Protein

MCA_03668_1

Length
998 amino acids

Gene name: VPS34

Description: Phosphatidylinositol 3-kinase VPS34

Browser: contigC:733399-736632+

RNA-seq: read pairs 5240, FPKM 64.8, percentile rank 70.8% (100% = highest expression)

Protein function

Annotation:VPS34Phosphatidylinositol 3-kinase VPS34
KEGG:K00914PIK3C3 phosphatidylinositol 3-kinase [EC:2.7.1.137]
EGGNOG:0PFBCVPS34Phosphatidylinositol 3-kinase
SGD closest match:S000004230VPS34Phosphatidylinositol 3-kinase VPS34
CGD closest match:CAL0000195103VPS34Phosphatidylinositol 3-kinase

Protein alignments

%idAln lengthE-value
UniRef50_A0A0F7SDY839.75%10240.0Related to phosphatidylinositol 3-kinase n=5 Tax=Ustilaginaceae TaxID=5268 RepID=A0A0F7SDY8_9BASI
MIA_01565_158.94%6040.0MIA_01565_1
A0A0J9X2E9_GEOCN49.70%6740.0Similar to Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate OS=Geotrichum candidum GN=BN980_GECA01s00571g PE=3 SV=1
A0A167CFY5_9ASCO46.33%6133e-160Phosphatidylinositol 3-kinase VPS34 OS=Sugiyamaella lignohabitans GN=VPS34 PE=3 SV=1
A0A1E3PF34_9ASCO41.49%6701e-151Phosphatidylinositol 3-kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53175 PE=3 SV=1
A0A060TBU9_BLAAD78.93%2613e-140ARAD1B11462p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11462g PE=3 SV=1
Q6C299_YARLI72.12%2699e-129YALI0F09559p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09559g PE=3 SV=2
A0A1E4TB73_9ASCO67.18%2592e-119Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_132969 PE=3 SV=1
VPS34_YEAST66.80%2597e-117Phosphatidylinositol 3-kinase VPS34 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS34 PE=1 SV=1
A0A1D8PDV7_CANAL60.44%3167e-112Phosphatidylinositol 3-kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS34 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0932

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 998

Detailed signature matches

  1. Domain IPR000008
    C2 domain
    1. SSF49562 (C2 domain...)
    2. G3DSA:2.60.40...
  2. Domain IPR002420
    Phosphatidylinositol 3-kinase, C2 domain
    1. PS51547 (PI3K_C2)
    2. PF00792 (PI3K_C2)
    3. SM00142 (pi3k_hr3_6)
  3. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  4. Domain IPR001263
    Phosphoinositide 3-kinase, accessory (PIK) domain
    1. PF00613 (PI3Ka)
    2. SM00145 (pi3k_hr2_4)
    3. PS51545 (PIK_HELICAL)
  5. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  6. Domain IPR000403
    Phosphatidylinositol 3-/4-kinase, catalytic domain
    1. PS50290 (PI3_4_KINA...)
    2. SM00146 (pi3k_hr1_6)
    3. PF00454 (PI3_PI4_ki...)
    4. G3DSA:1.10.10...
  7. SITE IPR018936
    Phosphatidylinositol 3/4-kinase, conserved site
    1. PS00916 (PI3_4_KINA...)
    2. PS00915 (PI3_4_KINA...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.25.40.70
  2. G3DSA:3.30.10...
  3. PIRSF000587 (PI3K_V...)
  4. cd00870 (PI3Ka_III)
  5. cd00896 (PI3Kc_III)
  6. cd08397 (C2_PI3K_cl...)
  7. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. catalytic loop cd0...
  3. activation loop (A...

Protein sequence

>MCA_03668_1
MDKDKVSFCHLRDVTIPFRVKIVSLEGEKPLLKPSQLIEDPEKLLTLSNTDPNSDLLVSAQIFADNKPLTIPVYTKYKNL
SEKREWKEWLTLPIRYSELMINSQLAITIWDLAGNQRLVPYGGTTIKLFEDSDCTLKRGRQRLKVWPNQIADGKDESSTP
STVLSIKELDRVESLMKKHMENEMPVIGWLDAYTFRKLEQINHSSIAENDSKGQYLFVELVQFDVPIVFSDILYPQPPMV
PTLPQQHGSYMDGSETLQLQYTDSPTIYPSANSNYKWKMINKKGRINTSEMEEGYQDSDRLRSNAMYNNSTYNDHPATDA
PLIRVIDPDQFRENQIERKHRRLNRGAETGLFDKDLKPSATIRDDINKIIGYSPVHELTSEEKDKLWKFRYYITRHKQAL
TKFLKTISWEDPREVKQAIDLLPRWTQIDIDDALELLGPNFHHPTVRAYAVNRLKIASDHELELYLLQLVQALRFEKSSS
YSSPSTSSLLNSYQHEAPKSKSSSLAKFLISRAVKNPILGNYFFWYVTVESQEKGAPSIFKNVLNQFQKALKTQEKLNLA
ATVAEFGGSEETASNNSTFLSILENQIEFINKLLKVATQVKGSKDPRPKKIEKLKQYIADPKNGLLNFAPIPLPLDPTVT
IVGIVPEDCTVFKSSLSPLKLTLKTITMNLFEPKSQNTTTTDNLGSNDDSNNSNSVETIQHSTIIPPPNQKHHHTKGKSK
ARASSVASASSSTSNSYDTYSIMFKTGDDLRQDQLVIQIITLMDQLLRNENLDLKLTPYRILATGPRDGALQFVLNRTLN
NVLAEYSNGILGYLRDHNPDSTNPLGVTEQAMDTYIRSCAGYCVITYILGVGDRHLDNLLICPDGHFFHADFGYILGHDP
KPFPPMMKLPIQIIDGMGGINSANYGKFKNYCFSAYTTLRKSANLILNLFALMSHSTIPDIMVERDNAAVLKVMEKFCLD
MTEEEAILHFQNLINDSVNAFLPVVIDRFHSLAQYWRA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0016301 kinase activity

Cellular Component

None predicted.