Protein

MIA_01476_1

Length
499 amino acids

Browser: contig02:831912-833412-

Protein function

EGGNOG:0PGPMTRP1anthranilate synthase
SGD closest match:S000001694TRP3Multifunctional tryptophan biosynthesis protein
CGD closest match:CAL0000192837TRP3Bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase

Protein alignments

%idAln lengthE-value
MCA_03891_180.122%4930.0MCA_03891_1
A0A0J9X7T3_GEOCN75.758%4950.0Similar to Saccharomyces cerevisiae YKL211C TRP3 Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities OS=Geotrichum candidum GN=BN980_GECA04s06434g PE=4 SV=1
A0A1E3PHT0_9ASCO67.068%4980.0IGPS-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52140 PE=3 SV=1
A0A170QZP3_9ASCO67.600%5000.0Bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase OS=Sugiyamaella lignohabitans GN=TRP3 PE=3 SV=1
Q6C9H7_YARLI64.040%4950.0YALI0D11110p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D11110g PE=4 SV=1
A0A060TB89_BLAAD61.866%4930.0ARAD1D33264p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D33264g PE=4 SV=1
TRPG_YEAST62.351%5020.0Multifunctional tryptophan biosynthesis protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP3 PE=1 SV=2
UniRef50_P0093762.351%5020.0Multifunctional tryptophan biosynthesis protein n=38 Tax=Saccharomycetales TaxID=4892 RepID=TRPG_YEAST
A0A1E4TFJ6_9ASCO58.449%5030.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_106605 PE=3 SV=1
A0A1D8PFC8_CANAL56.226%5140.0Bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TRP3 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0165

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 499

Detailed signature matches

  1. Domain IPR029062
    Class I glutamine amidotransferase-like
    1. G3DSA:3.40.50...
    2. SSF52317 (Class I g...)
  2. Domain IPR017926
    Glutamine amidotransferase
    1. PF00117 (GATase)
    2. PS51273 (GATASE_TYPE_1)
  3. Domain IPR006221
    Anthranilate synthase/para-aminobenzoate synthase like domain
    1. TIGR00566
  4. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  5. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)
  6. Domain IPR013798
    Indole-3-glycerol phosphate synthase
    1. MF_00134_B (IGPS_B)
    2. cd00331 (IGPS)
    3. PF00218 (IGPS)
  7. SITE IPR001468
    Indole-3-glycerol phosphate synthase, conserved site
    1. PS00614 (IGPS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PR00096 (GATASE)
  2. PR00097 (ANTSNTHASEII)
  3. PR00099 (CPSGATASE)
  4. cd01743 (GATase1_An...)

Residue annotation

  1. glutamine binding ...
  2. catalytic triad cd...
  3. ribulose/triose bi...
  4. active site cd00331
  5. phosphate binding ...
  6. substrate (anthran...
  7. product (indole) b...

Protein sequence

>MIA_01476_1
MTATKPNVLMIDNYDSFTWNLYEYLCQEGAEVQVYRNDKITIPEIEALNPDRIVISPGPGHPLHDSGISRQCIEHFAGKI
PVIGVCMGQQCIYSVFGGSVEYAGEIVHGKTSTVKHDAKGIFDGVSQDISVTRYHSLAGTQPTLPDDLEVTARTDSGVIM
GVRHKKYTVEGVQFHPESILTEEGHLMVRNFLNIQGGTWESDTEFKKKNNTFTSSTSATSGLSSTLSSTKSKSILDQIFD
QRKKDVEQLKSTPGKSFEDLKKSYALGLAPPQIKDVVARLKQSTPALMAEIKRASPSKGPINLQAHAASYAITYAKAGAS
AISILTEPHWFKGDINDLREVRKVIDSVPNRPVVLRKEFIFDEYQILEARLAGADTVLLIVKMLDDTLLRRLYDYSVSLG
MEPLVEVNSAPEMKRALAIGSKLIGVNNRDLHSFSVDLNTTSSLVSLVPEGTVLAALSGISGNADVRKYYEEGVSAVLVG
EALMKASDTQAFIKELLSV

GO term prediction

Biological Process

GO:0006568 tryptophan metabolic process
GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004425 indole-3-glycerol-phosphate synthase activity

Cellular Component

None predicted.