Protein

MIA_01132_1

Length
302 amino acids

Browser: contig01:3243188-3244097-

Protein function

EGGNOG:0PN04PUS5responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery
SGD closest match:S000004155PUS521S rRNA pseudouridine(2819) synthase

Protein alignments

%idAln lengthE-value
MCA_02323_143.000%3006.58e-77MCA_02323_1
A0A0J9X4J2_GEOCN33.636%3304.12e-43Similar to Saccharomyces cerevisiae YLR165C PUS5 Pseudouridine synthase OS=Geotrichum candidum GN=BN980_GECA02s05543g PE=4 SV=1
UniRef50_A0A0J9X4J233.636%3308.44e-40Similar to Saccharomyces cerevisiae YLR165C PUS5 Pseudouridine synthase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X4J2_GEOCN
A0A1E3PHZ0_9ASCO37.551%2453.25e-36Pseudouridine synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51577 PE=4 SV=1
PUS5_YEAST27.570%2141.44e-1721S rRNA pseudouridine(2819) synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUS5 PE=1 SV=1
Q6CG33_YARLI26.633%1998.27e-08YALI0B01276p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B01276g PE=4 SV=1
A0A167CCR8_9ASCO31.387%1376.21e-07Bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2 OS=Sugiyamaella lignohabitans GN=RIB2 PE=4 SV=1
A0A1E4TM99_9ASCO29.787%1413.78e-06Pseudouridine synthase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22508 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4059

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 302

Detailed signature matches

  1. Domain IPR020103
    Pseudouridine synthase, catalytic domain
    1. SSF55120 (Pseudouri...)
  2. Domain IPR006145
    Pseudouridine synthase, RsuA/RluB/C/D/E/F
    1. PF00849 (PseudoU_sy...)
  3. SITE IPR006224
    Pseudouridine synthase, RluC/RluD, conserved site
    1. PS01129 (PSI_RLU)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.23...
  2. cd02869 (PseudoU_sy...)

Residue annotation

  1. active site cd02869

Protein sequence

>MIA_01132_1
MPPRISVLKQLPHYLVINKPPSCYSQPPDTSPANKQLELHGISPDDTVLAHLRHDNPALFDQSKLKPPFCPPKLVHRLDY
PVSGAMVLATSTQSAAHFAKNLKFGGAKGWVLQKYYAALVLGSPKTSSSFLQKTITWTPDIVTNEGPVKTGIIAKHIDGK
QAFTRFWIPPQPTAPRLPYSLVLFSPLTGRKHQIRKHAAEVLQTPILGDSTYIDQIDRRKSKLDSITKNTSLTPLADLSA
LYPVNGIALHSYMVHLETGLAKSSIQAPFFRNTEAWDPFLTKDRLLPDTLYSSCVAEKVKLM

GO term prediction

Biological Process

GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification

Molecular Function

GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity

Cellular Component

None predicted.