Protein

MCA_00313_1

Length
269 amino acids

Gene name: SDH2

Description: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Browser: contigA:958409-959219-

RNA-seq: read pairs 18308, FPKM 837.8, percentile rank 96.1% (100% = highest expression)

Protein function

Annotation:SDH2Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
KEGG:K00235SDHB succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
EGGNOG:0PHEWSDH2succinate dehydrogenase
SGD closest match:S000003964SDH2Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CGD closest match:CAL0000198657SDH2Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Protein alignments

%idAln lengthE-value
MIA_01645_191.56%2372e-166MIA_01645_1
Q6C823_YARLI82.53%2692e-160Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23397g PE=3 SV=1
A0A0J9XIV1_GEOCN82.03%2561e-160Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Geotrichum candidum GN=BN980_GECA17s01968g PE=3 SV=1
A0A1E3PJ24_9ASCO77.19%2631e-154Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83420 PE=3 SV=1
Q59QN7_CANAL79.44%2484e-153Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SDH2 PE=3 SV=1
A0A1E4TJV0_9ASCO81.74%2416e-153Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30286 PE=3 SV=1
UniRef50_A5DJ3880.16%2474e-148Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial n=144 Tax=cellular organisms TaxID=131567 RepID=A5DJ38_PICGU
A0A167F5K0_9ASCO82.05%2344e-147Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Sugiyamaella lignohabitans GN=SDH2 PE=3 SV=1
SDHB_YEAST79.15%2359e-146Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SDH2 PE=1 SV=1
A0A060T220_BLAAD73.44%2569e-145Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25652g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8886
Predicted cleavage: 46

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 269

Detailed signature matches

  1. Family IPR004489
    Succinate dehydrogenase/fumarate reductase iron-sulphur protein
    1. TIGR00384
  2. Domain IPR012675
    Beta-grasp domain
    1. G3DSA:3.10.20.30
  3. Domain IPR001041
    2Fe-2S ferredoxin-type iron-sulfur binding domain
    1. SSF54292 (2Fe-2S fe...)
    2. cd00207 (fer2)
    3. PS51085 (2FE2S_FER_2)
  4. Domain IPR025192
    Succinate dehydogenase/fumarate reductase N-terminal
    1. PF13085 (Fer2_3)
  5. Domain IPR009051
    Alpha-helical ferredoxin
    1. SSF46548 (alpha-hel...)
  6. Domain IPR017896
    4Fe-4S ferredoxin-type, iron-sulphur binding domain
    1. PS51379 (4FE4S_FER_2)
  7. SITE IPR006058
    2Fe-2S ferredoxin, iron-sulphur binding site
    1. PS00197 (2FE2S_FER_1)
  8. SITE IPR017900
    4Fe-4S ferredoxin, iron-sulphur binding, conserved site
    1. PS00198 (4FE4S_FER_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.10...
  2. PF13534 (Fer4_17)

Residue annotation

  1. catalytic loop cd0...
  2. iron binding site ...

Protein sequence

>MCA_00313_1
MIVPSLRISAARLTAPRFAVPAIRGLATASTEKAPRIKKFQIYRWNPDEPAKKPELKEYEVDLNQCGPMVLDAIIKIKNE
QDSTLTFRRSCREGICGSCAMNIDGNNTLACLCRIDTNLSKPKKIYPLPHMFVVRDLVPDLTQFYKQYKSIEPYLQRSEV
PADGKENLQSIADRKKLDGLYECILCACCSTSCPSYWWNQAEYLGPAVLMQAYRWMIDSRDEMGAARRDRLDNSMSLYRC
HTIMNCSRTCPKGLNPGLAIAKIKKSMSF

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0055114 oxidation-reduction process

Molecular Function

GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding

Cellular Component

None predicted.