Protein

MCA_04642_1

Length
399 amino acids

Gene name: HEM15

Description: Ferrochelatase, mitochondrial

Browser: contigC:3582176-3583376+

RNA-seq: read pairs 8260, FPKM 255.2, percentile rank 90.6% (100% = highest expression)

Protein function

Annotation:HEM15Ferrochelatase, mitochondrial
KEGG:K01772hemH protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1 4.99.1.9]
EGGNOG:0PFNFHEM15Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
SGD closest match:S000005702HEM15Ferrochelatase, mitochondrial
CGD closest match:CAL0000185155HEM15Ferrochelatase

Protein alignments

%idAln lengthE-value
MIA_01153_177.34%3530.0MIA_01153_1
A0A0J9XGH5_GEOCN68.84%3531e-178Ferrochelatase OS=Geotrichum candidum GN=BN980_GECA13s01506g PE=3 SV=1
A0A060TDL5_BLAAD64.29%3507e-165Ferrochelatase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D48664g PE=3 SV=1
A0A167F8A8_9ASCO63.05%3418e-155Ferrochelatase OS=Sugiyamaella lignohabitans GN=HEM15 PE=3 SV=1
UniRef50_A0A167F8A863.05%3412e-151Ferrochelatase n=3 Tax=Opisthokonta TaxID=33154 RepID=A0A167F8A8_9ASCO
Q59U72_CANAL60.45%3541e-150Ferrochelatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM15 PE=3 SV=1
Q6C140_YARLI61.25%3516e-150Ferrochelatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F19470g PE=3 SV=1
A0A1E3PSP5_9ASCO63.50%3261e-148Ferrochelatase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81057 PE=3 SV=1
HEMH_YEAST55.99%3342e-132Ferrochelatase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM15 PE=1 SV=1
A0A1E4TDF8_9ASCO56.63%3324e-126Ferrochelatase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144273 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7853
Predicted cleavage: 47

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 399

Detailed signature matches

  1. Family IPR001015
    Ferrochelatase
    1. MF_00323 (Ferrochel...)
    2. PF00762 (Ferrochela...)
    3. TIGR00109
  2. Domain IPR033659
    Ferrochelatase, N-terminal
    1. cd03411 (Ferrochela...)
  3. Domain IPR033644
    Ferrochelatase, C-terminal
    1. cd00419 (Ferrochela...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. SSF53800 (Chelatase)

Residue annotation

  1. C-terminal domain ...
  2. active site cd03411
  3. active site cd00419
  4. N-terminal domain ...

Protein sequence

>MCA_04642_1
MFRQYISSNSCVLRSFTRQFHSTYIKFQESSSSTVTKSSIHHEKRPGTAIVLLNMGGPSTIPEVRDFLFRLFSDKDIIPL
GPFQDLVAKFITTRRTPKIEEHYEEIGGGSPIRKWSEYQASEACKLLDKISPSTGPHSPYVAFRYANPLTEETYLKMMNA
GITRAVAFSQYPQYSRATSKSSFKELERIQKIVDPSKTIEWTYIQRWPTHPKLVKAFAQNIEKALSQFDEEQRKEVVILF
SAHSIPMDFVNSADTYPAEVAATVHAVMKELKFSNPYRLTWQSQVGPKSWLGPKTNKTVGTLVDFKKKTGKPRPVVMVPI
AFTSDHIETLHELDIELVEECGGDKNLIRRAESLNGSPLFIEALADIVACHLDPKTHDPTGEKQVESGVLIKQLELDVK

GO term prediction

Biological Process

GO:0006783 heme biosynthetic process

Molecular Function

GO:0004325 ferrochelatase activity

Cellular Component

None predicted.