Protein

MIA_01565_1

Length
917 amino acids

Browser: contig02:1087543-1090462-

Protein function

EGGNOG:0PFBCVPS34Phosphatidylinositol 3-kinase
SGD closest match:S000004230VPS34Phosphatidylinositol 3-kinase VPS34
CGD closest match:CAL0000195103VPS34Phosphatidylinositol 3-kinase

Protein alignments

%idAln lengthE-value
MCA_03668_163.399%9590.0MCA_03668_1
UniRef50_UPI00071988DD40.184%9780.0phosphatidylinositol 3-kinase n=1 Tax=Pseudozyma antarctica TaxID=84753 RepID=UPI00071988DD
A0A0J9X2E9_GEOCN49.752%6053.49e-177Similar to Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate OS=Geotrichum candidum GN=BN980_GECA01s00571g PE=3 SV=1
A0A1D8PDV7_CANAL37.109%10243.69e-173Phosphatidylinositol 3-kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS34 PE=3 SV=1
A0A167CFY5_9ASCO47.541%6101.13e-164Phosphatidylinositol 3-kinase VPS34 OS=Sugiyamaella lignohabitans GN=VPS34 PE=3 SV=1
A0A060TBU9_BLAAD45.409%5993.27e-157ARAD1B11462p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11462g PE=3 SV=1
A0A1E3PF34_9ASCO43.040%6251.75e-145Phosphatidylinositol 3-kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53175 PE=3 SV=1
Q6C299_YARLI73.358%2741.23e-134YALI0F09559p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09559g PE=3 SV=2
A0A1E4TB73_9ASCO68.217%2583.06e-123Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_132969 PE=3 SV=1
VPS34_YEAST68.340%2591.18e-120Phosphatidylinositol 3-kinase VPS34 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS34 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2627

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 917

Detailed signature matches

  1. Domain IPR000008
    C2 domain
    1. G3DSA:2.60.40...
    2. SSF49562 (C2 domain...)
  2. Domain IPR002420
    Phosphatidylinositol 3-kinase, C2 domain
    1. PS51547 (PI3K_C2)
    2. PF00792 (PI3K_C2)
  3. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  4. Domain IPR001263
    Phosphoinositide 3-kinase, accessory (PIK) domain
    1. PF00613 (PI3Ka)
    2. SM00145 (pi3k_hr2_4)
    3. PS51545 (PIK_HELICAL)
  5. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  6. Domain IPR000403
    Phosphatidylinositol 3-/4-kinase, catalytic domain
    1. PS50290 (PI3_4_KINA...)
    2. SM00146 (pi3k_hr1_6)
    3. PF00454 (PI3_PI4_ki...)
    4. G3DSA:1.10.10...
  7. SITE IPR018936
    Phosphatidylinositol 3/4-kinase, conserved site
    1. PS00916 (PI3_4_KINA...)
    2. PS00915 (PI3_4_KINA...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.25.40.70
  2. G3DSA:3.30.10...
  3. PIRSF000587 (PI3K_V...)
  4. cd00870 (PI3Ka_III)
  5. cd00896 (PI3Kc_III)
  6. cd08397 (C2_PI3K_cl...)
  7. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. catalytic loop cd0...
  3. activation loop (A...

Protein sequence

>MIA_01565_1
MVTVQLFADSKPLTNPVATRHKEFKLTRKWDQWLTLPIRYSELMYSSQLAITLWDLAGDQQLIPYGGTTIKLFDETDCSL
KTGLQRLKVWLDQPADGLSNTSTPSTLIPTDELRRIDARVKQLSTSKIPKVDWLDKFVSRKIQQMDNDMSQQIGDQILFI
EFTYFEAPVVFSDYLYPQPPLLPLQGNTLEGSESSYSNGSSTQYPTGGAYRNGDTNNTIYNDYPSPETLMQVIVDPEQFR
ENQIERKHRRLNRGKEAGPFDKDLKPSAKIRDDINKIISYSPVHELTNEEKDKLWKFRYYLTRHKQALTKFLKTITWEDP
LEVKQAIDLLPRWTQIDVDDALELLGPNFHHPAVRAYAVNRLRQASDHELELYLLQLVQALRFEKPSRTLSSTSLNSSSS
SAYNPIRKKSSLAKFLINRAVRNPILGNYFFWYVSVESQEKGAPSIFMYVLKHFQAALKNQEEEAAAAVVAPADHDSSQS
EQLPTPTPLPQPSMLKTLERQIKFIDRLLKVATEIKTAKDPRPKKIEKLQQYISDSKNGLLRFDPIPLPLDPSVTIVGCV
PEDCTVFKSSLSPLKITLKTIPSSLALELHQQKHRHKHRHNSESAAPQSTSSSVATLRITSTSSSTATLEDTTDSLRHSR
HSEQSHGLDKIPEESFGTYSIMFKTGDDLRQDQLVIQIITLMDQLLRNENLDLKLTPYRILATGPRDGALQFVVNKTLDN
VLADYNGGILGYLRDHNPDSTTALGVTDECMDTYVRSCAGYCVITYILGVGDRHLDNLLICPDGHFFHADFGYILGHDPK
PFPPLMKLPIQIIDGMGGINSENYSRFRSLCFTAYTTLRKSANLILNLFALMSHSSIPDIMVERDNAAVLKVMEKFCLDM
TEEEAIMHFQNLINDSVNAFLPIVIDRLHSLAQYWRA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0016301 kinase activity

Cellular Component

None predicted.