MIA_01645_1

Protein

Length

262 amino acids

Protein function

EGGNOG:	0PHEW	SDH2	succinate dehydrogenase
SGD closest match:	S000003964	SDH2	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CGD closest match:	CAL0000198657	SDH2	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Protein alignments

	%id	Aln length	E-value
MCA_00313_1	91.561%	237	3.81e-168	MCA_00313_1
A0A0J9XIV1_GEOCN	85.774%	239	8.40e-161	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Geotrichum candidum GN=BN980_GECA17s01968g PE=3 SV=1
Q6C823_YARLI	84.937%	239	3.28e-157	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23397g PE=3 SV=1
A0A1E4TJV0_9ASCO	82.008%	239	1.39e-155	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30286 PE=3 SV=1
A0A1E3PJ24_9ASCO	84.255%	235	7.90e-155	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83420 PE=3 SV=1
A0A167F5K0_9ASCO	83.761%	234	3.95e-151	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Sugiyamaella lignohabitans GN=SDH2 PE=3 SV=1
Q59QN7_CANAL	81.013%	237	3.07e-151	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SDH2 PE=3 SV=1
UniRef50_A5DJ38	79.832%	238	4.76e-147	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial n=144 Tax=cellular organisms TaxID=131567 RepID=A5DJ38_PICGU
SDHB_YEAST	76.695%	236	9.38e-144	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SDH2 PE=1 SV=1
A0A060T220_BLAAD	75.732%	239	1.45e-142	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25652g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9924
Predicted cleavage: 37

Protein family membership

Succinate dehydrogenase/fumarate reductase iron-sulphur protein (IPR004489)

Domains and repeats

Domain
18 - 136
Beta-grasp domain (IPR012675)
2Fe-2S ferredoxin-type iron-sulfur binding domain (IPR001041)
Succinate dehydogenase/fumarate reductase N-terminal (IPR025192)
164 - 194
4Fe-4S ferredoxin-type, iron-sulphur binding domain (IPR017896)
Domain
133 - 257
Alpha-helical ferredoxin (IPR009051)

1 50 100 150 200 262

Detailed signature matches

IPR004489

Succinate dehydrogenase/fumarate reductase iron-sulphur protein
1. TIGR00384
  
  33 - 255
  
  TIGRFAMs
  TIGR00384 (TIGR00384)
IPR012675

Beta-grasp domain
1. G3DSA:3.10.20.30
  
  18 - 131
  
  GENE3D
  G3DSA:3.10.20.30 (G3DSA:3.10.20.30)
IPR001041

2Fe-2S ferredoxin-type iron-sulfur binding domain
1. SSF54292 (2Fe-2S fe...)
  
  27 - 131
  
  SUPERFAMILY
  SSF54292 (2Fe-2S ferredoxin-like)
2. cd00207 (fer2)
  
  45 - 110
  
  CDD
  cd00207 (fer2)
3. PS51085 (2FE2S_FER_2)
  
  31 - 122
  
  PROSITE profiles
  PS51085 (2FE2S_FER_2)
IPR025192

Succinate dehydogenase/fumarate reductase N-terminal
1. PF13085 (Fer2_3)
  
  30 - 136
  
  Pfam
  PF13085 (Fer2_3)
IPR009051

Alpha-helical ferredoxin
1. SSF46548 (alpha-hel...)
  
  133 - 257
  
  SUPERFAMILY
  SSF46548 (alpha-helical ferredoxin)
IPR017896

4Fe-4S ferredoxin-type, iron-sulphur binding domain
1. PS51379 (4FE4S_FER_2)
  
  164 - 194
  
  PROSITE profiles
  PS51379 (4FE4S_FER_2)
IPR006058

2Fe-2S ferredoxin, iron-sulphur binding site
1. PS00197 (2FE2S_FER_1)
  
  82 - 90
  
  PROSITE patterns
  PS00197 (2FE2S_FER_1)
IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site
1. PS00198 (4FE4S_FER_1)
  
  174 - 185
  
  PROSITE patterns
  PS00198 (4FE4S_FER_1)

no IPR

Unintegrated signatures

G3DSA:1.10.10...

132 - 261

GENE3D
G3DSA:1.10.1060.10 (G3DSA:1.10.1060.10)
PF13534 (Fer4_17)

173 - 246

Pfam
PF13534 (Fer4_17)

Residue annotation

catalytic loop cd0...

78F

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

79R

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

82C

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

85G

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

87C

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

88G

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

89S

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

90C

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

101A

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)

102C

catalytic loop
78F, 79R, 82C, 85G, 87C, 88G, 89S, 90C, 101A, 102C
CDD
cd00207 (fer2)
iron binding site ...

82C

iron binding site
82C, 87C, 90C, 102C
CDD
cd00207 (fer2)

87C

iron binding site
82C, 87C, 90C, 102C
CDD
cd00207 (fer2)

90C

iron binding site
82C, 87C, 90C, 102C
CDD
cd00207 (fer2)

102C

iron binding site
82C, 87C, 90C, 102C
CDD
cd00207 (fer2)

Protein sequence

>MIA_01645_1
MIAPALRLVRAPAARTMATAATVKPPRIKKFQIYRWNPDTPEKKPELKTYEVNLSECGPMVLDALLKIKNEQDATLTFRR
SCREGICGSCAMNIDGNNTLACLCRIDTNLAKPKKIYPLPHMFVVRDLVPDLTHFYKQYKSIEPYLQRSEVPADGKENLQ
TIEDRKKLDGLYECILCACCSTSCPSYWWNSAEYLGPAVLMQAFRWMIDSRDEHGEHRRDRLQNSMSLYRCHTIMNCSRT
CPKGLNPGLAIAKIKKSMSFTA

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0055114 oxidation-reduction process

Molecular Function

GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding

Cellular Component

None predicted.

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Status

Per-residue features