MIA_01238_1

Protein

Length

1,510 amino acids

Protein function

EGGNOG:	0PFDT	PGUG_02803	chloride channel
SGD closest match:	S000003801	GEF1	Anion/proton exchange transporter GEF1
CGD closest match:	CAL0000179877	GEF2	Gef2p

Protein alignments

	%id	Aln length	E-value
MCA_05986_1	46.436%	926	0.0	MCA_05986_1
A0A0J9X5L9_GEOCN	50.381%	788	0.0	Similar to Saccharomyces cerevisiae YJR040W GEF1 Voltage-gated chloride channel localized to the golgi OS=Geotrichum candidum GN=BN980_GECA03s02309g PE=4 SV=1
UniRef50_A0A0J9X5L9	50.381%	788	0.0	Similar to Saccharomyces cerevisiae YJR040W GEF1 Voltage-gated chloride channel localized to the golgi n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5L9_GEOCN
A0A060TIN6_BLAAD	43.039%	862	0.0	ARAD1D47938p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D47938g PE=4 SV=1
A0A1E4TKP3_9ASCO	41.087%	791	1.13e-151	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30518 PE=4 SV=1
Q6CBC6_YARLI	49.204%	565	5.24e-146	YALI0C20053p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C20053g PE=4 SV=1
A0A1E3PRG8_9ASCO	51.356%	553	2.41e-148	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_5216 PE=4 SV=1
A0A1D8PS75_CANAL	39.242%	818	5.82e-137	Gef2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GEF2 PE=4 SV=1
A0A167DQA5_9ASCO	48.068%	414	7.19e-102	Gef1p OS=Sugiyamaella lignohabitans GN=GEF1 PE=4 SV=1
GEF1_YEAST	34.266%	429	2.55e-47	Anion/proton exchange transporter GEF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEF1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0357

Protein family membership

Chloride channel, voltage gated (IPR001807)

Domains and repeats

Domain
452 - 1,121
Chloride channel, core (IPR014743)

1 200 400 600 800 1000 1200 1400 1510

Detailed signature matches

IPR001807

Chloride channel, voltage gated
1. PR00762 (CLCHANNEL)
  
  755 - 774
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  1,048 - 1,064
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  670 - 687
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  1,066 - 1,085
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  701 - 720
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  1,105 - 1,119
  
  PRINTS
  PR00762 (CLCHANNEL)
2. PF00654 (Voltage_CLC)
  
  670 - 1,097
  
  Pfam
  PF00654 (Voltage_CLC)
IPR014743

Chloride channel, core
1. SSF81340 (Clc chlor...)
  
  551 - 578
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  1,043 - 1,120
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  665 - 903
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  959 - 1,010
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  458 - 500
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
2. G3DSA:1.10.30...
  
  452 - 1,121
  
  GENE3D
  G3DSA:1.10.3080.10 (G3DSA:1.10.3080.10)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

738 - 748

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

581 - 697

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

806 - 825

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 466

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,101 - 1,510

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

883 - 961

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,008 - 1,048

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:3.10.58...

1,152 - 1,510

GENE3D
G3DSA:3.10.580.10 (G3DSA:3.10.580.10)
NON_CYTOPLASM... (N...)

852 - 862

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

716 - 720

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

774 - 784

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

980 - 984

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

486 - 560

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,075 - 1,079

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

784 - 806

TMHMM
TMhelix (TMhelix)

821 - 843

TMHMM
TMhelix (TMhelix)

558 - 580

TMHMM
TMhelix (TMhelix)

467 - 485

TMHMM
TMhelix (TMhelix)

749 - 771

TMHMM
TMhelix (TMhelix)

864 - 886

TMHMM
TMhelix (TMhelix)

991 - 1,013

TMHMM
TMhelix (TMhelix)

698 - 715

TMHMM
TMhelix (TMhelix)

1,040 - 1,062

TMHMM
TMhelix (TMhelix)

962 - 984

TMHMM
TMhelix (TMhelix)

1,069 - 1,091

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

698 - 715

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,080 - 1,100

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

561 - 580

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

467 - 485

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

962 - 979

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

749 - 773

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,049 - 1,074

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

826 - 851

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

863 - 882

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

985 - 1,007

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

785 - 805

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

721 - 737

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd03684 (ClC_3_like)

670 - 1,118

CDD
cd03684 (ClC_3_like)
cd04591 (CBS_pair_E...)

1,448 - 1,504

CDD
cd04591 (CBS_pair_EriC_assoc_euk_bac)
mobidb-lite (disord...)

