MIA_01337_1

Protein

Length

1,393 amino acids

Protein function

EGGNOG:	0PFPP	SLN1	Histidine kinase
SGD closest match:	S000001409	SLN1	Osmosensing histidine protein kinase SLN1
CGD closest match:	CAL0000175114	SLN1	Histidine protein kinase SLN1

Protein alignments

	%id	Aln length	E-value
MCA_00291_1	60.000%	420	4.18e-137	MCA_00291_1
A0A0J9X9M6_GEOCN	56.962%	316	5.87e-95	Similar to Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade OS=Geotrichum candidum GN=BN980_GECA06s01517g PE=4 SV=1
UniRef50_A0A0J9X9M6	56.962%	316	1.20e-91	Similar to Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9M6_GEOCN
A0A060TCE8_BLAAD	42.693%	349	2.51e-64	ARAD1D41294p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D41294g PE=4 SV=1
A0A161HHC1_9ASCO	57.360%	197	8.51e-57	Sln1p OS=Sugiyamaella lignohabitans GN=SLN1 PE=4 SV=1
A0A1E4TA96_9ASCO	40.816%	343	5.58e-56	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127796 PE=4 SV=1
Q6C2D5_YARLI	55.779%	199	8.86e-51	YALI0F08789p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F08789g PE=4 SV=1
A0A1E3PT07_9ASCO	36.216%	370	9.04e-48	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49203 PE=4 SV=1
SLN1_CANAL	50.000%	188	1.99e-41	Histidine protein kinase SLN1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SLN1 PE=1 SV=1
SLN1_YEAST	29.948%	384	2.17e-38	Osmosensing histidine protein kinase SLN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLN1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5654
Predicted cleavage: 86

Protein family membership

None predicted.

Domains and repeats

Domain
613 - 692
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
813 - 827
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
831 - 841
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
848 - 866
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
1,244 - 1,367
CheY-like superfamily (IPR011006)
Signal transduction response regulator, receiver domain (IPR001789)
Domain
634 - 887
Histidine kinase domain (IPR005467)
Domain
681 - 889
Histidine kinase-like ATPase, C-terminal domain (IPR003594)

1 200 400 600 800 1000 1200 1393

Detailed signature matches

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  625 - 688
  
  CDD
  cd00082 (HisKA)
2. SSF47384 (Homodimer...)
  
  613 - 692
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
3. SM00388 (HisKA_10)
  
  627 - 692
  
  SMART
  SM00388 (HisKA_10)
4. PF00512 (HisKA)
  
  627 - 690
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  634 - 887
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase-like ATPase, C-terminal domain
1. G3DSA:3.30.56...
  
  696 - 888
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. PF02518 (HATPase_c)
  
  743 - 885
  
  Pfam
  PF02518 (HATPase_c)
3. SSF55874 (ATPase do...)
  
  812 - 889
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
  
  681 - 777
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
4. SM00387 (HKATPase_4)
  
  742 - 887
  
  SMART
  SM00387 (HKATPase_4)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  848 - 866
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  813 - 827
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  831 - 841
  
  PRINTS
  PR00344 (BCTRLSENSOR)
IPR011006

CheY-like superfamily
1. SSF52172 (CheY-like)
  
  1,244 - 1,367
  
  SUPERFAMILY
  SSF52172 (CheY-like)
IPR001789

Signal transduction response regulator, receiver domain
1. PS50110 (RESPONSE_R...)
  
  1,245 - 1,366
  
  PROSITE profiles
  PS50110 (RESPONSE_REGULATORY)
2. PF00072 (Response_reg)
  
  1,246 - 1,361
  
  Pfam
  PF00072 (Response_reg)
3. cd00156 (REC)
  
  1,247 - 1,365
  
  CDD
  cd00156 (REC)
4. SM00448 (REC_2)
  
  1,244 - 1,362
  
  SMART
  SM00448 (REC_2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

119 - 328

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 11

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

958 - 985

COILS
Coil (Coil)

593 - 634

COILS
Coil (Coil)

1,392 - 1,393

COILS
Coil (Coil)
G3DSA:1.10.28...

618 - 688

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.40.50...

1,241 - 1,378

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
NON_CYTOPLASM... (N...)

35 - 100

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

350 - 1,393

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

12 - 34

TMHMM
TMhelix (TMhelix)

328 - 350

TMHMM
TMhelix (TMhelix)

537 - 559

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

329 - 349

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

101 - 118

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

12 - 34

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd00075 (HATPase_c)

747 - 883

CDD
cd00075 (HATPase_c)
mobidb-lite (disord...)

1,101 - 1,120

MobiDB Lite
mobidb-lite (disorder_prediction)

437 - 492

MobiDB Lite
mobidb-lite (disorder_prediction)

1,056 - 1,083

MobiDB Lite
mobidb-lite (disorder_prediction)

1,165 - 1,232

MobiDB Lite
mobidb-lite (disorder_prediction)

375 - 404

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface cd...

631F

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

635I

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

639L

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

642P

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

646I

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

649M

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

665S

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

669I

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

672S

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

676L

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

679L

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)

683L

dimer interface
631F, 635I, 639L, 642P, 646I, 649M, 665S, 669I, 672S, 676L, 679L, 683L
CDD
cd00082 (HisKA)
phosphorylation si...

637H

phosphorylation site
637H
CDD
cd00082 (HisKA)
ATP binding site c...

