Protein
MCA_03349_1
Length
1,355 amino acids
Gene name: STE6A
Description: Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor
Browser: contigB:4118291-4122359-
RNA-seq: read pairs 10441, FPKM 95.1, percentile rank 77.8% (100% = highest expression)
Protein function
| Annotation: | STE6A | Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor | |
|---|---|---|---|
| KEGG: | K05658 | ABCB1 | ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:3.6.3.44] |
| EGGNOG: | 0PGKJ | MDR1 | Multidrug resistance protein |
| SGD closest match: | S000001692 | STE6 | Alpha-factor-transporting ATPase |
| CGD closest match: | CAL0000191535 | MDL1 | ATP-binding cassette permease |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01592_1 | 72.49% | 1287 | 0.0 | MIA_01592_1 |
| A0A0J9XFY3_GEOCN | 63.55% | 1295 | 0.0 | Similar to Saccharomyces cerevisiae YKL209C STE6 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor OS=Geotrichum candidum GN=BN980_GECA12s02551g PE=4 SV=1 |
| A0A161HLQ6_9ASCO | 58.44% | 1309 | 0.0 | ATP-binding cassette alpha-factor transporter STE6 OS=Sugiyamaella lignohabitans GN=STE6 PE=4 SV=1 |
| UniRef50_A0A161HLQ6 | 58.44% | 1309 | 0.0 | ATP-binding cassette alpha-factor transporter STE6 n=13 Tax=Saccharomycetales TaxID=4892 RepID=A0A161HLQ6_9ASCO |
| A0A1E3PRN7_9ASCO | 58.13% | 1285 | 0.0 | p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48738 PE=4 SV=1 |
| A0A060SYY2_BLAAD | 58.98% | 1280 | 0.0 | ARAD1A15114p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A15114g PE=4 SV=1 |
| Q6CEX3_YARLI | 54.51% | 1286 | 0.0 | YALI0B12188p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12188g PE=4 SV=1 |
| A0A1E4THX0_9ASCO | 49.11% | 1297 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32011 PE=4 SV=1 |
| STE6_YEAST | 27.12% | 1213 | 7e-110 | Alpha-factor-transporting ATPase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE6 PE=1 SV=1 |
| Q5A951_CANAL | 33.46% | 511 | 4e-75 | ATP-binding cassette permease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDL1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0257
Protein family membership
None predicted.
Domains and repeats
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Domain
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Domain
1
200
400
600
800
1000
1200
1355
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
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NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
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cd03249 (ABC_MTABC3...)
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mobidb-lite (disord...)
Residue annotation
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Walker A/P-loop cd...
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ATP binding site c...
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Q-loop/lid cd03249
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ABC transporter si...
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Walker B cd03249
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D-loop cd03249
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H-loop/switch regi...
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Walker A/P-loop cd...
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ATP binding site c...
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Q-loop/lid cd03249
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ABC transporter si...
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Walker B cd03249
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D-loop cd03249
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H-loop/switch regi...
Protein sequence
>MCA_03349_1 MDEKLSNNSSSMSPEDSSTQGKPVDIENVNTVPTHDDEKHNKKGFFHKSKKSKQDEKDPKGDPTQESELSYEGRTSSEIA ILKDQIVIPEHKVTYFTIFRYATKFDLFLIFLSHFLSICAGAALPLFTIIMGNLTNDFNTFLTTGQGAEAFQDSVNHNTL YFVYLGVGIGVATAIETFLAVDRGEVITARIREQYIRGILRQNIGYFDKIGPGEITNRISSDITLIQEGISEKVNLVYTG FATFFAGLVIGFIKSWRITLILFSTIVAIILVMGGLSSFMMKYILASLSSFGKAATVAEDILSAIRTTTAFGIQSRLSQR YISFVNESFRNGVISGRFLMCMVAGIWTIVYLTYGLAFWQGARFIADGTDNPGNLITVIMCVIIGSISIGAVVPAFQSMG KAVGAAKKVFEAIDRHPVIDSLSDEGDTIPEVSGNIELKNVKFAYPSRPNVTVLENFSLSIKPGQTVALVGSSGSGKSTI IGLIERFYDYLEGSITLDGHELRDLNVRWLRQQLALVSQEPTLFSVSIFENIAFGLIGTPYEHASDEEKMPLIVKACKEA NAWDFIQNLPDGLETNVGQQGFLLSGGQKQRIAIARAIVSEPKILLLDEATSALDTKSEGVVQEALDRASAQRTTIVIAH RLSTIKDADNIVVMSSGQIIEQGTHHELLERKGAYYKLVHAQNIRGENEPKKHHEKHESAPETQTTYDDNAVKPITRSLS SSSAGSDVMLAKRKTNASIQSASEQKIKDLEAAGMLNSDVKTRSTITLVKYLLQFTKGYNWMLFIGIAAALGSGAGYPIM AFLYGKILNALMVPPDQYPQMRHDVNVLSGYFVLLAGLEFFIFATLLGVFTWHTQKLVSQIRIKVFEHYLRMDIAFFDDE NHSTGALTSTLSKDGQGVEGFGGVTLGQILNSLSVLIGGIIMAIVVNWRLGLVCTACVPLLVGCGFLRVYVLVKLEERSK KVYAKSAEFACESVSAIRTVASLSKENLVWSTYKRSVEDQVRASRIPAGRSGIMYGLAQALLPLIMGLGFWYGATLIKDG KITSYQFFTALVAIVFGAQSAGQVFSYAPSMGKAKQASQNIARIFDIEPTIDPTSTEGDVMTNVVGDIEFRDVHFRYPTR LHVPVLRGLNLTVKRGQYVALVGSSGCGKSTTIGLIERFYEPLAGQVLLDGVDVTTLNVAKYRSHIGLVQQEPVLFYGTI RENILYGLDDDQIQNVTEEDIINAAKKANIHNFIMTLPEGYETNTGSKGTLLSGGQKQRIAIARALIRNPKVLLLDEATS ALDSESEKVVQAAIDEAAKGRTTIAVAHRLSTIQNADVIYVFDGGKVVESGTHDELLKLDGLYSQLVKMQDLESK
GO term prediction
Biological Process
GO:0006810 transport
GO:0055085 transmembrane transport
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Cellular Component
GO:0016021 integral component of membrane