Protein

MIA_01540_1

Length
522 amino acids

Browser: contig02:1021538-1023107+

Protein function

EGGNOG:0PHHYERG1squalene
SGD closest match:S000003407ERG1Squalene monooxygenase
CGD closest match:CAL0000179458ERG1Squalene monooxygenase

Protein alignments

%idAln lengthE-value
MCA_02475_163.098%5230.0MCA_02475_1
A0A0J9XB44_GEOCN51.874%5073.56e-172Similar to Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase OS=Geotrichum candidum GN=BN980_GECA08s00169g PE=4 SV=1
A0A1E3PSS0_9ASCO49.219%5122.42e-165SE-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81361 PE=4 SV=1
Q6C5R8_YARLI47.421%5042.56e-150YALI0E15730p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E15730g PE=4 SV=1
UniRef50_Q6C5R847.421%5045.93e-147YALI0E15730p n=2 Tax=Yarrowia lipolytica TaxID=4952 RepID=Q6C5R8_YARLI
A0A060T4Q4_BLAAD46.926%4881.08e-149ARAD1B01342p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B01342g PE=4 SV=1
ERG1_CANAL40.232%5173.87e-122Squalene monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG1 PE=3 SV=1
ERG1_YEAST40.509%5111.45e-121Squalene monooxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG1 PE=1 SV=2
A0A1E4TDG6_9ASCO40.079%5092.41e-102Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144303 PE=4 SV=1
A0A167DWK5_9ASCO58.371%2211.71e-84Squalene monooxygenase OS=Sugiyamaella lignohabitans GN=ERG1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1327
Predicted cleavage: 43

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 522

Detailed signature matches

  1. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. G3DSA:3.50.50.60
    2. SSF51905 (FAD/NAD(P...)
  2. Domain IPR013698
    Squalene epoxidase
    1. PF08491 (SE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. PR00420 (RNGMNOXGNASE)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)

Protein sequence

>MIA_01540_1
MTTSSSPPSPPPGGAAVYDMIIVGAGVVGPALAHAMALQGRRVALIERDLREPNRIVGELLQPAGLHALERLGLADCVEG
IDAIPEIGYTIFYEGQSVKLPYPPRGYPEMRQGSAPAATKEPEAEASLEQIIKVRENGVSFHHGRFIMKLREAAAKHKDY
VDVIEATVTATILEEEEVEPPELLAKKRVHRTLGRVVGVRIKQAIDGDKAAGFVERTLFAPITVIADGTTSKFRKEYTTR
TPVVKSHFVGVVLENAELVAPNHGHVLLGTKFAPVLVYQIGGSETRALFDIQGAMPSIANGDMAAHLTEKVVPYLPGQLQ
PSMRAAIAKGQFRSMPNQFLPTSPQRTPGVIVLGDAWNMRHPLTGGGMTVALNDVDLLRTLLRDHASTLDWSDWAAVQAQ
VLEPFYWRRKNLGAVVNILAQALYALFAANSEDLYVLQRGCFRYFERGGTCVSDPVSLLSGILPRPLVLFHHFFAVAFYA
IYCNFCDAGLAGFPAALIRSFTVLYTATIVILPYILEELKWY

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004506 squalene monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

GO:0016021 integral component of membrane