Protein
MCA_02307_1
Length
1,142 amino acids
Gene name: DOA4
Description: Ubiquitin carboxyl-terminal hydrolase 4
Browser: contigB:895368-898960-
RNA-seq: read pairs 1730, FPKM 18.7, percentile rank 39.7% (100% = highest expression)
Protein function
| Annotation: | DOA4 | Ubiquitin carboxyl-terminal hydrolase 4 | |
|---|---|---|---|
| KEGG: | K11839 | USP8 | ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12] |
| EGGNOG: | 0PFIE | DOA4 | ubiquitin carboxyl-terminal hydrolase |
| SGD closest match: | S000002476 | DOA4 | Ubiquitin carboxyl-terminal hydrolase 4 |
| CGD closest match: | CAL0000183207 | DOA4 | Ubiquitin-specific protease |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01149_1 | 53.33% | 812 | 0.0 | MIA_01149_1 |
| A0A060SZI5_BLAAD | 54.75% | 358 | 1e-120 | ARAD1C05126p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05126g PE=3 SV=1 |
| UniRef50_A0A060SZI5 | 54.75% | 358 | 3e-117 | ARAD1C05126p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060SZI5_BLAAD |
| A0A167F4G6_9ASCO | 53.51% | 370 | 6e-116 | Doa4p OS=Sugiyamaella lignohabitans GN=DOA4 PE=3 SV=1 |
| A0A1E3PS26_9ASCO | 51.10% | 364 | 6e-114 | YDR069Cp-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20338 PE=3 SV=1 |
| A0A0J9XI17_GEOCN | 48.94% | 376 | 9e-104 | Similar to Saccharomyces cerevisiae YDR069C DOA4 Ubiquitin isopeptidase OS=Geotrichum candidum GN=BN980_GECA18s00527g PE=3 SV=1 |
| Q6C1K8_YARLI | 51.52% | 363 | 8e-102 | YALI0F15367p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F15367g PE=3 SV=1 |
| A0A1E4TAT8_9ASCO | 47.25% | 364 | 4e-96 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32326 PE=3 SV=1 |
| UBP4_YEAST | 45.70% | 372 | 2e-94 | Ubiquitin carboxyl-terminal hydrolase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DOA4 PE=1 SV=2 |
| A0A1D8PFU3_CANAL | 43.54% | 418 | 7e-93 | Ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DOA4 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3193
Predicted cleavage: 29
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1142
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
SSF54001 (Cysteine ...)
-
cd02674 (Peptidase_...)
-
mobidb-lite (disord...)
Residue annotation
-
Active Site cd02674
Protein sequence
>MCA_02307_1 MSNYNTQAPATQIQPNVALNTQQNGKRPTANGVDSNSRQSNFKSSESDYLKTLRELASNSCETKGTIYDCLNTALDSFLE YDKAMKSGGDLEKAYISYYKAHFCMIHTIPSHPKFAQKHGTKKFQEVYDPLNQSILHDREKVKILEQKIINERNRSMINK QRLVNTPNSKSISQKSAVESQTSLPLSQNTNTNPPASPKKKPTYNIPRKQPTNSKNSHLTDSSTSIDNDFANLNLSNGGD TYQSQTQGQTDNLSSPHRPDSVNVSSLRTNQLQYEFPKRPMSEVNLSKSNLTYSFSSLNQNPQNNYIPSQSASNDFEYSS APQPPVHRVPLKTSRENHDSRFSGFKHTIEQSELRELLQECPENVLLIDIRFRNEFNNGHLPSSNVVCFEPVGIRSTEFM SDDKLEDALVIAPDHEQHLFEKRNTFPLVVYYDNDTSNADFLTGSFGSDHDKKLSLFVDYIYHRATTKKLRQHPCLLVGG IEGWIDRYGKESTWKSADLPLELPSSTNFTARLRMPELPVMPSINGTSQNYDRNSTLGYDYNNNTIHENIRTDSFDNDPA SGSSIRVVDSSQNTFWNSKYITDKTQIFAPQPPKEIPSRPYGSRKGSVASTNKRLSFDGSAAYNPVPDYLNNNDPTVNNI NSYPYARSPTDLMTMPAKQMVPQSLQTPYDPNARSHRNGEMYTFSNRQSNGHYNTNNNPRNTHNTTHGLPQLPPPVAHVP QSQSQYPHSEINSGYAMGQAVNYNNNNRNMPSPYSGLLNPNGVPMSNAIRTTTKSGFQLELMRSFTTGLRNLGNTCYMNC IIQCLAATEKFAPMFMNGLYMVNLKSKMGYKGALASSFAHLLQEMVRKNRSFVSPDHFRALCGSLSETFRGYEQQDCHEF LNFLLDGLHEELNAAGNKTPLKPLTEEQERMQERLSLRVASANEWSRYSYSNNSPVTSRIQGQYLSRLQCTVCNFTSTTF NAFSCLSLPIPQHRNPVDLKECFQLFTQQEILDGDNAWNCPNCKTRRRTIKTMRISRLPYTLIVHLKRFRQTSRGTSDKL EVMVTYPLQGLDLTEFWVRPTGPEDNKAQQGGQHPPFIYNLFAVATHTGSLKGGHYTSFVKKSGPNGWCYFDDYKYYTQV KPAHVQTENAYVLFFERIPPVQ
GO term prediction
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
Molecular Function
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
Cellular Component
None predicted.