Protein

MCA_03669_1

Length
379 amino acids

Browser: contigC:736725-737865-

RNA-seq: read pairs 10462, FPKM 340.2, percentile rank 92.6% (100% = highest expression)

Protein function

KEGG:K00121frmA S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
EGGNOG:0PFQFFLD1Dehydrogenase
SGD closest match:S000002327SFA1S-(hydroxymethyl)glutathione dehydrogenase
CGD closest match:CAL0000175789FDH3S-(hydroxymethyl)glutathione dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_01564_187.34%3790.0MIA_01564_1
A0A0J9X4U2_GEOCN83.24%3760.0S-(hydroxymethyl)glutathione dehydrogenase OS=Geotrichum candidum GN=BN980_GECA02s00736g PE=3 SV=1
A0A167CG06_9ASCO80.05%3760.0S-(hydroxymethyl)glutathione dehydrogenase OS=Sugiyamaella lignohabitans GN=SFA1 PE=3 SV=1
A0A060TAZ6_BLAAD78.99%3760.0S-(hydroxymethyl)glutathione dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11440g PE=3 SV=1
A0A1E4TLY3_9ASCO76.92%3770.0S-(hydroxymethyl)glutathione dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1331 PE=3 SV=1
A0A1D8PU61_CANAL76.33%3760.0S-(hydroxymethyl)glutathione dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FDH3 PE=3 SV=1
UniRef50_A0A1L9RHM173.28%3780.0Putative glutathione-dependent formaldehyde-activating enzyme n=1 Tax=Aspergillus wentii DTO 134E9 TaxID=1073089 RepID=A0A1L9RHM1_ASPWE
A0A1E3PPY8_9ASCO73.09%3790.0S-(hydroxymethyl)glutathione dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45224 PE=3 SV=1
Q6C297_YARLI71.28%3760.0S-(hydroxymethyl)glutathione dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09603g PE=3 SV=1
FADH_YEAST67.99%3781e-172S-(hydroxymethyl)glutathione dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SFA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0277

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 379

Detailed signature matches

  1. Family IPR014183
    Alcohol dehydrogenase class III
    1. cd08300 (alcohol_DH...)
    2. TIGR02818
  2. Domain IPR011032
    GroES-like
    1. SSF50129 (GroES-like)
  3. Domain IPR020843
    Polyketide synthase, enoylreductase domain
    1. SM00829 (PKS_ER_nam...)
  4. Domain IPR013154
    Alcohol dehydrogenase, N-terminal
    1. PF08240 (ADH_N)
  5. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  6. Domain IPR013149
    Alcohol dehydrogenase, C-terminal
    1. PF00107 (ADH_zinc_N)
  7. SITE IPR002328
    Alcohol dehydrogenase, zinc-type, conserved site
    1. PS00059 (ADH_ZINC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.18...

Residue annotation

  1. catalytic Zn bindi...
  2. substrate binding ...
  3. NAD binding site c...
  4. structural Zn bind...
  5. dimer interface cd...

Protein sequence

>MCA_03669_1
MSDTQGKTITCKAAIAWEAGKPLSVEEVEVLPPRAHEVRIKVVATGVCHTDAYTLSGKDPEGAFPVILGHEGAGIVESVG
EGVTNVKVGDHVIALYTAECKECKFCTSGKTNLCSKVRATQGQGVMPDGTSRFKAKKNGQELLHFMGCSTFSEYTVVADV
SVVAVNEKAEFDKICLLGCGITTGYGAATIVANVQEGDKVAIFGAGCVGLSVVQGAAQRKAAEIYVIDIDDKKKEWATKF
GATHFVNPTKVDRPIQEELVDRTDGGFDYTFDCTGNVKVMRSALECCHKGWGQSIIIGVAAAGEVIETRPFQLVTGRVWR
GCAFGGVKGRTQLPGIVEDYLAGKIKVEEFITHTHDINGINQAFDDMHSGNCIRAVIKY

GO term prediction

Biological Process

GO:0006069 ethanol oxidation
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity

Cellular Component

None predicted.