7290.0DNA topoisomerase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKM4_GEOCN
A0A060T6F5_BLAAD47.734%6620.0DNA topoisomerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11726g PE=3 SV=1
Q6C0R0_YARLI44.870%6530.0DNA topoisomerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F22495g PE=3 SV=1
Q5ANG9_CANAL43.988%6570.0DNA topoisomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5934 PE=3 SV=1
TOP3_YEAST41.739%6902.00e-176DNA topoisomerase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP3 PE=1 SV=1
A0A1E4TD21_9ASCO42.687%6704.81e-168DNA topoisomerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_140658 PE=3 SV=1
A0A1E3PHR5_9ASCO48.333%4801.75e-152DNA topoisomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70460 PE=3 SV=1
A0A161HJL6_9ASCO51.163%3016.16e-98DNA topoisomerase OS=Sugiyamaella lignohabitans GN=TOP3 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3243
Predicted cleavage: 16

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
  4. Domain
1 100 200 300 400 500 600 692

Detailed signature matches

  1. Domain IPR006171
    TOPRIM domain
    1. PF01751 (Toprim)
    2. SM00493 (toprim5)
    3. PS50880 (TOPRIM)
  2. Domain IPR034144
    DNA topoisomerase 3-like, TOPRIM domain
    1. cd03362 (TOPRIM_Top...)
  3. Domain IPR023405
    DNA topoisomerase, type IA, core domain
    1. SSF56712 (Prokaryot...)
  4. Domain IPR013497
    DNA topoisomerase, type IA, central
    1. PR00417 (PRTPISMRASEI)
    2. PF01131 (Topoisom_bac)
    3. cd00186 (TOP1Ac)
  5. Domain IPR003601
    DNA topoisomerase, type IA, domain 2
    1. SM00436 (topIban2)
  6. Domain IPR003602
    DNA topoisomerase, type IA, DNA-binding domain
    1. SM00437 (topIaneu2)
  7. Domain IPR013825
    DNA topoisomerase, type IA, central region, subdomain 2
    1. G3DSA:2.70.20.10
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.46...
  2. G3DSA:3.40.50...
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd03362
  2. putative interdoma...
  3. putative metal-bin...
  4. putative nucleotid...
  5. domain I cd00186
  6. DNA binding groove...
  7. phosphate binding ...
  8. domain II cd00186
  9. domain III cd00186
  10. nucleotide binding...
  11. catalytic site cd0...
  12. domain IV cd00186

Protein sequence

>MIA_01657_1
MKILCVAEKPSVARGVATALSQERLQSRDSPNKYIKNFDFRFSFPDWGDCDVTVTSVLGHLNDTEFADPQYRNWRSVDPS
HLFNAPITTFTSESNKTVAKNIMNESRYAHKLFIWTDNDREGEHIGYEIFRIACSSNRNLTLSNVHRAVFNNIEGSHVRQ
AARNPRELDMKLVNAVMARIEIDFRIGTALTRFQTLAIQSAIIALKGDVISYGPCQFPTLGFVVDQYNRVAKFVPENFWY
ISIDAKMPQSFVDFQKEQQQNEDNNNSKGRKSSKKRIDVLKFTWSRTRLFDRAVAYVLFHRCINTGTQARVVNIRKVPTS
RWKPLPLTTVELQKVCSKFRGMTPKKVLDIAEKLYNKGFISYPRTETDVFDESIDLNKLVEKQFHSPDWGDYAKRLLGHT
QPPQPPTMCSPRKGKHNDKAHPPIHPVAFVNRSALENEDQWKIFEFIARRFLACVSPDAKGATTTITLDWGDETFFASGL
EVLERNFLEVYYPYQSWASSSVQIPPNLFSPGATIELDSADLLEGTTSPPRYLSETDLISLMDANGIGTDATMADHIQTI
IDRKYVNKIMSPGESGVSRLVPSALGYGLVEGYDKIGFEKSLSKPFLRKEMEESMVRIANGVSSKEEILRETLAKYYEVY
NIARRQVNVLVNTTKNNFERVVNMANDTANNSSNQRRGRNRSQSSTSRTIST

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity

Cellular Component

None predicted.