MCA_05986_1

Protein

Length

1,624 amino acids

RNA-seq: read pairs 96, FPKM 0.7, percentile rank 8.1% (100% = highest expression)

Protein function

KEGG:	K05012	CLCN3_4_5	chloride channel 3/4/5
EGGNOG:	0PFDT	PGUG_02803	chloride channel
SGD closest match:	S000003801	GEF1	Anion/proton exchange transporter GEF1
CGD closest match:	CAL0000179877	GEF2	Gef2p

Protein alignments

	%id	Aln length	E-value
MIA_01238_1	45.85%	951	0.0	MIA_01238_1
A0A060TIN6_BLAAD	38.79%	946	3e-155	ARAD1D47938p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D47938g PE=4 SV=1
UniRef50_A0A060TIN6	38.79%	946	6e-152	ARAD1D47938p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TIN6_BLAAD
Q6CBC6_YARLI	44.66%	665	1e-129	YALI0C20053p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C20053g PE=4 SV=1
A0A0J9X5L9_GEOCN	44.71%	539	6e-110	Similar to Saccharomyces cerevisiae YJR040W GEF1 Voltage-gated chloride channel localized to the golgi OS=Geotrichum candidum GN=BN980_GECA03s02309g PE=4 SV=1
A0A1E3PRG8_9ASCO	42.91%	515	3e-104	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_5216 PE=4 SV=1
A0A167DQA5_9ASCO	44.34%	433	5e-99	Gef1p OS=Sugiyamaella lignohabitans GN=GEF1 PE=4 SV=1
A0A1E4TKP3_9ASCO	43.09%	499	9e-89	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30518 PE=4 SV=1
A0A1D8PS75_CANAL	38.81%	505	5e-78	Gef2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GEF2 PE=4 SV=1
GEF1_YEAST	30.12%	488	8e-30	Anion/proton exchange transporter GEF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEF1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0421

Protein family membership

Chloride channel, voltage gated (IPR001807)

Domains and repeats

Domain
552 - 1,260
Chloride channel, core (IPR014743)

1 200 400 600 800 1000 1200 1400 1624

Detailed signature matches

IPR001807

Chloride channel, voltage gated
1. PR00762 (CLCHANNEL)
  
  806 - 825
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  1,245 - 1,259
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  775 - 792
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  1,188 - 1,204
  
  PRINTS
  PR00762 (CLCHANNEL)
  
  1,206 - 1,225
  
  PRINTS
  PR00762 (CLCHANNEL)
2. PF00654 (Voltage_CLC)
  
  772 - 1,238
  
  Pfam
  PF00654 (Voltage_CLC)
IPR014743

Chloride channel, core
1. SSF81340 (Clc chlor...)
  
  770 - 994
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  1,183 - 1,260
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  557 - 603
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  1,097 - 1,148
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
  
  676 - 703
  
  SUPERFAMILY
  SSF81340 (Clc chloride channel)
2. G3DSA:1.10.30...
  
  552 - 1,259
  
  GENE3D
  G3DSA:1.10.3080.10 (G3DSA:1.10.3080.10)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

879 - 889

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,076 - 1,095

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,241 - 1,624

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,146 - 1,188

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

955 - 974

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

589 - 685

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

1,622 - 1,624

COILS
Coil (Coil)
NON_CYTOPLASM... (N...)

706 - 853

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

912 - 930

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

994 - 1,053

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,118 - 1,122

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,215 - 1,219

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 569

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

929 - 951

TMHMM
TMhelix (TMhelix)

686 - 705

TMHMM
TMhelix (TMhelix)

890 - 909

TMHMM
TMhelix (TMhelix)

1,209 - 1,231

TMHMM
TMhelix (TMhelix)

1,123 - 1,145

TMHMM
TMhelix (TMhelix)

856 - 878

TMHMM
TMhelix (TMhelix)

1,097 - 1,116

TMHMM
TMhelix (TMhelix)

567 - 586

TMHMM
TMhelix (TMhelix)

1,180 - 1,202

TMHMM
TMhelix (TMhelix)

972 - 994

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,189 - 1,214

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

854 - 878

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

570 - 588

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

890 - 911

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

931 - 954

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,054 - 1,075

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,123 - 1,145

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,096 - 1,117

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,220 - 1,240

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

686 - 705

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

975 - 993

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd03684 (ClC_3_like)

772 - 1,258

CDD
cd03684 (ClC_3_like)
mobidb-lite (disord...)

154 - 173

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 149

MobiDB Lite
mobidb-lite (disorder_prediction)

1,449 - 1,474

MobiDB Lite
mobidb-lite (disorder_prediction)

450 - 476

MobiDB Lite
mobidb-lite (disorder_prediction)

201 - 257

MobiDB Lite
mobidb-lite (disorder_prediction)

289 - 325

MobiDB Lite
mobidb-lite (disorder_prediction)

1,512 - 1,547

MobiDB Lite
mobidb-lite (disorder_prediction)

1,483 - 1,502

MobiDB Lite
mobidb-lite (disorder_prediction)

715 - 766

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative Cl- selec...

