Protein

MCA_02475_1

Length
512 amino acids

Gene name: ERG1

Description: Squalene monooxygenase

Browser: contigB:1414957-1416496-

RNA-seq: read pairs 4435, FPKM 106.8, percentile rank 79.9% (100% = highest expression)

Protein function

Annotation:ERG1Squalene monooxygenase
KEGG:K00511SQLE squalene monooxygenase [EC:1.14.14.17]
EGGNOG:0PHHYERG1squalene
SGD closest match:S000003407ERG1Squalene monooxygenase
CGD closest match:CAL0000179458ERG1Squalene monooxygenase

Protein alignments

%idAln lengthE-value
MIA_01540_163.67%5230.0MIA_01540_1
A0A0J9XB44_GEOCN57.23%5050.0Similar to Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase OS=Geotrichum candidum GN=BN980_GECA08s00169g PE=4 SV=1
A0A1E3PSS0_9ASCO53.91%4990.0SE-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81361 PE=4 SV=1
Q6C5R8_YARLI48.92%5091e-158YALI0E15730p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E15730g PE=4 SV=1
UniRef50_Q6C5R848.92%5092e-155YALI0E15730p n=2 Tax=Yarrowia lipolytica TaxID=4952 RepID=Q6C5R8_YARLI
A0A060T4Q4_BLAAD47.52%4843e-151ARAD1B01342p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B01342g PE=4 SV=1
ERG1_YEAST42.19%5121e-135Squalene monooxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG1 PE=1 SV=2
ERG1_CANAL43.50%5155e-135Squalene monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG1 PE=3 SV=1
A0A1E4TDG6_9ASCO42.39%4936e-114Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144303 PE=4 SV=1
A0A167DWK5_9ASCO59.09%2202e-83Squalene monooxygenase OS=Sugiyamaella lignohabitans GN=ERG1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0177

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 512

Detailed signature matches

  1. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. G3DSA:3.50.50.60
    2. SSF51905 (FAD/NAD(P...)
  2. Domain IPR013698
    Squalene epoxidase
    1. PF08491 (SE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. PR00420 (RNGMNOXGNASE)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)

Protein sequence

>MCA_02475_1
MTVEAHIPSSSSNNDAFYDVVIVGAGIVGPSMAVALSKQNRRVALIERDLSEPNRIVGELMQPSGIHSLEKLGLESCVEG
IEAIPAIGYQIFYQGESINLPYPDLETPKSTPISPEEPAAKISDICRVRETGRSFHHGRFIMNLRKAAMACKPNVDVIEA
TVTTILTEDQELEPREVLEAKQKRIPHRIVGVSIKETKTVGDVKETTTRNIFAPLTIVADGTTSKFRKGLTSRTPKVKSH
FVGLILEDADIPKPYHGHVILGTKFAPVLVYQIDPHETRALFDIQGPNLPSVANGDMKTHLLDNVLPNLPEQLQPSVKKA
ILKGQFRSMPNQFLPTSPQRIPGVIVLGDAWNMRHPLTGGGMTVALNDVVLLSERLGLVGTFDRWDDIEDQLDRFYWERK
KLGSVVNILAQALYSLFAAKSDNLIILQKGCFEYFQRGGKCVEEPISLLSGILPRPVVLVRHFFAVAFYAIYCNYLDKGL
KGFPLAFIQSFTVLYTATVVILPYIIEEIKWY

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004506 squalene monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

GO:0016021 integral component of membrane