Protein

MCA_00184_1

Length
563 amino acids

Gene name: PAP1

Description: Poly(A) polymerase

Browser: contigA:550060-551752-

RNA-seq: read pairs 1396, FPKM 30.6, percentile rank 53.3% (100% = highest expression)

Protein function

Annotation:PAP1Poly(A) polymerase
KEGG:K14376PAP poly(A) polymerase [EC:2.7.7.19]
EGGNOG:0PIVCPGUG_03402Poly(A) polymerase
SGD closest match:S000001710PAP1Poly(A) polymerase
CGD closest match:CAL0000194576PAPAPoly(A) polymerase PAPa

Protein alignments

%idAln lengthE-value
MIA_01355_180.95%5250.0MIA_01355_1
A0A0J9XCR7_GEOCN73.20%5150.0Similar to Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase OS=Geotrichum candidum GN=BN980_GECA10s00450g PE=4 SV=1
A0A060T7P5_BLAAD72.21%5290.0ARAD1D01188p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D01188g PE=4 SV=1
A0A167CBY9_9ASCO71.73%5130.0Polynucleotide adenylyltransferase PAP1 OS=Sugiyamaella lignohabitans GN=PAP1 PE=4 SV=1
A0A1E3PL29_9ASCO67.10%5350.0Poly(A) polymerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51260 PE=4 SV=1
Q6C038_YARLI64.60%5170.0YALI0F28039p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F28039g PE=4 SV=1
PAPA_CANAL63.62%5360.0Poly(A) polymerase PAPa OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAPA PE=3 SV=1
UniRef50_Q9UW2663.62%5360.0Poly(A) polymerase PAPa n=34 Tax=Fungi TaxID=4751 RepID=PAPA_CANAL
A0A1E4TKQ8_9ASCO61.09%5320.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56050 PE=4 SV=1
PAP_YEAST62.12%5200.0Poly(A) polymerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1884

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 563

Detailed signature matches

  1. Family IPR014492
    Poly(A) polymerase
    1. PIRSF018425 (PolyA_...)
  2. Domain IPR007012
    Poly(A) polymerase, central domain
    1. PF04928 (PAP_central)
  3. Domain IPR002934
    Polymerase, nucleotidyl transferase domain
    1. PF01909 (NTP_transf_2)
  4. Domain IPR011068
    Nucleotidyltransferase, class I, C-terminal-like
    1. SSF55003 (PAP/Archa...)
  5. Domain IPR007010
    Poly(A) polymerase, RNA-binding domain
    1. PF04926 (PAP_RNA-bind)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.14...
  2. G3DSA:3.30.46...
  3. G3DSA:3.30.70...
  4. SSF81301 (Nucleotid...)
  5. SSF81631 (PAP/OAS1 ...)
  6. TMhelix
  7. cd05402 (NT_PAP_TUTase)
  8. mobidb-lite (disord...)

Residue annotation

  1. putative primer-bi...
  2. active site cd05402
  3. metal binding tria...

Protein sequence

>MCA_00184_1
MSTQANNNRGVQWGVTPPISLNGPTPEENILNDQLIEELKREGSFESQADTLKRVQVLSTLQKLTQEFVREVSLKKHMTE
GMAQAAGGKIFTFGSYRLGVYGPGSDIDTLVVVPKHVTREDFFTVFEGLLRKLPDLDEIAAIPDAFVPIIKIKISGISID
LICAKLDLATVPEDLTLEDKNLLKNLDEKDLRSLNGTRVTDEILRLVPQPTVFKHALRAIKMWAQRRAIYGNIMGFPGGV
AWAMLVARICQLYPNAVSATIVGKFFHILTRWKWPQPVLLKTIEDGPLQARVWNPKLYIQDRAHRMPIITPAYPSMCATH
NITSSTHKVIMDELKRGGQIVDEIMVGKKTWADLFKKHDFFQKYKYYLSIVAGTKGSAEDHLKWSGLVESKLRLLVNKLE
LLPTILISHPFVKSFDNSYMVTEEQAIRVADGEKIPGVDPLPKDKLDMEPEPGKVIVHTTVLYIGLEIHLEGTKKLDIKW
PCQEFFEACKSWTSYDEDVYSIYIKNYRNYDLPMEVFEPGEERPKKSAVKKRKLISLDNTTPSAATTPTTETPAASSSVS
VKQ

GO term prediction

Biological Process

GO:0031123 RNA 3'-end processing
GO:0043631 RNA polyadenylation

Molecular Function

GO:0003723 RNA binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0016779 nucleotidyltransferase activity

Cellular Component

GO:0005634 nucleus