Protein

MCA_00189_1

Length
479 amino acids

Description: dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase

Browser: contigA:567903-569556+

RNA-seq: read pairs 2897, FPKM 74.6, percentile rank 73.9% (100% = highest expression)

Protein function

Annotation:dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase
KEGG:K09699DBT 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
EGGNOG:0PHM62-oxo acid dehydrogenases acyltransferase
SGD closest match:S000002555KGD2Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
CGD closest match:CAL0000176210KGD2Alpha-ketoglutarate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_01309_167.09%4740.0MIA_01309_1
A0A0J9X8G6_GEOCN59.28%4690.0Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Geotrichum candidum GN=BN980_GECA05s05961g PE=3 SV=1
A0A060SX06_BLAAD57.91%4682e-177Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A04730g PE=3 SV=1
Q6C806_YARLI53.86%4792e-162Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23815g PE=3 SV=1
UniRef50_Q6C80653.86%4794e-159Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex n=78 Tax=saccharomyceta TaxID=716545 RepID=Q6C806_YARLI
A0A1E4TF91_9ASCO50.31%4834e-154Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2169 PE=3 SV=1
A0A1E3PT47_9ASCO46.94%4583e-128Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68417 PE=3 SV=1
A0A167E496_9ASCO55.28%3223e-114Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Sugiyamaella lignohabitans GN=KGD2 PE=3 SV=1
ODO2_YEAST31.85%2489e-27Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KGD2 PE=1 SV=2
A0A1D8PTH3_CANAL31.45%2486e-23Alpha-ketoglutarate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KGD2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9137
Predicted cleavage: 31

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 479

Detailed signature matches

  1. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  2. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  3. Domain IPR004167
    E3-binding domain
    1. SSF47005 (Periphera...)
    2. G3DSA:4.10.32...
    3. PF02817 (E3_binding)
  4. Domain IPR001078
    2-oxoacid dehydrogenase acyltransferase, catalytic domain
    1. PF00198 (2-oxoacid_dh)
  5. SITE IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.55...
  3. SSF52777 (CoA-depen...)
  4. cd06849 (lipoyl_domain)
  5. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction sur...
  2. lipoyl attachment ...

Protein sequence

>MCA_00189_1
MLRNQLYRLNAVVNPRLLGKRSFHNSNFLFKIKPFLLADIGEGIKECEVIQWFVQPGARIEEFDPICEVQSDKASVEITS
RYTGVIKALHYDVGQMALVGKPLIDIDVEDGSSEPSNEPEPAVGNAESASAASSEPAPSSSSAASSGEPVQQTGKYATLA
TPAVRRISKELNIDISFVKGTGKDGRVLKEDVLAFHASGGKTPTSSSSTSNTQSTTSQPQKQPQQPLLEETIVPLTPIQN
QMFKTMTNSLNIPHFLYTEEVGIDSLTQTRKKINSLLAKKAFGPDLPTKISYMPLFIKALSLALTEYPIVNARVTFDAQT
SKPQIVMRPSHNIGIAMDTPSGLVVPNIKNVERLSILEIASELSRLQQLGAANKFGSQDLQGGTVSLSNIGNVGGTYLGP
VIVDSQVAIVGIGRARTIPSFAVDESTGAADFGKVVPKQVINTSWSGDHRVLDGMTMAKMADRFKEYLESPELMMLNLK

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

None predicted.