Protein

MIA_01355_1

Length
554 amino acids

Browser: contig02:456578-458444-

Protein function

EGGNOG:0PIVCPGUG_03402Poly(A) polymerase
SGD closest match:S000001710PAP1Poly(A) polymerase
CGD closest match:CAL0000194576PAPAPoly(A) polymerase PAPa

Protein alignments

%idAln lengthE-value
MCA_00184_180.952%5250.0MCA_00184_1
A0A060T7P5_BLAAD72.519%5240.0ARAD1D01188p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D01188g PE=4 SV=1
A0A0J9XCR7_GEOCN72.233%5150.0Similar to Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase OS=Geotrichum candidum GN=BN980_GECA10s00450g PE=4 SV=1
A0A167CBY9_9ASCO73.129%5210.0Polynucleotide adenylyltransferase PAP1 OS=Sugiyamaella lignohabitans GN=PAP1 PE=4 SV=1
A0A1E3PL29_9ASCO68.173%5310.0Poly(A) polymerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51260 PE=4 SV=1
Q6C038_YARLI65.175%5140.0YALI0F28039p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F28039g PE=4 SV=1
UniRef50_A0A1V2L0C664.571%5250.0Poly(A) polymerase n=1 Tax=Cyberlindnera fabianii TaxID=36022 RepID=A0A1V2L0C6_CYBFA
PAPA_CANAL65.465%5270.0Poly(A) polymerase PAPa OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAPA PE=3 SV=1
A0A1E4TKQ8_9ASCO61.007%5360.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56050 PE=4 SV=1
PAP_YEAST62.121%5280.0Poly(A) polymerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0395

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 554

Detailed signature matches

  1. Family IPR014492
    Poly(A) polymerase
    1. PIRSF018425 (PolyA_...)
  2. Domain IPR007012
    Poly(A) polymerase, central domain
    1. PF04928 (PAP_central)
  3. Domain IPR002934
    Polymerase, nucleotidyl transferase domain
    1. PF01909 (NTP_transf_2)
  4. Domain IPR011068
    Nucleotidyltransferase, class I, C-terminal-like
    1. SSF55003 (PAP/Archa...)
  5. Domain IPR007010
    Poly(A) polymerase, RNA-binding domain
    1. PF04926 (PAP_RNA-bind)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.14...
  2. G3DSA:3.30.46...
  3. G3DSA:3.30.70...
  4. SSF81301 (Nucleotid...)
  5. SSF81631 (PAP/OAS1 ...)
  6. cd05402 (NT_PAP_TUTase)
  7. mobidb-lite (disord...)

Residue annotation

  1. putative primer-bi...
  2. active site cd05402
  3. metal binding tria...

Protein sequence

>MIA_01355_1
MSSDSKQAQWGVTPPISVAGPTAAENALNDQLIEELKRQGSFESKAETEKRVEVLKLLQELTVEFVRQVSLQKHMTEGMA
KASGGKIFTFGSYRLGVYGPGSDIDTLVVVPKHVSREDFFTVFEKLLRKRPELDEIASVPDAFVPIIKIKMSGISIDLIC
ARLDVSSVPADLTLEDKNLLKNIDEKDLRSLNGTRVTDEILRLVPQQIVFKHALRAIKLWAQRRAIYGNIMGFPGGVAWA
MLVARICQLYPYAVSSTIVGKFFHILTRWTWPQPVLLKPIEDGPLQVRVWNPKLYTQDRSHRMPIITPAYPSMCATHNIT
SSTQKVIMSELVRGGQIMDDIMVGRKSWADLFTKHDFFHRYKYYLSIIAATNGTAEDHLKWSGLVESKLRLLVQKLELLG
TIEISHPFVKSFDKTFLVSEDEATRVADGQVIPGLEPLPKDKINITPEPGKTIVHTTVLYIGLKIVLEGSSKQLDIKWPC
QEFFEACKAWTHYNENTYNIYIKNVRNYDLPNDVFEEGEQRPERSAKNKNKKNLKRKRDINGQVCRESVPAVDA

GO term prediction

Biological Process

GO:0031123 RNA 3'-end processing
GO:0043631 RNA polyadenylation

Molecular Function

GO:0003723 RNA binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0016779 nucleotidyltransferase activity

Cellular Component

GO:0005634 nucleus