MCA_03981_1

Protein

Length

728 amino acids

Gene name: TOP3B

Description: DNA topoisomerase 3

Browser: contigC:1689733-1691992-

RNA-seq: read pairs 299, FPKM 5.1, percentile rank 17.5% (100% = highest expression)

Protein function

Annotation:		TOP3B	DNA topoisomerase 3
KEGG:	K03165	TOP3	DNA topoisomerase III [EC:5.99.1.2]
EGGNOG:	0PJ78	TOP3	DNA Topoisomerase
SGD closest match:	S000004224	TOP3	DNA topoisomerase 3
CGD closest match:	CAL0000178060	orf19.5934	DNA topoisomerase

Protein alignments

	%id	Aln length	E-value
MIA_01657_1	59.32%	676	0.0	MIA_01657_1
A0A0J9XKM4_GEOCN	49.86%	740	0.0	DNA topoisomerase OS=Geotrichum candidum GN=BN980_GECA24s00087g PE=3 SV=1
UniRef50_A0A0J9XKM4	49.86%	740	0.0	DNA topoisomerase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKM4_GEOCN
A0A060T6F5_BLAAD	47.97%	665	0.0	DNA topoisomerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11726g PE=3 SV=1
Q5ANG9_CANAL	46.76%	663	0.0	DNA topoisomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5934 PE=3 SV=1
TOP3_YEAST	45.40%	685	0.0	DNA topoisomerase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP3 PE=1 SV=1
Q6C0R0_YARLI	43.69%	650	0.0	DNA topoisomerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F22495g PE=3 SV=1
A0A1E4TD21_9ASCO	43.67%	664	5e-169	DNA topoisomerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_140658 PE=3 SV=1
A0A1E3PHR5_9ASCO	48.33%	478	1e-150	DNA topoisomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70460 PE=3 SV=1
A0A161HJL6_9ASCO	53.67%	300	6e-105	DNA topoisomerase OS=Sugiyamaella lignohabitans GN=TOP3 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7397
Predicted cleavage: 26

Protein family membership

None predicted.

Domains and repeats

Domain
2 - 647
DNA topoisomerase, type IA, core domain (IPR023405)
Domain
2 - 164
TOPRIM domain (IPR006171)
DNA topoisomerase 3-like, TOPRIM domain (IPR034144)
314 - 582
DNA topoisomerase, type IA, DNA-binding domain (IPR003602)
Domain
111 - 124
DNA topoisomerase, type IA, central (IPR013497)
167 - 642
DNA topoisomerase, type IA, central (IPR013497)
Domain
143 - 239
DNA topoisomerase, type IA, domain 2 (IPR003601)
408 - 516
DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825)

1 100 200 300 400 500 600 728

Detailed signature matches

IPR006171

TOPRIM domain
1. PF01751 (Toprim)
  
  4 - 151
  
  Pfam
  PF01751 (Toprim)
2. SM00493 (toprim5)
  
  2 - 137
  
  SMART
  SM00493 (toprim5)
3. PS50880 (TOPRIM)
  
  2 - 147
  
  PROSITE profiles
  PS50880 (TOPRIM)
IPR034144

DNA topoisomerase 3-like, TOPRIM domain
1. cd03362 (TOPRIM_Top...)
  
  2 - 164
  
  CDD
  cd03362 (TOPRIM_TopoIA_TopoIII)
IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  2 - 647
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR013497

DNA topoisomerase, type IA, central
1. PR00417 (PRTPISMRASEI)
  
  547 - 561
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  444 - 460
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  111 - 124
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  209 - 227
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  357 - 366
  
  PRINTS
  PR00417 (PRTPISMRASEI)
2. PF01131 (Topoisom_bac)
  
  167 - 631
  
  Pfam
  PF01131 (Topoisom_bac)
3. cd00186 (TOP1Ac)
  
