Protein

MCA_01009_1

Length
386 amino acids

Gene name: MVD1

Description: Diphosphomevalonate decarboxylase

Browser: contigA:3209447-3210608-

RNA-seq: read pairs 2534, FPKM 80.9, percentile rank 75.5% (100% = highest expression)

Protein function

Annotation:MVD1Diphosphomevalonate decarboxylase
KEGG:K01597MVD diphosphomevalonate decarboxylase [EC:4.1.1.33]
EGGNOG:0PG2BMVD1diphosphomevalonate decarboxylase
SGD closest match:S000005326MVD1Diphosphomevalonate decarboxylase
CGD closest match:CAL0000181620MVDDiphosphomevalonate decarboxylase

Protein alignments

%idAln lengthE-value
MIA_01534_171.92%3810.0MIA_01534_1
A0A0J9XBT1_GEOCN67.88%3861e-175Diphosphomevalonate decarboxylase OS=Geotrichum candidum GN=BN980_GECA08s02342g PE=3 SV=1
A0A1E3PQY6_9ASCO67.39%3712e-167Diphosphomevalonate decarboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44460 PE=3 SV=1
A0A167F945_9ASCO65.96%3791e-164Diphosphomevalonate decarboxylase OS=Sugiyamaella lignohabitans GN=MVD1 PE=3 SV=1
Q6C2S1_YARLI65.49%3685e-161Diphosphomevalonate decarboxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F05632g PE=3 SV=1
UniRef50_Q6C2S165.49%3681e-157Diphosphomevalonate decarboxylase n=10 Tax=Eukaryota TaxID=2759 RepID=Q6C2S1_YARLI
A0A1E4T9M5_9ASCO62.77%3763e-153Diphosphomevalonate decarboxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148708 PE=3 SV=1
A0A060TE79_BLAAD61.39%3731e-151Diphosphomevalonate decarboxylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D49698g PE=3 SV=1
A0A1D8PC43_CANAL62.19%3651e-140Diphosphomevalonate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MVD PE=3 SV=1
MVD1_YEAST58.58%3796e-136Diphosphomevalonate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MVD1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0986
Predicted cleavage: 56

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 386

Detailed signature matches

  1. Family IPR005935
    Diphosphomevalonate/phosphomevalonate decarboxylase
    1. PIRSF015950 (Mev_P_...)
  2. Family IPR029765
    Diphosphomevalonate decarboxylase
    1. TIGR01240
  3. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  4. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  5. Domain IPR006204
    GHMP kinase N-terminal domain
    1. PF00288 (GHMP_kinas...)
  6. Domain IPR013750
    GHMP kinase, C-terminal domain
    1. SSF55060 (GHMP Kina...)
    2. G3DSA:3.30.70...

Protein sequence

>MCA_01009_1
MSDIKSYCAIAPVNIATLKYWGKRDVGLNLPTNSSISVTLDPNYLRALTTATTSPSYTEDRLWLNGTEESITSSKRLSTC
LAELRKLRKAKEESDKSADPSLSSWKVHIISENNFPTAAGLASSAAGFAAFVKAIAGLFELDTSAEDLSIIARQGSGSAC
RSLFGGYVAWEMGQKEDGSDSKAVCIAPKEHWPEMRAAILVANANKKDVSSTSGMQSTVATSSLFKERIGTVVPQRFEEM
KKSILEKDFETFAELTMKDSNQFHAVCLDSYPPIFYMNDTSQAAIRTVEEINKNAGHTVAAYTFDAGPNCVIYFLEENAA
QVLGPLKKVLGEREGWENYANVSSEISESFDTKWLERLATGVSRVYITKVGEGAQGSDIRLEEPTA

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway

Molecular Function

GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016831 carboxy-lyase activity

Cellular Component

GO:0005829 cytosol