Protein

MIA_01270_1

Length
733 amino acids

Browser: contig02:215041-217243-

Protein function

EGGNOG:0PH1JFG05198.1nadh-ubiquinone oxidoreductase
CGD closest match:CAL0000186451CAALFM_CR10140WAUncharacterized protein

Protein alignments

%idAln lengthE-value
MCA_05477_183.518%7220.0MCA_05477_1
A0A0J9XHA2_GEOCN81.579%7220.0NUAM subunit of mitochondrial NADH:ubiquinone oxidoreductase (Complex I), putative OS=Geotrichum candidum GN=BN980_GECA17s02276g PE=3 SV=1
A0A167CRB9_9ASCO75.242%7230.0NADH:ubiquinone oxidoreductase 78kD subunit OS=Sugiyamaella lignohabitans GN=AWJ20_245 PE=3 SV=1
UniRef50_P2491871.089%7160.0NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial n=1020 Tax=root TaxID=1 RepID=NDUS1_NEUCR
F2Z6F1_YARLI71.056%7290.0YALI0D05467p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D05467g PE=3 SV=1
A0A060TFC5_BLAAD68.927%7080.0ARAD1D22066p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D22066g PE=3 SV=1
A0A1E4THB3_9ASCO69.385%6990.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2860 PE=3 SV=1
A0A1D8PU51_CANAL70.707%6930.0Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR10140WA PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9851
Predicted cleavage: 26

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 733

Detailed signature matches

  1. Family IPR010228
    NADH:ubiquinone oxidoreductase, subunit G
    1. TIGR01973
  2. Domain IPR012675
    Beta-grasp domain
    1. G3DSA:3.10.20.30
  3. Domain IPR001041
    2Fe-2S ferredoxin-type iron-sulfur binding domain
    1. SSF54292 (2Fe-2S fe...)
    2. cd00207 (fer2)
    3. PS51085 (2FE2S_FER_2)
  4. Domain IPR019574
    NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
    1. PF10588 (NADH-G_4Fe...)
    2. SM00929 (NADH_G_4Fe...)
  5. Domain IPR006963
    Molybdopterin oxidoreductase, 4Fe-4S domain
    1. PS51669 (4FE4S_MOW_...)
  6. Domain IPR006656
    Molybdopterin oxidoreductase
    1. PF00384 (Molybdopterin)
  7. Domain IPR015405
    NADH-quinone oxidoreductase, chain G, C-terminal
    1. PF09326 (NADH_dhqG_C)
  8. SITE IPR000283
    NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
    1. PS00641 (COMPLEX1_7...)
    2. PS00643 (COMPLEX1_7...)
    3. PS00642 (COMPLEX1_7...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.70.20
  2. G3DSA:3.40.50...
  3. PF13510 (Fer2_4)
  4. SSF53706 (Formate d...)
  5. SSF54862 (4Fe-4S fe...)
  6. cd02773 (MopB_Res-C...)

Residue annotation

  1. catalytic loop cd0...
  2. iron binding site ...

Protein sequence

>MIA_01270_1
MLSRSRLLSKQVSSISRLAGVAGRSQPFSSSAPRPKEVEVTIDGKKVTVEAGSALIQACEKAGVTVPRYCYHEKLAIAGN
CRMCLVDVARAPKPVASCAFPVGPGMVVRTDTERVKKAREGVMEFMLSNHPLDCPVCDQGGECDLQDQSMRYGRDRSRYH
EVSGKRAVEDKDIGPLVKTSMNRCIHCTRCVRFSNDVAGAPELGTAGRGNDMQIGTYLQKNLNSELSGNVIDLCPVGALT
SKPYAFRARPWELKRTESIDVLDALGSNIRVDSRGVEVMRVIPRVNDDINEEWISDKTRFAVDGLKTQRLTTPLIKVGNS
FETATWNDALSTIADAFKSLNVSGNELKAVTGDLVEVESLVALKDLVNALGSENLATDSSNLPPAHGVDIRSNYLFNSTI
SGIEEADAILLVGTNPRHEAAVLNARIRKQFLRSNLEIGLVGENFDSTFWVKHFGDNHSALVETLKGEFGSKLAAAKRPL
IIVGSSIAEHPDAGAFFKTIGNFVTKHESNFLTEEWNGYNVLQRAASHAGAFDVGFVPPSKEVAETTPKFVWLLGADEIN
PSDIPKDAFVVYQGHHGDVGAQFADVILPGAAYTEKTGTYVNTEGRAQTTRAAVGPPGVAREDWKIIRAASEYLGSPLPY
DDIYEIRNRLGEIAPHLLRHEIIEPSSLAATGVKEQLVAENKHAPVSDAKLSKAIANFYFTDAISRSSPTMAKCSIAFKN
QPADEAQSAAASA

GO term prediction

Biological Process

GO:0042773 ATP synthesis coupled electron transport
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0051536 iron-sulfur cluster binding

Cellular Component

GO:0016020 membrane