Protein

MCA_05321_1

Length
519 amino acids

Gene name: PKP1D

Description: [Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial

Browser: contigD:1007778-1009401+

RNA-seq: read pairs 1229, FPKM 29.2, percentile rank 52.0% (100% = highest expression)

Protein function

Annotation:PKP1D[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
EGGNOG:0PINTFG07381.1Pyruvate dehydrogenase kinase
SGD closest match:S000003027PKP2[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MIA_01552_166.67%4860.0MIA_01552_1
A0A0J9XHB7_GEOCN61.46%5190.0Similar to Saccharomyces cerevisiae YGL059W PKP2 Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex OS=Geotrichum candidum GN=BN980_GECA16s02386g PE=4 SV=1
A0A167F269_9ASCO58.37%4782e-175Protein kinase PKP2 OS=Sugiyamaella lignohabitans GN=PKP2 PE=4 SV=1
UniRef50_A0A167F26958.37%4786e-172Protein kinase PKP2 n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A167F269_9ASCO
A0A060T2H5_BLAAD55.34%4682e-169ARAD1C25344p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25344g PE=4 SV=1
Q6C089_YARLI50.74%4734e-148YALI0F26807p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26807g PE=4 SV=1
A0A1E3PKP9_9ASCO55.10%3632e-129Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46557 PE=4 SV=1
A0A1E4TC23_9ASCO44.18%4649e-118Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_11370 PE=4 SV=1
PDK2_YEAST34.90%4901e-77[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP2 PE=1 SV=3
A0A1D8PTU9_CANAL28.78%1391e-10Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9744
Predicted cleavage: 105

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 519

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. cd00075 (HATPase_c)
  7. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MCA_05321_1
MISKINRTKLSKVSALLLQSTPALSQRFAHTQSSRNGFAHHAEPGSLSSQLVSYTYPPNSNLINSRHFYQNSVLMDWVKI
APRPVSLRQLAFFGRHLTAEKLISSANFVQHELPTRIAHRIRDMQVLPFAFVSNYHMCKVYEMYYEAFDKFRRFPKIKTL
EENDQFCLLLNKLLTDHLAVIPQLVMGAIESSMAGTLDSERLDDFMSSILRSRISRRVIAEQHLALTKNFKNGTHNKKPA
HSHHNQQDDSINSIGAVFLQCSAMDSVRASGVRASHLIQELYPDAVMPEVIIEGLEDAKFPYMKSHLDYILGELLRNSIE
ATVSQHYSSQNSSDAPPPPVVVSISSTHESVLIRISDQGGGVPADVLPYVWSFAKGPRSQYRLENFKQVPTLAGIVQEVV
TQEEQESNGTTNGNHSKQDSHNNNHHHHQKKSHKHKRKQMTLQESLNHINKNHTMSSLTSLTSRPPQLKLGMGLPLSKIY
VEYWDGHIDLHSLEGYGCDVYLRISRLGNQSEKLQLDRV

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.