Protein

MIA_01309_1

Length
469 amino acids

Browser: contig02:327572-329098-

Protein function

EGGNOG:0PHM62-oxo acid dehydrogenases acyltransferase
SGD closest match:S000002555KGD2Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
CGD closest match:CAL0000176210KGD2Alpha-ketoglutarate dehydrogenase

Protein alignments

%idAln lengthE-value
MCA_00189_167.089%4740.0MCA_00189_1
A0A0J9X8G6_GEOCN59.395%4630.0Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Geotrichum candidum GN=BN980_GECA05s05961g PE=3 SV=1
A0A060SX06_BLAAD56.833%4611.10e-178Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A04730g PE=3 SV=1
UniRef50_S8BTG757.388%4674.39e-164Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex n=1 Tax=Dactylellina haptotyla (strain CBS 200.50) TaxID=1284197 RepID=S8BTG7_DACHA
Q6C806_YARLI55.263%4566.85e-166Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23815g PE=3 SV=1
A0A1E4TF91_9ASCO50.427%4682.91e-155Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2169 PE=3 SV=1
A0A1E3PT47_9ASCO47.007%4511.41e-132Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68417 PE=3 SV=1
A0A167E496_9ASCO54.459%3143.51e-113Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Sugiyamaella lignohabitans GN=KGD2 PE=3 SV=1
ODO2_YEAST33.493%2096.65e-27Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KGD2 PE=1 SV=2
A0A1D8PTH3_CANAL29.880%2511.54e-25Alpha-ketoglutarate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KGD2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9951
Predicted cleavage: 15

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 469

Detailed signature matches

  1. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  2. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  3. Domain IPR004167
    E3-binding domain
    1. SSF47005 (Periphera...)
    2. G3DSA:4.10.32...
    3. PF02817 (E3_binding)
  4. Domain IPR001078
    2-oxoacid dehydrogenase acyltransferase, catalytic domain
    1. PF00198 (2-oxoacid_dh)
  5. SITE IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.55...
  3. G3DSA:3.90.11...
  4. SSF52777 (CoA-depen...)
  5. cd06849 (lipoyl_domain)
  6. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction sur...
  2. lipoyl attachment ...

Protein sequence

>MIA_01309_1
MLSSRVLTRITPRLKTLARNFHYTPLALQVKPFLLADIGEGIKECEVIQWFVQPGARIEEFEPICEVQSDKASVEITSRY
NGVIKQLHYDVGQMALVGKPLVDIDVEEDGQSEESAVTEKQEQEVQESKEPAVSVASAVSPESSNGLHKQTGKFATLATP
AVRRLTKELGIDISYIPGTGKDGRVLKEDVLTFHAKGNRTPSLEPSLSSTEEKVGAASPLKTAVSQEEQTVPLTPIQSQM
FKAMTNSLAIPHFLYTEEVQIDGLTGMRAKINKLLKKGAFGKETPEKISYMPFFIKAMSIALKEFPIVNSRVTFDSVSGK
PLLVHRPFHNIGVAMDTPSGLVVPNIKNVQDLSVLEIAAELNRLQALGAANKFSAADLQGSTISISNIGNVGGTYLMPVI
VDSQVAIVGIGKARVIPSFDDKMQVVAKQVINTSWSGDHRVLDGMTMAKMADRFKQLLEDPELMIVNIR

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

None predicted.