779G

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

780S

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

781G

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

782V

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

783P

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

821G

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

822K

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

823E

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

824G

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

825P

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

1,122G

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

1,123I

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

1,124Y

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

1,125V

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

1,126P

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)

1,246Y

putative Cl- selectivity filter
779G, 780S, 781G, 782V, 783P, 821G, 822K, 823E, 824G, 825P, 1,122G, 1,123I, 1,124Y, 1,125V, 1,126P, 1,246Y
CDD
cd03684 (ClC_3_like)
putative pore gati...

823E

putative pore gating glutamate residue
823E
CDD
cd03684 (ClC_3_like)
putative H+/Cl- co...

880E

putative H+/Cl- coupling transport residue
880E
CDD
cd03684 (ClC_3_like)

Protein sequence

>MCA_05986_1
MKRSTPDFEPDSSSEVHDHHSTLSTPDPESRPSSNNNSQHSDNSESLSATPPQGYFVNQTTSIINPSPASYEAFNPLSSD
EDDEEDEFNDNESERTVEIKSTKPLNDSSQRESMISSSHAQELSLPFLRNSNNNNNNPENSNPSNSQNIVLENSSTSYSQ
SSDSTTPKANSIDNVEITDLSNIGPGLRQLTTKRKNLNLSTSTSFLSTMPRAENGNKLKDNDEAENEDNRTQRRQKSPTM
KRSRSATDTNRQKPKFPCSLLTRSAFSSFHLPSATSASSISAWPLPEHSRRKLSKMGHRRNKSESIKHSEDPETSRSSSV
SLKLELPPPSTFVDLRLPRLSPYFPAASTATTPGELSGKRVKSYFDFQNADESSRPMHPIFEHESRTNLHAPFVSTFKNV
GSHLNLAAGSSSQQAAARASSRESSLSRSSSLLNLSNEFGAYRRRKLARSTSRSGFFNERQSRKKSYTSLRSPVINSKPQ
LTSNHASYYGSLDGIGFTPLDQSQSSIPKTTTPDPNEEVATAIEQRRFYDDFTTTDWVRDTIHLSSRRKYLASLRGIRGR
LIRMWDASQGWILTSIVSFMFAFIVYCFDKAEEYLFELKNGVCTKNVLWGKQRCCLESTPTLLANDSLNSTNADIWKAHV
CSEYVSWEKLLTDENTFIGKIISRIFYGSQEGTEQGPAETRERVEFIAYLLFTVLFALIAATITLHSKTSTFVTTNSSQQ
QSSSSHSPDIAQKPDEDGQDYPHETTQLIPGSNTRHSSTTNASESVPSPQARVIYSAYGSGVPEVKTILSGFVIREYLGT
RALIYKASGLVFSLASGLCVGKEGPFVHLATCVGNIATRLFPKYSQNNLKRRQILAAASSAGVALAFGSPIGGVLFALEE
VTYYFLPHQLFRIFLCALMSAMFLVFIFNPYNRGTIVFFEVAYDKDAKWRAWELVCFVSLGIFGGIYGGLFCKFAGRWWP
DNFRKISFVKKYPRLEVLFVAIITGYLSFSNHFTRSAISELLLALTSPCKKPEASVYLTSFLVPMNPDTYTSSFSNQTIA
GGTFDSGSFSAVSLLNTTLVGAMGVGLGSTGKYMWAWSIENSSKLCPTSFDSLPSVIYQLLYALVVKIALTSVSFGMKVP
AGIYVPSMVIGALFGRIFGILVQYLGHAWSPQIVKIFHTFHLFQDTFSSGPIHGQETVKTIVNSVVPGAYAMAGAGAFMA
GVTRMSLTLVVILFELTGTLNYVMPFSVSILVANLVANMVEKQSLYEILIERNNFPFLDNRITLSFDSSLADICEQDSTK
KGPVIDISAGSYVTAGSLNKVLHELHMYGEIDGCIPIVKHETLFGVLPAPELEFALDKIKAHVSMEYFQQREEEEDAELA
QTQMVNDELVELFENVLCKISVKDTDIAKYHRYYYASDMAFNNNNNDDVEADEEEGIDRLITEEGISGDSEDSDEDEYGN
DSVIFEVDEILHDDDDDDNSDNERNERTRTRIRGMKINTFLKRRNNRSSNINNNSNSVATTPRHRRTFFLTPDASPGLGV
EHPTTTTTSEVPSLSLPSGPLPPGNDNNNNNVTVCDLTPYIDRAPIFLDIHSPMALVQMVFTKLGVRAIAVTRNENRGRH
GHGGGVFVCMVHKKQFVEYCHLRS

GO term prediction

Biological Process

GO:0006821 chloride transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity

Cellular Component

GO:0016020 membrane

Filter view on

Entry type

Status

Per-residue features