MIA_01233_1

Protein

Length

509 amino acids

Protein function

EGGNOG:	0PFT2		transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000180798	TNA1	Tna1p

Protein alignments

	%id	Aln length	E-value
MCA_05994_1	62.549%	510	0.0	MCA_05994_1
A0A1E3PD75_9ASCO	36.920%	474	8.65e-97	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_29178 PE=4 SV=1
UniRef50_G9MR46	35.551%	481	4.61e-93	Uncharacterized protein n=72 Tax=Fungi TaxID=4751 RepID=G9MR46_HYPVG
A0A0J9XA89_GEOCN	36.798%	481	7.12e-95	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA06s04619g PE=4 SV=1
Q6C9D4_YARLI	33.680%	481	5.45e-93	YALI0D12100p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D12100g PE=4 SV=1
A0A060SZZ6_BLAAD	35.766%	411	6.86e-80	ARAD1C12562p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C12562g PE=4 SV=1
A0A1E4TFX3_9ASCO	31.013%	474	4.70e-68	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2334 PE=4 SV=1
A0A167D5S6_9ASCO	26.115%	471	1.09e-47	Tna1p OS=Sugiyamaella lignohabitans GN=TNA1 PE=4 SV=1
TNA1_YEAST	26.243%	503	2.08e-46	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1
A0A1D8PNL8_CANAL	27.615%	478	2.01e-45	Tna1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TNA1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0012

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
28 - 471
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 509

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  47 - 434
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  272 - 471
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  28 - 243
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  42 - 470
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

224 - 285

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

347 - 357

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

102 - 107

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

472 - 509

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

158 - 168

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

407 - 417

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 32

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

29 - 239

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

282 - 485

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

441 - 451

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

55 - 76

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

128 - 132

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

189 - 199

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

309 - 327

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

379 - 383

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

137 - 156

TMHMM
TMhelix (TMhelix)

39 - 61

TMHMM
TMhelix (TMhelix)

418 - 440

TMHMM
TMhelix (TMhelix)

450 - 472

TMHMM
TMhelix (TMhelix)

76 - 98

TMHMM
TMhelix (TMhelix)

105 - 127

TMHMM
TMhelix (TMhelix)

328 - 347

TMHMM
TMhelix (TMhelix)

384 - 406

TMHMM
TMhelix (TMhelix)

352 - 374

TMHMM
TMhelix (TMhelix)

200 - 222

TMHMM
TMhelix (TMhelix)

168 - 190

TMHMM
TMhelix (TMhelix)

291 - 313

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

133 - 157

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

77 - 101

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

418 - 440

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

358 - 378

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

452 - 471

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

384 - 406

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

169 - 188

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

33 - 54

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

200 - 223

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

328 - 346

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

286 - 308

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

108 - 127

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

56Q

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

59I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

60F

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

61T

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

63E

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

64F

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

82I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

85C

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

86I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

89Y

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

93A

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

94V

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

96S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

97C

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

143E

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

144A

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

147L

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

148P

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

151S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

152F

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

155S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

167Q

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

168A

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

171T

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

172G

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

178N

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

302S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

305K

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

306Y

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

309N

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

310I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

313P

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

326I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

330S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

334F

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

337S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

341S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

393S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

396V

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

397Y

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

400I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

404V

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

405T

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

408S

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

420A

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

421L

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

424Q

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

425I

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

428G

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

429E

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

432G

putative substrate translocation pore
56Q, 59I, 60F, 61T, 63E, 64F, 82I, 85C, 86I, 89Y, 93A, 94V, 96S, 97C, 143E, 144A, 147L, 148P, 151S, 152F, 155S, 167Q, 168A, 171T, 172G, 178N, 302S, 305K, 306Y, 309N, 310I, 313P, 326I, 330S, 334F, 337S, 341S, 393S, 396V, 397Y, 400I, 404V, 405T, 408S, 420A, 421L, 424Q, 425I, 428G, 429E, 432G
CDD
cd06174 (MFS)

Protein sequence

>MIA_01233_1
MLETVQIYESEEYDTKPVDLGQYNIRWSQEKKLLLKIDLHLIPVCALFIFISLLDQGNIFTAEFDKMQSFIGLEGSQFNH
CIMICIVTYAVFAVPSCLGLIKTSPSSWLSTIVSCWGVVMTTMGIIHDFTGLFWSRFFLGVFEAGMLPGVSFVLSVWYKK
NELQVRQAVLTGLAVSANAFGGLLSWTISMMTGVGGLEGWRWVFIIEGSLSVVVGGFGFMIMCNYPDTSDLFSFSEKKIM
SKRVLAFEGWNMEEFDDEEDDDYEGEESEIMQLFKRYKWNGLEDSLIDWQVWLHTVIYIALSVAKYSINILLPRILSSMN
FTEEKIKLISIPVFTSSSISSILVAIASDKIAARSPALVLSFVMIIAGFIVVMISEVYDMRGSVAYSGVFLASIGVYTAI
PASVTWLSNNTMCQAKRLFALALQIGLGELGGVVATYIYINSNASKSFAHGLMIIIAFSGLILVILLSFIYSKINRKRIK
ICASTNAERLPNMDLALIGDKNVFFRYMN

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features