MIA_01386_1

Protein

Length

1,801 amino acids

Protein function

EGGNOG:	0PNNN	IRS4	Positive regulator of phosphatidylinositol 4,5- bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity)
SGD closest match:	S000001727	IRS4	Increased rDNA silencing protein 4
CGD closest match:	CAL0000177117	IRS4	Increased rDNA silencing protein 4

Protein alignments

	%id	Aln length	E-value
MCA_00619_1	75.281%	89	1.63e-40	MCA_00619_1
A0A167F4T9_9ASCO	71.429%	84	5.35e-38	Irs4p OS=Sugiyamaella lignohabitans GN=IRS4 PE=4 SV=1
UniRef50_A0A167F4T9	71.429%	84	1.47e-34	Irs4p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167F4T9_9ASCO
A0A0J9XAQ5_GEOCN	72.619%	84	2.29e-36	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA07s01913g PE=4 SV=1
IRS4_YARLI	67.073%	82	8.49e-33	Increased rDNA silencing protein 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=IRS4 PE=3 SV=1
A0A060TGA8_BLAAD	60.227%	88	5.43e-32	ARAD1D28644p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D28644g PE=4 SV=1
A0A1E3PME2_9ASCO	71.429%	77	3.22e-34	EF-hand protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_7947 PE=4 SV=1
IRS4_CANAL	54.545%	77	6.88e-25	Increased rDNA silencing protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IRS4 PE=3 SV=2
IRS4_YEAST	58.571%	70	7.61e-23	Increased rDNA silencing protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRS4 PE=1 SV=1
A0A1E4TAQ7_9ASCO	59.420%	69	6.98e-25	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15995 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8209
Predicted cleavage: 128

Protein family membership

None predicted.

Domains and repeats

Domain
553 - 1,137
WD40/YVTN repeat-like-containing domain (IPR015943)
1,156 - 1,487
WD40/YVTN repeat-like-containing domain (IPR015943)
1,596 - 1,685
EF-hand domain pair (IPR011992)
EH domain (IPR000261)

1 200 400 600 800 1000 1200 1400 1600 1801

Detailed signature matches

IPR015943

WD40/YVTN repeat-like-containing domain
1. G3DSA:2.130.1...
  
  553 - 1,137
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
  
  1,156 - 1,487
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
IPR011992

EF-hand domain pair
1. SSF47473 (EF-hand)
  
  1,609 - 1,684
  
  SUPERFAMILY
  SSF47473 (EF-hand)
IPR000261

EH domain
1. SM00027 (eh_3)
  
  1,601 - 1,684
  
  SMART
  SM00027 (eh_3)
2. PF12763 (EF-hand_4)
  
  1,615 - 1,667
  
  Pfam
  PF12763 (EF-hand_4)
3. PS50031 (EH)
  
  1,596 - 1,685
  
  PROSITE profiles
  PS50031 (EH)

no IPR

Unintegrated signatures

Coil

1,219 - 1,253

COILS
Coil (Coil)

1,170 - 1,190

COILS
Coil (Coil)

558 - 602

COILS
Coil (Coil)

1,766 - 1,799

COILS
Coil (Coil)

616 - 636

COILS
Coil (Coil)

1,689 - 1,713

COILS
Coil (Coil)

131 - 151

COILS
Coil (Coil)

1,525 - 1,552

COILS
Coil (Coil)
G3DSA:1.10.23...

1,490 - 1,691

GENE3D
G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
cd00052 (EH)

1,610 - 1,666

CDD
cd00052 (EH)
mobidb-lite (disord...)

1,749 - 1,801

MobiDB Lite
mobidb-lite (disorder_prediction)

888 - 927

MobiDB Lite
mobidb-lite (disorder_prediction)

743 - 839

MobiDB Lite
mobidb-lite (disorder_prediction)

1,695 - 1,719

MobiDB Lite
mobidb-lite (disorder_prediction)

1,021 - 1,040

MobiDB Lite
mobidb-lite (disorder_prediction)

183 - 301

MobiDB Lite
mobidb-lite (disorder_prediction)

377 - 410

MobiDB Lite
mobidb-lite (disorder_prediction)

952 - 973

MobiDB Lite
mobidb-lite (disorder_prediction)

99 - 156

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 44

MobiDB Lite
mobidb-lite (disorder_prediction)

1,406 - 1,425

MobiDB Lite
mobidb-lite (disorder_prediction)

700 - 720

MobiDB Lite
mobidb-lite (disorder_prediction)

484 - 544

MobiDB Lite
mobidb-lite (disorder_prediction)

1,168 - 1,297

MobiDB Lite
mobidb-lite (disorder_prediction)

672 - 691

MobiDB Lite
mobidb-lite (disorder_prediction)

1,358 - 1,377

MobiDB Lite
mobidb-lite (disorder_prediction)

1,465 - 1,607

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

pseudo EF-hand loo...

1,610D

pseudo EF-hand loop
1,610D, 1,615I, 1,616H, 1,617G, 1,618F, 1,619I
CDD
cd00052 (EH)

1,615I

pseudo EF-hand loop
1,610D, 1,615I, 1,616H, 1,617G, 1,618F, 1,619I
CDD
cd00052 (EH)

1,616H

pseudo EF-hand loop
1,610D, 1,615I, 1,616H, 1,617G, 1,618F, 1,619I
CDD
cd00052 (EH)

1,617G

pseudo EF-hand loop
1,610D, 1,615I, 1,616H, 1,617G, 1,618F, 1,619I
CDD
cd00052 (EH)

1,618F

pseudo EF-hand loop
1,610D, 1,615I, 1,616H, 1,617G, 1,618F, 1,619I
CDD
cd00052 (EH)

1,619I

pseudo EF-hand loop
1,610D, 1,615I, 1,616H, 1,617G, 1,618F, 1,619I
CDD
cd00052 (EH)
peptide binding po...

