Protein

MIA_01552_1

Length
468 amino acids

Browser: contig02:1057941-1059348+

Protein function

EGGNOG:0PINTFG07381.1Pyruvate dehydrogenase kinase
SGD closest match:S000003027PKP2[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MCA_05321_166.461%4860.0MCA_05321_1
A0A0J9XHB7_GEOCN65.293%4610.0Similar to Saccharomyces cerevisiae YGL059W PKP2 Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex OS=Geotrichum candidum GN=BN980_GECA16s02386g PE=4 SV=1
A0A167F269_9ASCO61.024%4493.13e-179Protein kinase PKP2 OS=Sugiyamaella lignohabitans GN=PKP2 PE=4 SV=1
UniRef50_A0A167F26961.024%4498.59e-176Protein kinase PKP2 n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A167F269_9ASCO
A0A060T2H5_BLAAD57.110%4367.53e-165ARAD1C25344p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25344g PE=4 SV=1
Q6C089_YARLI53.167%4427.97e-147YALI0F26807p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26807g PE=4 SV=1
A0A1E4TC23_9ASCO50.234%4287.07e-129Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_11370 PE=4 SV=1
A0A1E3PKP9_9ASCO54.108%3532.45e-119Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46557 PE=4 SV=1
PDK2_YEAST35.928%5011.47e-81[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP2 PE=1 SV=3
A0A1D8PTU9_CANAL25.641%3511.57e-18Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5182
Predicted cleavage: 20

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 468

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00075 (HATPase_c)
  2. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MIA_01552_1
MLRAAIKHRPPPQPKFIRSWSDFAHHAEPGSLGSQLVSYTYPRGSTLINSRHFYQNTVLMEWVQRAPRPVSLRQLAFFGR
RLTRDKLLASANFVQQELPTRLAHRIRDMQVLPFGAVSNPHLCSVYEMYYSAFDQFRRFPKINTLEDNERFCSLLNKLLN
DHLTVIPKLVMGAIECSLANSIDSLRLDTFMSSILRSRISRRVIAEQHLALSSAFTTPAANTNHADDPSYIGAVFLQCSA
KEAVKSCGSRASELIQDLYPDSLMPEIIIEGSEDARFPYMQSHLDYILGELLRNSIEATVKKHEGESSPPPIVVSISNTH
ESVLIRVSDQGGGIAPDVLPYIWSFSKGPHMEHRLDNFKQVPTFAGLLQEVATEEEQLEQKLSHHHGKSSPLHPLSDKER
EEMMASLSSLMSRPPHLKLGMGLPLSKVYVEYWDGHIDLHSLEGYGCDVFLRISRLGNQSERLQLDRV

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.