Protein

MCA_05477_1

Length
726 amino acids

Description: NADH-ubiquinone oxidoreductase subunit

Browser: contigD:1421609-1423790+

RNA-seq: read pairs 18638, FPKM 316.8, percentile rank 92.1% (100% = highest expression)

Protein function

Annotation:NADH-ubiquinone oxidoreductase subunit
KEGG:K03934NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.5.3 1.6.99.3]
EGGNOG:0PH1JFG05198.1nadh-ubiquinone oxidoreductase
CGD closest match:CAL0000186451CAALFM_CR10140WAUncharacterized protein

Protein alignments

%idAln lengthE-value
MIA_01270_183.01%7300.0MIA_01270_1
A0A0J9XHA2_GEOCN81.48%7290.0NUAM subunit of mitochondrial NADH:ubiquinone oxidoreductase (Complex I), putative OS=Geotrichum candidum GN=BN980_GECA17s02276g PE=3 SV=1
A0A167CRB9_9ASCO75.07%7220.0NADH:ubiquinone oxidoreductase 78kD subunit OS=Sugiyamaella lignohabitans GN=AWJ20_245 PE=3 SV=1
F2Z6F1_YARLI71.83%7030.0YALI0D05467p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D05467g PE=3 SV=1
UniRef50_P2491870.82%6990.0NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial n=1020 Tax=root TaxID=1 RepID=NDUS1_NEUCR
A0A060TFC5_BLAAD69.60%7170.0ARAD1D22066p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D22066g PE=3 SV=1
A0A1D8PU51_CANAL70.15%7170.0Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR10140WA PE=3 SV=1
A0A1E4THB3_9ASCO69.22%7180.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2860 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9962
Predicted cleavage: 31

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 726

Detailed signature matches

  1. Family IPR010228
    NADH:ubiquinone oxidoreductase, subunit G
    1. TIGR01973
  2. Domain IPR012675
    Beta-grasp domain
    1. G3DSA:3.10.20.30
  3. Domain IPR001041
    2Fe-2S ferredoxin-type iron-sulfur binding domain
    1. SSF54292 (2Fe-2S fe...)
    2. cd00207 (fer2)
    3. PS51085 (2FE2S_FER_2)
  4. Domain IPR019574
    NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
    1. PF10588 (NADH-G_4Fe...)
    2. SM00929 (NADH_G_4Fe...)
  5. Domain IPR006963
    Molybdopterin oxidoreductase, 4Fe-4S domain
    1. PS51669 (4FE4S_MOW_...)
  6. Domain IPR006656
    Molybdopterin oxidoreductase
    1. PF00384 (Molybdopterin)
  7. Domain IPR015405
    NADH-quinone oxidoreductase, chain G, C-terminal
    1. PF09326 (NADH_dhqG_C)
  8. SITE IPR000283
    NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
    1. PS00641 (COMPLEX1_7...)
    2. PS00643 (COMPLEX1_7...)
    3. PS00642 (COMPLEX1_7...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. PF13510 (Fer2_4)
  3. SSF53706 (Formate d...)
  4. SSF54862 (4Fe-4S fe...)
  5. cd02773 (MopB_Res-C...)

Residue annotation

  1. catalytic loop cd0...
  2. iron binding site ...

Protein sequence

>MCA_05477_1
MLSTSNLLRRNALSISRLANRKFSSSVMRKAEVELTIDGKKVSIEAGSALIQACEKAGVTVPRYCYHEKLAIAGNCRMCL
VDLERAPKPVASCAFPVGPGMVVRTDTERVKKAREGVMEMMLSNHPLDCPVCDQGGECDLQDQSMRYGRDRGRFHEISGK
RAVEDKDIGPLVKTSMNRCIQCTRCVRFSNDVAGAPELGTSGRGNDMQIGTYLQRNLNSELSGNIIDLCPVGALTSKPYA
FHARPWELKKTESIDVLDALGSNIRIDSRGVEVMRVLPRINDDINEEWISDKTRFACDGLKTQRLTTPLIKVGNSFETAT
WNDALSSIAEAYNNLGVKGDEFKGVAGDLVEVESLVALKDLANSLGSENLTLDNVGTPAHGVDFRSNYTFNSTISGIEEA
DVILLVGTNPRHEAPVLNARIRKQFLRSNLEIGLVGENFESTFWVEHLGQDQAALAEALKGEFGSKLANAKKPLIIVGSA
VAENKDAGAIFKTIGSFISKHESNFITPEWNGYNVLQRAASHTGAFDVGFVPPSPETASTKPKMIWLLGADEIKPSDIPE
DAFVIYQGHHGDVGAQYADVILPGAAYTEKTATYVNTEGRAQTTRAAVGPPGVAREDWKIIRAASEYLGSALPYDDIYEI
RNRLGEIAPHLLRHEVIEPASLASVGIKEALVHANKSSKPVGEKLVKPIKNFYLTDSISRSSPTMAKCTVAFNNQPSDEQ
PKVAFG

GO term prediction

Biological Process

GO:0042773 ATP synthesis coupled electron transport
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0051536 iron-sulfur cluster binding

Cellular Component

GO:0016020 membrane