1,624W

peptide binding pocket
1,624W, 1,634L, 1,638W
CDD
cd00052 (EH)

1,634L

peptide binding pocket
1,624W, 1,634L, 1,638W
CDD
cd00052 (EH)

1,638W

peptide binding pocket
1,624W, 1,634L, 1,638W
CDD
cd00052 (EH)
Ca2+ binding site ...

1,642D

Ca2+ binding site
1,642D, 1,644N, 1,646D, 1,653G
CDD
cd00052 (EH)

1,644N

Ca2+ binding site
1,642D, 1,644N, 1,646D, 1,653G
CDD
cd00052 (EH)

1,646D

Ca2+ binding site
1,642D, 1,644N, 1,646D, 1,653G
CDD
cd00052 (EH)

1,653G

Ca2+ binding site
1,642D, 1,644N, 1,646D, 1,653G
CDD
cd00052 (EH)

Protein sequence

>MIA_01386_1
MPTLDVSSSKTQRAPGSATSPVPSVHSNHVARPSSGQGVSAAAAASASASAAAAATINCITNNTLGSLHPVPSTTSLGSS
NIISTASASSKRITSSSIAPFVSSPPLQPTLLQQSHPPNHPTPVLRQQGPNKSRKKQKEEYRKQYRTAQQNEQNAVLSTS
AMTASAAAAASAKKSSLSVGVGVGNGGNNSNSSSNGSGAANSSNNRHSQPAHTTNESIQVVHSTSSKRTPSATRPRIEPV
QKKSTQTQSQQPRSTSSTSTSVTTTKSSNQHLEVPTNPIVIPTSPISSSSSPSTMNSPLLASPSSGNHLFFRPDNTPSSA
ASASAAAAFKKLPVASVSSPASSISSAISSTSLATSPSAGSKHLAYYFSDTHEHAQRATSPSAASEYSVYTLQQQHSTNS
SEDPLSTHAASSSLLTNAARAARQPSPVVMLKEHDAASSLAAAKLSVTTTPKEISALESLIHENNQLPPKQRLVAHAAAK
ALPITETESDASATTTTSSASEESTEEATLQQAAARSAQMGPPSPLLQASGAAAASGGETGSIAAPEDNAIKRTAMQAAS
LATQKQQQEAQAKEQLREQQLQQEKLERLEKLEKQEKQQQIQQQIQLQIQHEKHQQQLLEQNQAKYISKVANLQKQQQQQ
QRAAMSSSTTAARPISTASTAAILAAANPLEVPPAKEHSPSPGLSPSITPNLETESVLGVPTSVSTATSPPQASDGAVLY
SPTPIKGGALNHIPLLQSHGRTLGVTHTNKNSTSGNSNSANLKAPSLPKRPLSAQSVDSVSSSWIDPSAADHQPHTSAAT
HASAHAPIAVSKPKTKKPMPNPGVHHSQTLPVPSSNQHHLPTVTRAATSVTIPQKSSRPLSYHVGLGYMPGSAPAPVAPS
HIGFKTTTLRQHRKTKSSSSSAQHFALRSSATLPPLPSPSSSSSAAAAFPDFEKPTAPHAIHYNFPSASSSPLTTSSSAA
TSGSSLHATSGTDTATNMRGLVKAATIFAYNNGTHTASANPSNSSGSASSRILSLATYPHSQMSHFNPQSPSTSSLTSTS
SSANVVVPSLRSSRGNHGILSLVKRKLIPGESSSNSSNNSGVCANSGVSVSGTGVNGGPLKADEVGLNLSRVKTTMRKQS
RRKSFNEDKPWKHHIDAMTLTDSEKRRYEGLWASNRGKHLKYIYHPEDYEEEDEEEQKEREDKNKEIKKKTVLEQSTKPV
EDSEDDYEEEEEDSELSASSDEESDLEDEDDDEEEEEEEEEEEDDDEEDEEEASDMASMTSGYDEDIEDEDEEEEEKSKS
QVHHPHPVVKLHVEDVPLRRTSAPEIMTRAASAPSAASALSMHTVASSASSQYLTACTSPALSINEPGNEVELRRHSASA
SVPSRRSSDNIPGTTIIPRAHTASPTLQQNTKTTSMATVLALQATAGSAHSSRSPSPSMLSARGIARASSPSPIYIQSVN
NSRGASPSVLDVPFESLTRAARFPGGVTTTSSSPGSGGSLATALARPGAKRASSSHSIERLKNTFRSMSPPKMRRRNAEE
EWGQRQEEERALREMKQQMEKQQQLRQQQLAEREKASNPKPVKTEPLDQKSTPPLVATSGPTTTAASTTTAVVRAPRPKS
PPKVYRIERDPKDDIHGFIVRNLWRRSRLPDTTLAQIWDLVDRNHDGTLDREGFLVGTWLVDQCLYGRKLPHRIDDALWR
SVSRLGVRVEILKKKQRRQRERQQRHEQQLKRNSQNHRVKTLHGPTIAGHHVVPHKPHKHHKHDNVTAAEGEVGGGAGDK
QAKRALKKQQKLDDKQRKEQRKLEKKQRKELEKERLRELEK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_01386_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component