  174 - 642
  
  CDD
  cd00186 (TOP1Ac)
IPR003601

DNA topoisomerase, type IA, domain 2
1. SM00436 (topIban2)
  
  143 - 239
  
  SMART
  SM00436 (topIban2)
IPR003602

DNA topoisomerase, type IA, DNA-binding domain
1. SM00437 (topIaneu2)
  
  314 - 582
  
  SMART
  SM00437 (topIaneu2)
IPR013825

DNA topoisomerase, type IA, central region, subdomain 2
1. G3DSA:2.70.20.10
  
  408 - 516
  
  GENE3D
  G3DSA:2.70.20.10 (G3DSA:2.70.20.10)

no IPR

Unintegrated signatures

G3DSA:1.10.46...

174 - 383

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)

517 - 704

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
G3DSA:3.40.50...

1 - 173

GENE3D
G3DSA:3.40.50.140 (G3DSA:3.40.50.140)
mobidb-lite (disord...)

666 - 728

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd03362

8E

active site
8E, 9K, 12V, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

9K

active site
8E, 9K, 12V, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

12V

active site
8E, 9K, 12V, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

116D

active site
8E, 9K, 12V, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

118D

active site
8E, 9K, 12V, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

120E

active site
8E, 9K, 12V, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
putative interdoma...

15G

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

117N

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

119R

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

126Y

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

127E

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

129L

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

130D

putative interdomain interaction site
15G, 117N, 119R, 126Y, 127E, 129L, 130D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
putative metal-bin...

116D

putative metal-binding site
116D, 118D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

118D

putative metal-binding site
116D, 118D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
putative nucleotid...

119R

putative nucleotide binding site
119R
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
domain I cd00186

174A

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

175V

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

176Q

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

177T

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

178R

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

179I

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

180E

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

181I

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

182D

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

183F

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

184R

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

185I

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

186G

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

187T

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

188A

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

189L

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

190T

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

191R

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

192F

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

193Q

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

194T

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

195V

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

196E

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

209V

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

210S

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

211Y

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

212G

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

213P

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

214C

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

215Q

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

216F

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

217P

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

218T

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

219L

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

220G

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

221F

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

222I

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

223V

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

224D

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

225Q

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

226Y

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

227K

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

228R

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)

229V

domain I
174A, 175V, 176Q, 177T, 178R, 179I, 180E, 181I, 182D, 183F, 184R, 185I, 186G, 187T, 188A, 189L, 190T, 191R, 192F, 193Q, 194T, 195V, 196E, 209V, 210S, 211Y, 212G, 213P, 214C, 215Q, 216F, 217P, 218T, 219L, 220G, 221F, 222I, 223V, 224D, 225Q, 226Y, 227K, 228R, 229V
CDD
cd00186 (TOP1Ac)
DNA binding groove...

178R

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

179I

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

182D

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

186G

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

190T

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

352E

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

356N

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

364R

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

552A

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

553T

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

556D

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

557H

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

559E

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

563K

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)

564R

DNA binding groove
178R, 179I, 182D, 186G, 190T, 352E, 356N, 364R, 552A, 553T, 556D, 557H, 559E, 563K, 564R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

220G

phosphate binding site
220G, 224D, 596D
CDD
cd00186 (TOP1Ac)

224D

phosphate binding site
220G, 224D, 596D
CDD
cd00186 (TOP1Ac)

596D

phosphate binding site
220G, 224D, 596D
CDD
cd00186 (TOP1Ac)
domain II cd00186

234S

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

235E

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

236K

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

237F

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

238W

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

239Y

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

240I

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

241S

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

307K

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

308A

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

309I

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

310V

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

311H

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

312D

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

313V

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

314I

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

315E

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

316K

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

317P

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

318T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

319T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

320C

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

321Y

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

458P

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

459D

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

460A

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

461K

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

462G

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

463S

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

464R

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

465T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

466T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

467I

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

468I

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

469L

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

470D

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

471W

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

472A

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

474E

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

475R

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

476F

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

477L

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

478T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

479S

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

480G

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

481L

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

482I

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

483V

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

484L

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

485E

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

486R

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

487N

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

488F

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

489L

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

490D

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

491V

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

492Y

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

519H

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

520T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

521A

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

522N

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

523L

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

524E

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

525S

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

526G

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

527D

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

528T

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)