300 - 334

MobiDB Lite
mobidb-lite (disorder_prediction)

625 - 660

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 94

MobiDB Lite
mobidb-lite (disorder_prediction)

153 - 207

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative Cl- selec...

674G

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

675S

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

676G

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

677V

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

678P

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

716G

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

717K

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

718E

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

719G

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

720P

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

984G

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

985I

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

986Y

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

987V

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

988P

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)

1,106Y

putative Cl- selectivity filter
674G, 675S, 676G, 677V, 678P, 716G, 717K, 718E, 719G, 720P, 984G, 985I, 986Y, 987V, 988P, 1,106Y
CDD
cd03684 (ClC_3_like)
putative pore gati...

718E

putative pore gating glutamate residue
718E
CDD
cd03684 (ClC_3_like)
putative H+/Cl- co...

775E

putative H+/Cl- coupling transport residue
775E
CDD
cd03684 (ClC_3_like)

Protein sequence

>MIA_01238_1
MSSTSASETDDNTNAVASEPDELSCRLQQEGSEVTGISSSSNVPRGSDDDFVHSKENGPSLEADFEHPSLLVSKPQLKNR
PPSTSHLTFELPAKPGETPIGSIAGEVTPPISLNKHIFGTHNHAKSFGHNVSNHNNAIGLIRARSSSDIRQFRTNSDQPL
PTAVRVDQGLRPPHGCRSLSSSASYTRQQQQQQQQQQQHPSPKPYQQRLSSIKSYINSAKKATADFLSPNDSEIPGHVPN
LRSPRLSVAKPQQGTRFDIFDDSESIRSIYLNNDIFVSNHPSRAHSRAGSILNMPHSSVNQASDNVATDTTDNNPLNTQQ
NPESSMGSEIGSSISSVSNKKLPYNAPFTASCSGSLIGPSNLSRTYSFNRAHRTSEASDQMSAYGSIIYENITEENSDVS
SNEEDKNDVKNFTTDLGKDIDERRFYDDFTTIDWVRDVINISARHKYIETLPGLRGRIVRIADSCQGWVLIIIVAFCFAT
IAYLIDKMEEFVFGLKFGVCTTNIFLTKKKCCSGVKTNLIEIEDVCTSFRSWESIILDESNWAGYVVTKTFGPVNRQLVG
FMMYTLFAISFALIAGELTLRSKLSTLVSSKINFEDEKYARFNTFKKDNIQSGSIGNTSVLTQSVDNSAQRSETLSSSRI
PRTETSSLLPDKASTSKLSQKSSAHSRTIYACSGSGVPEVKTILSGFVIRGFLGTKTIFLKSIGLVFSIASGLAVGKEGP
FVHLATCVGNVSCRLFKKYAENDLKRRQVLSAASSAGVALAFGSPIGGVLFALEEVSYYFLPHQLFRIFFCALMSALFLV
FYNPYGRGNIVLFEVSYNSNWMMWELVCFILLGVCGGVYGSVFCKFAGIWWPKFFRSFKIIKNHPLFEVMLLALVTSCLG
YFNMYTRSAVAEVLLLLARPCTNQLFSNSPANITTVNYSTSHFLTSLLSQSDSLELNESYLESSNALCPQDPTHIPNILK
PLLYALVAKILLTAITFGAKIPAGIYVPSMVVGALFGRIFGLVLQYLGHLWTLKLEEISDCSFSKLGFMTLLWSVKDVSY
AVSRIVPGVYAMAGAGAFMAGVTRMNLTLAVILFELTGSLHYVMPFSISVLVSNWAAALIEERSLYEILIEKNEFPYMDN
RVSLSFDSKLADMVPTLKRGEIVIDIGAGNYVSTKQLVSILSQLHSRGEFDACIAIVRGPILFGMISAPELEFALDKICE
QCISAVGNNKGQFESGGLSFPLQAEAMLKFESVMCRLSLQDDLNEDELYKYRNCYYDSSFGLPFGAMNRQNTEEAFEHVH
YSLGALQRKGTQDAGAKRQDSSTLNSNNVNLTGLHEHARQRHASFTSLYKTVHKNPPTNTGTYFDSAPFGSTVQNRDVFS
SPSSSASTIIRGASLSVHASKAAAQESVDFDFGRPGGGSLSALPQEIISNEPNTVADDDDRGVENEYEEEILPFSGSARN
LDGKVEVLVSDLTSYINRAPIVLDVQSPLALVQMFFVKLGVRAIGVLKDGQFVGVLHKKRFKEYCHQISA

GO term prediction

Biological Process

GO:0006821 chloride transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity

Cellular Component

GO:0016020 membrane

Filter view on

Entry type

Status

Per-residue features