Protein

MIA_01319_1

Length
549 amino acids

Browser: contig02:355824-357474+

Protein function

EGGNOG:0PHWWHTS1histidyl-tRNA synthetase
SGD closest match:S000006237HTS1Histidine--tRNA ligase, mitochondrial
CGD closest match:CAL0000190585HTS1Histidine--tRNA ligase

Protein alignments

%idAln lengthE-value
A0A0J9X4T1_GEOCN81.589%5160.0Similar to Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA02s00582g PE=3 SV=1
MCA_00621_183.752%5170.0MCA_00621_1
A0A161HFB6_9ASCO75.388%5160.0Histidine--tRNA ligase OS=Sugiyamaella lignohabitans GN=HTS1 PE=3 SV=1
A0A1E3PKW8_9ASCO72.534%5170.0Histidyl-tRNA synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46520 PE=3 SV=1
A0A060T1A0_BLAAD71.648%5220.0ARAD1C18480p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C18480g PE=3 SV=1
Q6C624_YARLI68.872%5140.0YALI0E13123p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E13123g PE=3 SV=1
UniRef50_G0W3A162.786%5240.0Uncharacterized protein n=37 Tax=saccharomyceta TaxID=716545 RepID=G0W3A1_NAUDC
SYH_YEAST62.597%5160.0Histidine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HTS1 PE=1 SV=2
Q5AJX0_CANAL61.702%5170.0Histidine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HTS1 PE=3 SV=1
A0A1E4TM04_9ASCO63.056%5170.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1385 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0383

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 549

Detailed signature matches

  1. Family IPR004516
    Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
    1. PIRSF001549 (His-tR...)
  2. Family IPR015807
    Histidine-tRNA ligase
    1. MF_00127 (His_tRNA_...)
  3. Domain IPR006195
    Aminoacyl-tRNA synthetase, class II
    1. PS50862 (AA_TRNA_LI...)
  4. Domain IPR004154
    Anticodon-binding
    1. SSF52954 (Class II ...)
    2. G3DSA:3.40.50...
    3. PF03129 (HGTP_antic...)
  5. Domain IPR033656
    Histidyl-anticodon-binding
    1. cd00859 (HisRS_anti...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.30.93...
  3. NON_CYTOPLASM... (N...)
  4. PF13393 (tRNA-synt_His)
  5. SIGNAL_PEPTIDE (Sig...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SSF55681 (Class II ...)
  10. cd00773 (HisRS-like...)
  11. mobidb-lite (disord...)

Residue annotation

  1. dimer interface cd...
  2. motif 1 cd00773
  3. active site cd00773
  4. motif 2 cd00773
  5. motif 3 cd00773
  6. anticodon binding ...

Protein sequence

>MIA_01319_1
MSAEQATAPAAAPAAAAPAAAAPKKSNKKEKAPQFTLKTPKGTKDWSDKDMILRSAVFDTLTKVFKRHGGVTIDTPVFEL
REILSGKYGEDSKLIYNLEDQGGELTSLRYDLTVPFARFVAMNGIQQIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIA
GDYESMVPDAEILSIAVEGLTALNIKDFTIKVNHRKILDGIFQLCGVKEEDIRKVSSAVDKLDKLPWEEVKKEMVVDKNQ
PEEVADKIGEYVRIKGHFKDVLDRLSGDEQLMSNPSAAAGVKDMATAYQYLTAFNVVDYLSFDLSLARGLDYYTGLIYEA
VTAASAPPPKPAAAEGAAAAEGAAAAASSGKKDKKKSKKNSELDDDDNSENVGVGSIMAGGRYDNLVGMFAGSSKKNASI
PCVGVSFGVERLFSLIKAREGLYDKVRPTSTQVYVMAFGGGPQWDGFLKERMEVAKVLWEGGIEAEFLYKTKPKPQKQFE
AAEKTGCPFAVILGQEEFANKVVKVKELGLGDDADKGIDVPLTEAVEYIKKKLSEKHNGLDEAVKLLSL

GO term prediction

Biological Process

GO:0006427 histidyl-tRNA aminoacylation

Molecular Function

GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm