MIA_01564_1

Protein

Length

377 amino acids

Protein function

EGGNOG:	0PFQF	FLD1	Dehydrogenase
SGD closest match:	S000002327	SFA1	S-(hydroxymethyl)glutathione dehydrogenase
CGD closest match:	CAL0000175789	FDH3	S-(hydroxymethyl)glutathione dehydrogenase

Protein alignments

	%id	Aln length	E-value
A0A0J9X4U2_GEOCN	86.898%	374	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Geotrichum candidum GN=BN980_GECA02s00736g PE=3 SV=1
MCA_03669_1	87.335%	379	0.0	MCA_03669_1
A0A167CG06_9ASCO	79.947%	374	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Sugiyamaella lignohabitans GN=SFA1 PE=3 SV=1
A0A060TAZ6_BLAAD	79.947%	374	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11440g PE=3 SV=1
A0A1E3PPY8_9ASCO	76.455%	378	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45224 PE=3 SV=1
A0A1D8PU61_CANAL	77.600%	375	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FDH3 PE=3 SV=1
UniRef50_A0A179GY24	74.005%	377	0.0	Endonuclease III homolog n=1 Tax=Purpureocillium lilacinum TaxID=33203 RepID=A0A179GY24_9HYPO
A0A1E4TLY3_9ASCO	76.190%	378	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1331 PE=3 SV=1
Q6C297_YARLI	72.533%	375	0.0	S-(hydroxymethyl)glutathione dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09603g PE=3 SV=1
FADH_YEAST	68.435%	377	1.05e-174	S-(hydroxymethyl)glutathione dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SFA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0390

Protein family membership

Alcohol dehydrogenase class III (IPR014183)

Domains and repeats

Domain
4 - 189
GroES-like (IPR011032)
Alcohol dehydrogenase, N-terminal (IPR013154)
206 - 324
Alcohol dehydrogenase, C-terminal (IPR013149)
326 - 376
GroES-like (IPR011032)
Domain
168 - 342
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 377

Detailed signature matches

IPR014183

Alcohol dehydrogenase class III
1. cd08300 (alcohol_DH...)
  
  9 - 376
  
  CDD
  cd08300 (alcohol_DH_class_III)
2. TIGR02818
  
  11 - 377
  
  TIGRFAMs
  TIGR02818 (TIGR02818)
IPR011032

GroES-like
1. SSF50129 (GroES-like)
  
  326 - 376
  
  SUPERFAMILY
  SSF50129 (GroES-like)
  
  4 - 189
  
  SUPERFAMILY
  SSF50129 (GroES-like)
IPR013154

Alcohol dehydrogenase, N-terminal
1. PF08240 (ADH_N)
  
  36 - 161
  
  Pfam
  PF08240 (ADH_N)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  168 - 342
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR013149

Alcohol dehydrogenase, C-terminal
1. PF00107 (ADH_zinc_N)
  
  206 - 324
  
  Pfam
  PF00107 (ADH_zinc_N)
IPR002328

Alcohol dehydrogenase, zinc-type, conserved site
1. PS00059 (ADH_ZINC)
  
  69 - 83
  
  PROSITE patterns
  PS00059 (ADH_ZINC)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

205 - 319

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.18...

1 - 204

GENE3D
G3DSA:3.90.180.10 (G3DSA:3.90.180.10)

320 - 377

GENE3D
G3DSA:3.90.180.10 (G3DSA:3.90.180.10)

Residue annotation

catalytic Zn bindi...

48C

catalytic Zn binding site
48C, 70H, 71E, 177C
CDD
cd08300 (alcohol_DH_class_III)

70H

catalytic Zn binding site
48C, 70H, 71E, 177C
CDD
cd08300 (alcohol_DH_class_III)

71E

catalytic Zn binding site
48C, 70H, 71E, 177C
CDD
cd08300 (alcohol_DH_class_III)

177C

catalytic Zn binding site
48C, 70H, 71E, 177C
CDD
cd08300 (alcohol_DH_class_III)
substrate binding ...

48C

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

50T

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

59D

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

60P

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

61E

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

70H

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

96Y

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

97T

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

177C

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

297V

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)

321A

substrate binding site
48C, 50T, 59D, 60P, 61E, 70H, 96Y, 97T, 177C, 297V, 321A
CDD
cd08300 (alcohol_DH_class_III)
NAD binding site c...

49H

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

50T

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

177C

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

181T

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

202G

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

203A

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

204G

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

205C

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

206V

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

226D

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

227I

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

231K

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

271C

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

272T

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

276N

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

277V

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

295I

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

296G

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

320C

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

321A

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

322F

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)

372R

NAD binding site
49H, 50T, 177C, 181T, 202G, 203A, 204G, 205C, 206V, 226D, 227I, 231K, 271C, 272T, 276N, 277V, 295I, 296G, 320C, 321A, 322F, 372R
CDD
cd08300 (alcohol_DH_class_III)
structural Zn bind...

100C

structural Zn binding site
100C, 103C, 106C, 114C
CDD
cd08300 (alcohol_DH_class_III)

103C

structural Zn binding site
100C, 103C, 106C, 114C
CDD
cd08300 (alcohol_DH_class_III)

106C

structural Zn binding site
100C, 103C, 106C, 114C
CDD
cd08300 (alcohol_DH_class_III)

114C

structural Zn binding site
100C, 103C, 106C, 114C
CDD
cd08300 (alcohol_DH_class_III)
dimer interface cd...

104K

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

105F

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

108S

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

110K

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

111T

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

113L

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

115G

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

262D

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

267Y

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

278M

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

279R

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

286H

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

287K

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

288G

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

289W

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

298A

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

301G

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

302E

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

303V

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

304I

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

305Q

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

306T

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

307R

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

308P

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

311L

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

312V

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

313T

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

316V

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

317W

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

318K

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

319G

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

320C

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

321A

dimer interface
104K, 105F, 108S, 110K, 111T, 113L, 115G, 262D, 267Y, 278M, 279R, 286H, 287K, 288G, 289W, 298A, 301G, 302E, 303V, 304I, 305Q, 306T, 307R, 308P, 311L, 312V, 313T, 316V, 317W, 318K, 319G, 320C, 321A
CDD
cd08300 (alcohol_DH_class_III)

Protein sequence

>MIA_01564_1
MSDTEGKIITCKAAIAWEAGKPLTVEDVEVLPPRAHEVRIKIASTGVCHTDAYTLSGKDPEGAFPVILGHEGAGIVESVG
EGVTNVKKGDHVIALYTAECRKCKFCKSGKTNLCGAVRATQGKGVMPDGTSRFRARGQEILHFMGCSTFSEYTVVADVSI
VAVNETAPFDRICLLGCGITTGYGAATITANIQEGDNVAVFGAGCVGLSVVQGAAARKAGSIYVIDIDDKKEEWAKNFGA
THFINPTKVNRPIQEELVEVTDGGLDYTFDCTGNVNVMRSALEACHKGWGTSIIIGVAAAGEVIQTRPFQLVTGRVWKGC
AFGGVKGRTQLPGIVEDYLAGKIKVDQFITHRHDINGINQAFDDMHSGDCIRAVINY

GO term prediction

Biological Process

GO:0006069 ethanol oxidation
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features