Protein
MCA_00619_1
Length
1,394 amino acids
Gene name: IRS4
Description: Increased rDNA silencing protein 4
Browser: contigA:1896887-1901072+
RNA-seq: read pairs 1405, FPKM 12.4, percentile rank 29.9% (100% = highest expression)
Protein function
| Annotation: | IRS4 | Increased rDNA silencing protein 4 | |
|---|---|---|---|
| EGGNOG: | 0PNNN | IRS4 | Positive regulator of phosphatidylinositol 4,5- bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity) |
| SGD closest match: | S000001727 | IRS4 | Increased rDNA silencing protein 4 |
| CGD closest match: | CAL0000177117 | IRS4 | Increased rDNA silencing protein 4 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01386_1 | 75.00% | 88 | 4e-40 | MIA_01386_1 |
| A0A167F4T9_9ASCO | 70.37% | 81 | 5e-35 | Irs4p OS=Sugiyamaella lignohabitans GN=IRS4 PE=4 SV=1 |
| UniRef50_A0A167F4T9 | 70.37% | 81 | 1e-31 | Irs4p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167F4T9_9ASCO |
| A0A0J9XAQ5_GEOCN | 70.00% | 80 | 3e-33 | Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA07s01913g PE=4 SV=1 |
| IRS4_YARLI | 70.00% | 80 | 3e-32 | Increased rDNA silencing protein 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=IRS4 PE=3 SV=1 |
| A0A1E3PME2_9ASCO | 74.67% | 75 | 8e-34 | EF-hand protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_7947 PE=4 SV=1 |
| A0A060TGA8_BLAAD | 64.20% | 81 | 4e-29 | ARAD1D28644p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D28644g PE=4 SV=1 |
| IRS4_CANAL | 53.33% | 75 | 5e-22 | Increased rDNA silencing protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IRS4 PE=3 SV=2 |
| A0A1E4TAQ7_9ASCO | 58.21% | 67 | 8e-24 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15995 PE=4 SV=1 |
| IRS4_YEAST | 58.57% | 70 | 6e-21 | Increased rDNA silencing protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRS4 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0152
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1200
1394
Detailed signature matches
-
-
SSF47473 (EF-hand)
-
no IPR
Unintegrated signatures
-
-
-
cd00052 (EH)
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mobidb-lite (disord...)
Residue annotation
-
pseudo EF-hand loo...
-
peptide binding po...
-
Ca2+ binding site ...
Protein sequence
>MCA_00619_1 MPVAQVSQSNLSDASSFSPDTNISPSKQIINVISSSSTQHSPRSMPQNTDEIDSMKPSLSSSELISIPHSGSPSTSLNAD NVIYKSPTLPAVPIGPKQLGPNKSKKKQTEEFRLQYRTAQRNEQDQIVSNSILTAAAAAVASTKRKTNSSFSSHNRSSTN MAHSGITNPLSHSGSSNSSKTTSKPTSPQPPLQTQPPAAKPGYSKSTVVTASNNNNKTTSNVQPRKETVKPPTTEKSVAN LPSEAKDPNASIKRIIEKASAAVSKSHPVGALKQEQKTDHATSHINCEFEDLEHRKTQTSPSHTTPTVKVAKNNNTNNNN NTQNSSDVNEPINTYHHLKAAQLAAKKLQSDTKPSSSDGNAVKQASSKLGVSVNTKASNTKSPVSTTADNEESINRSKNT ALKAASLAAQKLKQQQQEQQQLQVASNESHTHIEPTLNVPIQSSSRTRSKSPAKYFQATIPIVRPETPPTNTSNSNTTKI YSPTPIKSSALHSIPLLQHHGSPSDTDRSSYILQGHESEESTGHAPAKIVAKPTYSMAVPTLRTHNHNHNHNHNRSSVSP ILPTVGNPLDHLLKHHTGRVTSSSPSYDAGSISEPENNTNLSMDTNKNVLNNTNNSNNLDIPHGINELGLPTLHSQDLNK RPLSFHSQTQHSAMNNHPQTTQHVGFKNTTLRKHRKVKSNILSYESERGSNDFTQAAKLAAGTRQGSTSPTTPSSLLAPY TISHSNTLPVSSSASYASSMAIDPHSTVPYHRHHREHKGGILKRVKRKLISGSDKSQDDLVQAPVMIKTTMRKNSKRKTF NEDKPWKYHDARLPTEAEKKRYEGLWAANRGVHLKYMMPKDENSDSDSAFNNVIDSELLLQNNAILTKDEDGNIIAEYET DISMSSGDSESEDDTGEEDSDLDDVEEDSEDEFMSDTDDDPDATHYDIAVTHEETTNNQQQQPGVANLNHNSSLLKSPTP DRISHYNQVSSPLQLSQTSSPSMSPFQSPLHHPDHASLSSSPVTVPSRQYLERRRSSPTFLLSQPDLLSANNTIIRRSSE FAHHGSKIARKLSPPVLNRHHSAAFDVPFSLSHPTPSKGIKLFRNSPPPRSRSPLTCQQYNPYQQLYPPSVDINNSAGQT TDNKENNTINTDTNNTTTPPLSNDTTTTTTTTTAKKNESLEKDIIVKKATAPVEDKQTTEKPRNIVRKPVNINNNSETAA SKTTAIKSTNLDSKSNKEDLNNDNNDTSRRSSSSTTTNNNDKDLPKFLHTKYYRLYRDPKEDIHGYIVRELWRRSRLGDE ILARIWDLVDRNYDCTLDREGFLVGMWLVDQCLYGRKLPTQIDYEVWKSVSRLNVTVDIRLGKKKKRENKEREKRIRKDI KKQAKIARHETLKQEKRKKKEEKKQKHTQHVQKC
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.