Protein

MIA_01111_1

Length
1,330 amino acids

Browser: contig01:3179021-3183084-

Protein function

EGGNOG:0PGKJMDR1Multidrug resistance protein
SGD closest match:S000004178MDL1ATP-dependent permease MDL1, mitochondrial
CGD closest match:CAL0000191535MDL1ATP-binding cassette permease

Protein alignments

%idAln lengthE-value
MCA_03349_167.127%13020.0MCA_03349_1
A0A0J9XFY3_GEOCN60.502%12760.0Similar to Saccharomyces cerevisiae YKL209C STE6 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor OS=Geotrichum candidum GN=BN980_GECA12s02551g PE=4 SV=1
A0A161HLQ6_9ASCO58.909%13020.0ATP-binding cassette alpha-factor transporter STE6 OS=Sugiyamaella lignohabitans GN=STE6 PE=4 SV=1
UniRef50_A0A161HLQ658.909%13020.0ATP-binding cassette alpha-factor transporter STE6 n=13 Tax=Saccharomycetales TaxID=4892 RepID=A0A161HLQ6_9ASCO
A0A1E3PRN7_9ASCO56.610%12860.0p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48738 PE=4 SV=1
A0A060SYY2_BLAAD57.311%12720.0ARAD1A15114p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A15114g PE=4 SV=1
Q6CH81_YARLI52.987%12720.0YALI0A11473p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A11473g PE=4 SV=1
A0A1E4THX0_9ASCO47.928%12790.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32011 PE=4 SV=1
Q5A951_CANAL33.581%5395.19e-70ATP-binding cassette permease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDL1 PE=4 SV=1
MDL1_YEAST33.531%5078.15e-70ATP-dependent permease MDL1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDL1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0060

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1330

Detailed signature matches

  1. Domain IPR011527
    ABC transporter type 1, transmembrane domain
    1. PS50929 (ABC_TM1F)
    2. PF00664 (ABC_membrane)
    3. SSF90123 (ABC trans...)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR003439
    ABC transporter-like
    1. PF00005 (ABC_tran)
    2. PS50893 (ABC_TRANSP...)
  4. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  5. SITE IPR017871
    ABC transporter, conserved site
    1. PS00211 (ABC_TRANSP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:1.20.15...
  3. G3DSA:3.40.50...
  4. NON_CYTOPLASM... (N...)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. cd03249 (ABC_MTABC3...)
  8. mobidb-lite (disord...)

Residue annotation

  1. Walker A/P-loop cd...
  2. ATP binding site c...
  3. Q-loop/lid cd03249
  4. ABC transporter si...
  5. Walker B cd03249
  6. D-loop cd03249
  7. H-loop/switch regi...
  8. Walker A/P-loop cd...
  9. ATP binding site c...
  10. Q-loop/lid cd03249
  11. ABC transporter si...
  12. Walker B cd03249
  13. D-loop cd03249
  14. H-loop/switch regi...

Protein sequence

>MIA_01111_1
MNEPTHSLDPQPSYLQEKNIKTHHIHITKSHSEKPEKPQSKEQSKDDDSNDYIKSLNFEGRTDKEIEILKSQITQPSQTL
SYFTLYRYATRFDLFLIFCSNLSAVISGAALPLFTLVMGGITNDFTRFLTTGQGGDEFQKSVNHNTLFFLYLMIGILFFS
VFQTFISVERGEVLTARIREHYIKAILRQNIAYFDKIGPGEITNRITSDINVIQEGISEKVNLVFQGFSTFFSAIVISFV
RSWRLSLILLSTMFAIIFTMGACSFFIMKYTISGLDAFSKASSVAEDILSSIRTTTAFGIQSRLTKEYLRNVDVSFASGV
KAGRAIMVMSGVLWAIAYWNYGLAFWQGARFIANGSTSPGAMITVTISIMIGALSIGNVAPAFQSIGKSVGAAQKIFEAI
DRVPVIDSSSDEGAKLDSVTGKIEFRNVCFAYPSRPNVTVLEDFSLSINPGETVALVGASGSGKSTVIGILERFYSYLGG
SVTLDGVELSTFNVKWLRQNISLVSQEPTLFSVSIYENICYGLIGTDHENAPDEEKLKLVEDACKQANAWDFIQTLPQKL
DTNVGQQGFLLSGGQKQRIAIARAIVSQPKILLLDEATSALDTKSEGVVQEALDRVSANRTTIVIAHRLSTIKDADKIVV
LSSGAIIETGTHSELLEKKGAYYSLVKAQGIKHNDSHHHRSSNHSIKSSDERSIGSEKTDNLGLTLSKTVSSTQSISEKV
IADLTENGYFDTQHVKRTVFQLVKFLLQFTKGHNKIIVFGIVGGIIAGVGYPIMAFLFGKILNSVMVTPDQYPQMRHDVN
VYAGYCVLLGGIELIVTFILYGTMTYHTQVLVKSIRVKVFEHYLKMDIAFFDEDENSTGALTSTLSKDGQNVEGFGGVTL
SQILNSLVILISGVIIAIIINWRLGLVCTACVPLLVGCGFLRVFILLRLEERAKKTYEESGQYACESVSAVRTVASLTKE
EHVCQIYSQTVESQLSKSRPAILRSAILFGVSDGFSPGIMGLGFWYGATLIRKGQSSPYMFFTAFVAVVFGAQSAGNIFS
YSSSIGKAQQASQNIASILDVKPHIDPTSTEGEVLENTVGNIEFRNVHFRYPTRLHVPVLRGLDITVKHGQYVALVGSSG
CGKSTTVSLLERFYHPLSGQILLDGVDITTLNIKKYREHIGLVQQEPVLFNGTIRENILLGLDEDQAAVLPEEELYNAAK
KANIHDFIMSLPQGYETETGMKGTLLSGGQKQRIAIARAMIRNPKVLLLDEATSALDSESEKVVQAALDEAAKGRTTIAV
AHRLSTIQNADMIYLIDKGRVAESGTHSELIEMEGLYYQLVKMQDLNKSR

GO term prediction

Biological Process

GO:0006810 transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0016021 integral component of membrane