753N

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

757N

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

760K

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

817V

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

819D

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

821G

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

823G

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

824I

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

851G

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

852L

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

853G

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

854L

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

870L

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

872N

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

876G

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

877L

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)

879V

ATP binding site
753N, 757N, 760K, 817V, 819D, 821G, 823G, 824I, 851G, 852L, 853G, 854L, 870L, 872N, 876G, 877L, 879V
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

757N

Mg2+ binding site
757N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

821G

G-X-G motif
821G, 823G, 851G, 853G
CDD
cd00075 (HATPase_c)

823G

G-X-G motif
821G, 823G, 851G, 853G
CDD
cd00075 (HATPase_c)

851G

G-X-G motif
821G, 823G, 851G, 853G
CDD
cd00075 (HATPase_c)

853G

G-X-G motif
821G, 823G, 851G, 853G
CDD
cd00075 (HATPase_c)
active site cd00156

1,250E

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,251D

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,300D

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,308G

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,329T

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,348F

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,351K

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)

1,352P

active site
1,250E, 1,251D, 1,300D, 1,308G, 1,329T, 1,348F, 1,351K, 1,352P
CDD
cd00156 (REC)
phosphorylation si...

1,300D

phosphorylation site
1,300D
CDD
cd00156 (REC)
intermolecular rec...

1,303M

intermolecular recognition site
1,303M, 1,304P, 1,306M, 1,307D, 1,308G
CDD
cd00156 (REC)

1,304P

intermolecular recognition site
1,303M, 1,304P, 1,306M, 1,307D, 1,308G
CDD
cd00156 (REC)

1,306M

intermolecular recognition site
1,303M, 1,304P, 1,306M, 1,307D, 1,308G
CDD
cd00156 (REC)

1,307D

intermolecular recognition site
1,303M, 1,304P, 1,306M, 1,307D, 1,308G
CDD
cd00156 (REC)

1,308G

intermolecular recognition site
1,303M, 1,304P, 1,306M, 1,307D, 1,308G
CDD
cd00156 (REC)
dimerization inter...

1,351K

dimerization interface
1,351K, 1,352P, 1,353V
CDD
cd00156 (REC)

1,352P

dimerization interface
1,351K, 1,352P, 1,353V
CDD
cd00156 (REC)

1,353V

dimerization interface
1,351K, 1,352P, 1,353V
CDD
cd00156 (REC)

Protein sequence

>MIA_01337_1
MRSVSIGIRPQVILFVFLTMVLSLVILALTTSLYSSNFILNLRTERLQVVSSLKSAQVQQAFSTIYYQAYLMSTRDQLTL
AMARYRAGNNTLENWDSVSSYFNYTFSASTLVVASAVYDTSGSMLFFKSNDSVSYTSYNQALFPTQHDFTELTDDSSSSS
SSSSGLLTSPKLNGTTYLMTLTFPIMGNSSFFVDSEKLYGFISIVATTTSLKSIIEDRTGLENGGLMYFISIPNSNDLPQ
WSFELLLPVTGETYLTGSQQGKLPFVTIPALYPAVASKSGGSLLKTSVINQTNVAVGYARVDNPLASWYVIISEPLSSVF
APVWRIRNVFLAVGLGALGVLSIIVIFLVNKGVQPIYRLKQAAEETTKYFHEISPEESYKGPLPPPPPASSSTHHTSKLK
QSTSTKSFGIKSLFSKFSHRRNPSSLSTITLSESLEEDQKIKQEKAGPNLEDTIHPTFQESSSEASSNQMSKSSQSTINN
KNPITKISSNEKNYLDIQPNIEEDSVQQPETKDVHITKRVCDEKIVNASASTSSSAAAAVAAAAVAAAAAATAAAAATAA
QKRMVVPPHVKIKKPKYLTDELVSLQYSFNRMADELEKQYLHLEDMVRERTKELEAARIQAENANEAKSQFIANITHELR
TPLNGILGMTAVSLTENDPAKVKRSLKVISKSGEVLLHLINDLLTFSKNQVGNVTLDQREFMLSEIVQSVRKAYSKRPNN
RKHVELEFNFVMPELNNVVFLGDCGRITHVILNIFHNSLKFAPDAGPTHLHAQSFSSNMSLNNNNNMLSLPHLANPGSRN
TLITFSDPNSCILEVQVIDQGPGINESILEHVFEPFVQEDQALSRRFGGAGLGLSICKQLVELMGGNISLKNSPDGLVVS
FQIPLYLIRVFSQVPHSTFVFATDAIGIKKYPKQQNLLSIVQQPTTPNVPDYIYDPGTPYDERAQYFSVKTMPPTIPIHQ
KEKLREQQEQHKQLIQNQQQELYRQKTNNLLDQNTTAAVPASEPAQNVAKVKTRPRQHSLTIEIPPAKPLPKTRVFQNDI
HTAAASSLFNFKLKRSSKKLNQQQQQVPQPSSYFEPQHNSNPLGTESVYLRAMEYLKSGNAPTNLENLSSTTPGGQTTSN
MPTPFFEMPLPTLSSLESASKPVTPGSTNGTIRVGAGSISCSNGGSAGNASISGSTTAPSSAGNAQISGTGTSSTTLSAL
GSPTTATASNVTSNGAGNSSVTTPGGGNGGATGTAHAGPISITARILVAEDNLINQDIIRRMLRLEGVKDIDMAMNGEQA
VLRIEDAIRAGIHYDIVFLDVQMPRMDGLEAARIIRSQLGYPYPIVALTAYADDDNARQCYDAGMSDFLEKPVNRERLRE
VLVEYCPTDALHEALMPTGGFDSLLNPPTTPLS

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component