Protein

MIA_01290_1

Length
446 amino acids

Browser: contig02:258771-260173+

Protein function

EGGNOG:0PGTNSUB2ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity
SGD closest match:S000002242SUB2ATP-dependent RNA helicase SUB2
CGD closest match:CAL0000200240SUB2ATP-dependent RNA helicase

Protein alignments

%idAln lengthE-value
MCA_00214_294.828%4060.0MCA_00214_2
A0A0J9XIJ7_GEOCN88.614%4040.0Similar to Saccharomyces cerevisiae YDL084W SUB2 Component of the TREX complex required for nuclear mRNA export OS=Geotrichum candidum GN=BN980_GECA19s00604g PE=4 SV=1
A0A060TG37_BLAAD89.027%4010.0ARAD1D20042p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20042g PE=4 SV=1
A0A1E3PSC2_9ASCO85.714%4060.0p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_30478 PE=4 SV=1
A0A1D8PKZ3_CANAL81.360%3970.0ATP-dependent RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SUB2 PE=4 SV=1
A0A1E4TDU5_9ASCO79.699%3990.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24549 PE=4 SV=1
SUB2_YARLI79.064%4060.0ATP-dependent RNA helicase SUB2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SUB2 PE=3 SV=2
UniRef50_O1379278.446%3990.0ATP-dependent RNA helicase uap56 n=174 Tax=Eukaryota TaxID=2759 RepID=SUB2_SCHPO
SUB2_YEAST77.834%3970.0ATP-dependent RNA helicase SUB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUB2 PE=1 SV=1
A0A167D571_9ASCO85.714%2521.20e-161ATP-dependent RNA helicase SUB2 OS=Sugiyamaella lignohabitans GN=SUB2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0308

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 446

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00079 (HELICc)
  3. cd00268 (DEADc)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MIA_01290_1
MSHEGEEELLDYSDSEDIAVSAPATAAPAAAAEGTTTSTEDNLAIKQENGDKKGSYVGIHSTGFKDFLLKPELVRAITDS
GFEHPSEVQQVCIPQSILGTDVLCQAKSGLGKTAVFVLSTLQQIEPVDGEVSVIVLCHTRELAYQIKNEYSRFSKYLPDV
RTSVFYGGTPIAKDIALIKDKTTCPHIIVGTPGRLNALVRDKFLRLNNIKTFVIDEADKVLEQPDMRRDVQEIFRSTPHQ
KQVMMFSATLSQEIRPICKKFMQNPLEIYVDDETKLTLHGLQQYYVKLAEREKNRKLNEILDTLEFNQVIIFVKSTKRAD
ELNRLLNECNFPSIAVHSGIPQEERIERYKSFKTFEKRICVATDVFGRGIDIERINLAINYDLPDNADQYLHRVGRAGRF
GTKGLAVSFVSTEEDQQVLDSIQSRFEVDISPFPEEGIDASTYMNS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.