Protein

MIA_01348_1

Length
158 amino acids


Browser: contig02:438603-439162-

Protein function

EGGNOG:0PN0QSCONCEssential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor (By similarity)
SGD closest match:S000002736SKP1Suppressor of kinetochore protein 1
CGD closest match:CAL0000178736SKP1SCF ubiquitin ligase subunit

Protein alignments

%idAln lengthE-value
MCA_00286_174.684%1581.25e-88MCA_00286_1
Q6CHA1_YARLI64.815%1623.64e-77YALI0A10879p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10879g PE=3 SV=1
A0A0J9X9G2_GEOCN66.038%1594.35e-76Similar to Saccharomyces cerevisiae YDR328C SKP1 Evolutionarily conserved kinetochore protein OS=Geotrichum candidum GN=BN980_GECA06s04696g PE=3 SV=1
UniRef50_D4ARL863.462%1566.74e-71E3 ubiquitin ligase complex SCF subunit sconC n=5 Tax=Trichophyton TaxID=5550 RepID=SKP1_ARTBC
A0A1E3PDZ5_9ASCO65.217%1612.53e-72E3 ubiquitin ligase SCF complex, Skp subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47850 PE=3 SV=1
A0A1E4TAM3_9ASCO57.595%1583.72e-68Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128786 PE=3 SV=1
A0A060T3R6_BLAAD59.494%1585.16e-63ARAD1C39182p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39182g PE=3 SV=1
Q59WE2_CANAL51.553%1611.36e-55SCF ubiquitin ligase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SKP1 PE=3 SV=1
SKP1_YEAST44.503%1911.88e-53Suppressor of kinetochore protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKP1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0309

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 158

Detailed signature matches

    1. SM00512 (skp1_3)
    1. PIRSF028729 (SCF_Skp)
    1. SSF54695 (POZ domain)
    1. PF03931 (Skp1_POZ)
    1. SSF81382 (Skp1 dime...)
    2. PF01466 (Skp1)
Unintegrated signatures no IPR
Unintegrated signatures

Protein sequence

>MIA_01348_1
MVVLVSADDIKYTIDNKTASRSVLIKNMMEDLGDEAAEIPLPYATSNVLKKVIEYCEHHKDDPIPHADEDSEQAKNVTDI
SEWDTKFFQVDQELLFQILLAANYLDIQSLFDAASKTVANMIRNKTPEEIRKTFNIYNDFTPEEEQQIRRENEWAEDH

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

None predicted.

Cellular Component

None predicted.