Protein

MIA_01534_1

Length
392 amino acids

Browser: contig02:1005123-1006302+

Protein function

EGGNOG:0PG2BMVD1diphosphomevalonate decarboxylase
SGD closest match:S000005326MVD1Diphosphomevalonate decarboxylase
CGD closest match:CAL0000181620MVDDiphosphomevalonate decarboxylase

Protein alignments

%idAln lengthE-value
MCA_01009_171.654%3810.0MCA_01009_1
A0A0J9XBT1_GEOCN68.878%3920.0Diphosphomevalonate decarboxylase OS=Geotrichum candidum GN=BN980_GECA08s02342g PE=3 SV=1
A0A1E3PQY6_9ASCO64.450%3911.79e-170Diphosphomevalonate decarboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44460 PE=3 SV=1
A0A167F945_9ASCO63.683%3912.18e-165Diphosphomevalonate decarboxylase OS=Sugiyamaella lignohabitans GN=MVD1 PE=3 SV=1
Q6C2S1_YARLI61.954%3891.40e-159Diphosphomevalonate decarboxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F05632g PE=3 SV=1
UniRef50_Q6C2S161.954%3893.24e-156Diphosphomevalonate decarboxylase n=10 Tax=Eukaryota TaxID=2759 RepID=Q6C2S1_YARLI
A0A060TE79_BLAAD61.499%3879.95e-156Diphosphomevalonate decarboxylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D49698g PE=3 SV=1
A0A1E4T9M5_9ASCO61.053%3809.15e-154Diphosphomevalonate decarboxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148708 PE=3 SV=1
A0A1D8PC43_CANAL60.526%3801.32e-139Diphosphomevalonate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MVD PE=3 SV=1
MVD1_YEAST57.035%3988.77e-138Diphosphomevalonate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MVD1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1811
Predicted cleavage: 26

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 392

Detailed signature matches

  1. Family IPR005935
    Diphosphomevalonate/phosphomevalonate decarboxylase
    1. PIRSF015950 (Mev_P_...)
  2. Family IPR029765
    Diphosphomevalonate decarboxylase
    1. TIGR01240
  3. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  4. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  5. Domain IPR006204
    GHMP kinase N-terminal domain
    1. PF00288 (GHMP_kinas...)
  6. Domain IPR013750
    GHMP kinase, C-terminal domain
    1. SSF55060 (GHMP Kina...)
    2. G3DSA:3.30.70...
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil

Protein sequence

>MIA_01534_1
MAEIYSYTSTAPVNIATLKYWGKRNVSLNLPTNSSVSVTLDQSDLRAITTAATSSSFTKDRLWLNGTEEEIEKSARLSTC
VRELRKLRIEYEEKLAAEKKEVVPLSTYKLHIVSENNFPTAAGLASSAAGFAALVSSVAGLYELPQTPEELSVLARQGSG
SACRSLFGGYVAWDMGTKEDGSDSKAESVASREHWPEMRALILVANANKKDVSSTSGMQTTVATSSLFKERIETVVPERY
EAMKKAIVDKDFESFAELTMRDSNQFHAVCLDSYPPIFYLNDTSRAAIRTVEEINKHAGKTVAAYTFDAGPNCVVYFLEE
NAEKVIGPIRSALATAEGWNATEIAASLPEGFEKRWLEVLSTGVSRVYLTKVGDGPKKSNETLIGANGEPKN

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway

Molecular Function

GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016831 carboxy-lyase activity

Cellular Component

GO:0005829 cytosol