529S

domain II
234S, 235E, 236K, 237F, 238W, 239Y, 240I, 241S, 307K, 308A, 309I, 310V, 311H, 312D, 313V, 314I, 315E, 316K, 317P, 318T, 319T, 320C, 321Y, 458P, 459D, 460A, 461K, 462G, 463S, 464R, 465T, 466T, 467I, 468I, 469L, 470D, 471W, 472A, 474E, 475R, 476F, 477L, 478T, 479S, 480G, 481L, 482I, 483V, 484L, 485E, 486R, 487N, 488F, 489L, 490D, 491V, 492Y, 519H, 520T, 521A, 522N, 523L, 524E, 525S, 526G, 527D, 528T, 529S
CDD
cd00186 (TOP1Ac)
domain III cd00186

322R

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

323P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

324L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

325P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

326L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

327T

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

328T

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

330E

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

331L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

332Q

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

333K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

334V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

335C

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

336S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

337R

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

338A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

339F

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

341G

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

342M

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

343S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

344A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

345K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

346Q

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

347V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

348L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

349D

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

350I

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

351A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

352E

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

353K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

354L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

355Y

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

356N

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

357K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

358G

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

359F

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

360I

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

361S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

362Y

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

363P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

364R

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

365T

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

366E

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

367T

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

368D

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

369V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

370F

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

371D

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

372P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

373S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

374V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

375D

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

376L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

377K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

378S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

379L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

380V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

381S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

382K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

383Q

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

384F

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

385N

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

386S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

422A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

423H

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

424P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

425P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

426I

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

427H

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

428P

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

437L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

438T

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

439A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

440D

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

441E

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

442W

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

443K

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

444V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

445Y

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

446E

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

447F

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

448V

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

449A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

450R

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

451R

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

452F

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

453L

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

454A

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

455C

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

456C

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)

457S

domain III
322R, 323P, 324L, 325P, 326L, 327T, 328T, 330E, 331L, 332Q, 333K, 334V, 335C, 336S, 337R, 338A, 339F, 341G, 342M, 343S, 344A, 345K, 346Q, 347V, 348L, 349D, 350I, 351A, 352E, 353K, 354L, 355Y, 356N, 357K, 358G, 359F, 360I, 361S, 362Y, 363P, 364R, 365T, 366E, 367T, 368D, 369V, 370F, 371D, 372P, 373S, 374V, 375D, 376L, 377K, 378S, 379L, 380V, 381S, 382K, 383Q, 384F, 385N, 386S, 422A, 423H, 424P, 425P, 426I, 427H, 428P, 437L, 438T, 439A, 440D, 441E, 442W, 443K, 444V, 445Y, 446E, 447F, 448V, 449A, 450R, 451R, 452F, 453L, 454A, 455C, 456C, 457S
CDD
cd00186 (TOP1Ac)
nucleotide binding...

333K

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

337R

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

338A

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

339F

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

423H

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

443K

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

446E

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

450R

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

550T

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

552A

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)

582L

nucleotide binding site
333K, 337R, 338A, 339F, 423H, 443K, 446E, 450R, 550T, 552A, 582L
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

362Y

catalytic site
362Y, 364R, 423H
CDD
cd00186 (TOP1Ac)

364R

catalytic site
362Y, 364R, 423H
CDD
cd00186 (TOP1Ac)

423H

catalytic site
362Y, 364R, 423H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

