Protein

MIA_01153_1

Length
387 amino acids

Browser: contig01:3292136-3293421+

Protein function

EGGNOG:0PFNFHEM15Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
SGD closest match:S000005702HEM15Ferrochelatase, mitochondrial
CGD closest match:CAL0000185155HEM15Ferrochelatase

Protein alignments

%idAln lengthE-value
MCA_04642_177.337%3530.0MCA_04642_1
A0A0J9XGH5_GEOCN73.295%3520.0Ferrochelatase OS=Geotrichum candidum GN=BN980_GECA13s01506g PE=3 SV=1
A0A060TDL5_BLAAD63.788%3591.31e-173Ferrochelatase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D48664g PE=3 SV=1
A0A167F8A8_9ASCO64.327%3423.91e-169Ferrochelatase OS=Sugiyamaella lignohabitans GN=HEM15 PE=3 SV=1
UniRef50_A0A167F8A864.327%3421.07e-165Ferrochelatase n=3 Tax=Opisthokonta TaxID=33154 RepID=A0A167F8A8_9ASCO
Q59U72_CANAL61.389%3606.50e-162Ferrochelatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM15 PE=3 SV=1
A0A1E3PSP5_9ASCO65.732%3211.18e-157Ferrochelatase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81057 PE=3 SV=1
Q6C140_YARLI62.059%3401.79e-157Ferrochelatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F19470g PE=3 SV=1
HEMH_YEAST57.471%3481.04e-144Ferrochelatase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM15 PE=1 SV=1
A0A1E4TDF8_9ASCO55.102%3433.53e-129Ferrochelatase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144273 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9926
Predicted cleavage: 30

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 387

Detailed signature matches

  1. Family IPR001015
    Ferrochelatase
    1. MF_00323 (Ferrochel...)
    2. PF00762 (Ferrochela...)
    3. TIGR00109
  2. Domain IPR033659
    Ferrochelatase, N-terminal
    1. cd03411 (Ferrochela...)
  3. Domain IPR033644
    Ferrochelatase, C-terminal
    1. cd00419 (Ferrochela...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SSF53800 (Chelatase)

Residue annotation

  1. C-terminal domain ...
  2. active site cd03411
  3. active site cd00419
  4. N-terminal domain ...

Protein sequence

>MIA_01153_1
MILGRALSATKVARSSGFKSTRCFWNVRNNSTLTEKDSKGTAIVLLNMGGPSTIPEVRDFLFRLFSDKDIIPLGPFQNIL
AKFITARRTPTIESHYKEIGGGSPIRKWSEYQAAEACKILDKISPATAPHKPYVAFRYANPLTEETYQKILDDGITRAVA
FSQYPQYSISTTKSSFNELERIRKIVDPEKKVKWTGIQRWPTHPKLVKAFAKNISAQLENFPAADRDKVVIVFSAHSIPI
DFVNSADTYPPEVASTVHAVMQELKFCNPYRLAWQSQVGPKPWLGPKTNRTIATLESNPDIKGIVIVPIAFTSDHIETLH
ELDIELIEECKRPEIVRRAESLNGSPLFIEALADIVACHLDPATHDPDGSKQVQSGVAIKTFDLKVK

GO term prediction

Biological Process

GO:0006783 heme biosynthetic process

Molecular Function

GO:0004325 ferrochelatase activity

Cellular Component

None predicted.