Protein

MIA_01149_1

Length
1,263 amino acids

Browser: contig01:3280618-3284465-

Protein function

EGGNOG:0PFIEDOA4ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000002476DOA4Ubiquitin carboxyl-terminal hydrolase 4
CGD closest match:CAL0000183207DOA4Ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
MCA_02307_153.676%8160.0MCA_02307_1
UniRef50_A0A1E3PY8038.931%7861.06e-137Uncharacterized protein n=1 Tax=Lipomyces starkeyi NRRL Y-11557 TaxID=675824 RepID=A0A1E3PY80_LIPST
A0A060SZI5_BLAAD54.881%3791.42e-120ARAD1C05126p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05126g PE=3 SV=1
A0A167F4G6_9ASCO55.526%3718.06e-117Doa4p OS=Sugiyamaella lignohabitans GN=DOA4 PE=3 SV=1
A0A1E3PS26_9ASCO54.645%3665.76e-117YDR069Cp-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20338 PE=3 SV=1
Q6C1K8_YARLI52.342%3632.05e-99YALI0F15367p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F15367g PE=3 SV=1
A0A0J9XI17_GEOCN50.400%3752.33e-96Similar to Saccharomyces cerevisiae YDR069C DOA4 Ubiquitin isopeptidase OS=Geotrichum candidum GN=BN980_GECA18s00527g PE=3 SV=1
A0A1E4TAT8_9ASCO47.107%3636.53e-93Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32326 PE=3 SV=1
UBP4_YEAST48.525%3737.31e-90Ubiquitin carboxyl-terminal hydrolase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DOA4 PE=1 SV=2
A0A1D8PFU3_CANAL43.880%4332.84e-88Ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DOA4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0405
Predicted cleavage: 24

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1263

Detailed signature matches

  1. Domain IPR001763
    Rhodanese-like domain
    1. SSF52821 (Rhodanese...)
    2. SM00450 (rhod_4)
    3. G3DSA:3.40.25...
  2. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  3. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  4. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.90.70.10
  2. SSF54001 (Cysteine ...)
  3. cd02674 (Peptidase_...)
  4. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02674

Protein sequence

>MIA_01149_1
MSFQSSEQIFSSSPLPFTSNIRQTSDKVDDSDYLGTLREFAVNSLYQYSEINDCFETAKYLFESVSDICIIVSEHILIIM
KYREIVNSNGDLEKAYIDYYKSYFSVIHTIRSHSSFEKKKADSNFASQFYALEKQIFESEGDVKLLENKIIERRNMKLEQ
KHMNHFLDTSTSPETAFSQLTPPNLHFHLETSHDEMNSSNHSLALPPSSFSELPTVSSLSSSNIFPSHSSSSLHSLPQPK
SPAPMPPLDNTIHLHPQTVPQPSIPAPEPPKINSTAIPIVHSQSRSPSPDKLDPRNFKIHRKNVETNEIAILDSINTENR
KSLDSSNDFATSLEQRFSRLRTNSNNNYSNSQVRKGLLDTNLASNNLHNQSPTIVPPKKEKTRYYRPLPMPDVPPDFHDS
PKGQGSKNYILSMPEPNIAPEEPLNNKAFNRNNETNNVLPIPKSNGNSNFSSAVLIPKSNGSHPPSGVAISFSPPGSQSP
THNLVYAPHNREFNFPKTFVILPEELHKLLQLYPEQILIIDIRPREYFNNGHIPSSNVVCFEPVAIHSSLVVNDSTLEQA
LVLSPDHEQLLFKQRHKFPFVVYYDANTRSADFLNGRYLNEQDKRLATFIDYLYRKPINKALRRPPALLIGGLEGWTKIY
GKDKIWKSATLPLDLPPSASASLNSIRSTGDSEIHHPNTTMPSFNQQHPAPLWKEKYSENNAIVAPKIPQVIPSRPYGSR
KGSTASPNHRLSFDGSIPPVTTTAHDITVGTSSYNYARNTNDFFTMPTPTVPQSLQTTYSSSRPTTTQDLYSIPLKNGRH
NRPMPFSDGTQRSDSNLPKLPPPVAHVPQSQSQYPHMEINSGYAMGHAPGISDSHSGGLMLGQLPPIQNMCTNGPGSSPM
VQPSQNGQMMKKQPDALNQILRSFSTGLSNLGNTCYMNCIIQCVAATEKLARPIITMPDLANLNSKLGYKGVLYSTFSRL
LQEMIRKDNSYVSPLEFRKLCGSLSQTFSGYQQQDCQEFLNFLLDGLHEELNRAGDKKPLKPLTEDEERVQEQLSFRVAS
AKQWKRYLYSNNSPISTLIQGQYLSRLTCTVCQTTSTTYNAFSCLSLPIPSGSNIGRNGVRLVDCFRLFTMEEVLDGDNA
WHCPQCKKRRKTTKTMKITRLPEILIIHLKRFKQHGTTSNKLETFVSYPITSLDLTEFWVQPTTQADETVQHGGQYPPFL
YNLYGVATHQGTLKGGHYTSFVKRGQNGWCYFDDTRVYRNVNPSHVVTQHAYVLFFERVRPVH

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.