530P

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

531P

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

532K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

533Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

534L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

535T

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

536E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

537P

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

538D

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

539L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

540I

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

541A

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

542L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

543M

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

544D

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

545A

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

546N

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

547G

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

548I

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

549G

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

550T

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

551D

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

552A

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

553T

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

554M

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

555A

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

556D

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

557H

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

558I

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

559E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

560T

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

561I

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

562L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

563K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

564R

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

565E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

566Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

567A

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

568V

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

569K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

570Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

582L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

583L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

584P

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

585S

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

586A

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

587L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

588G

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

589Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

590G

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

591L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

592V

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

593E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

594G

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

595Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

596D

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

604L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

605S

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

606K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

607P

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

608F

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

609L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

610R

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

611K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

612E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

613M

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

614E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

615E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

616L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

617M

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

618K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

619N

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

620I

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

621E

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

622Q

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

623G

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

624R

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

625M

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

626T

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

627K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

628Q

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

629Q

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

630V

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

631L

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

632R

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

633D

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

634T

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

635I

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

636N

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

637K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

638Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

639F

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

640K

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

641V

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

642Y

domain IV
530P, 531P, 532K, 533Y, 534L, 535T, 536E, 537P, 538D, 539L, 540I, 541A, 542L, 543M, 544D, 545A, 546N, 547G, 548I, 549G, 550T, 551D, 552A, 553T, 554M, 555A, 556D, 557H, 558I, 559E, 560T, 561I, 562L, 563K, 564R, 565E, 566Y, 567A, 568V, 569K, 570Y, 582L, 583L, 584P, 585S, 586A, 587L, 588G, 589Y, 590G, 591L, 592V, 593E, 594G, 595Y, 596D, 604L, 605S, 606K, 607P, 608F, 609L, 610R, 611K, 612E, 613M, 614E, 615E, 616L, 617M, 618K, 619N, 620I, 621E, 622Q, 623G, 624R, 625M, 626T, 627K, 628Q, 629Q, 630V, 631L, 632R, 633D, 634T, 635I, 636N, 637K, 638Y, 639F, 640K, 641V, 642Y
CDD
cd00186 (TOP1Ac)

Protein sequence

>MCA_03981_1
MKILCVTEKPSVAKGVVGALSGGRYQTRNSRNKYIKNYDFDYTFPQWGRCSVTVTSVLGHLNSVDVVDPQLTSWQVDPGL
LFNTRLKTIVPDSNKDVVSNIQAESRNADYLYIWTDNDREGEHIGYEILDAARKTNPRLTDEYVKRAVFNNLDPGHVKRA
AYNPRDLDFKTIAAVQTRIEIDFRIGTALTRFQTVELQKRMAQFQGKVVSYGPCQFPTLGFIVDQYKRVKNFVSEKFWYI
SMTVKIPPTIMAQIRLESEAQDAANDSSKRKKKKISDILQFKWSRYHLFDQLAVTIFFDRCVQSGDKAIVHDVIEKPTTC
YRPLPLTTVELQKVCSRAFRGMSAKQVLDIAEKLYNKGFISYPRTETDVFDPSVDLKSLVSKQFNSPEWGNYAKDLLDEG
LSRRPGAPTFTTPRKGKHNDAAHPPIHPIIYASRSVLTADEWKVYEFVARRFLACCSPDAKGSRTTIILDWAQERFLTSG
LIVLERNFLDVYYPYQSWESSATQIPRDMFQRGQEIKIHTANLESGDTSPPKYLTEPDLIALMDANGIGTDATMADHIET
ILKREYAVKYKESQSSTAIPVLLPSALGYGLVEGYDQIGFEMSLSKPFLRKEMEELMKNIEQGRMTKQQVLRDTINKYFK
VYGIAKRNQNILIECTKNRIEMAAQSTQNSQGVVQNSTSSNTSTSGTTRSTSTRSASTRGARGTRGTRVSRRGSTTRRRG
RSTSSRGS

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity

Cellular Component